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    BIOPOLYMER OPTICAL ANALYSIS DEVICE AND METHOD
    1.
    发明公开
    BIOPOLYMER OPTICAL ANALYSIS DEVICE AND METHOD 审中-公开
    生物聚合物光学分析装置和方法

    公开(公告)号：EP2623960A1

    公开(公告)日：2013-08-07

    申请号：EP11828589.9

    申请日：2011-07-21

    申请人： Hitachi High-Technologies Corporation

    发明人： OZAWA Satoshi ,  ANAZAWA, Takashi ,  AKAHORI, Rena ,  TAKAHASHI, Satoshi ,  OHURA, Takeshi ,  KIGUCHI, Masashi

    IPC分类号： G01N21/65 ,  B82Y5/00 ,  B82Y15/00 ,  C12N15/09 ,  G01N37/00

    摘要： The present invention provides a device and method for analyzing the characteristics of a biopolymer with excellent mechanical stability, high spatial resolution and sensitivity using a simple device construction. Specifically, the Raman scattered light of a biopolymer is measured and the properties of monomer units forming the biopolymer are analyzed by using a biopolymer property analysis chip (100a) characterized by comprising: a solid substrate (110); at least one nanopore (120) disposed in the solid substrate (110); and one or more electrically conductive thin films (130a, 1 30b) disposed on the solid substrate (110). The biopolymer property analysis chip (100a) is characterized in that the electrically conductive thin films (130a,130b) are disposed partially on the solid substrate (110) where the nanopore (120) is formed and a biopolymer which has penetrated into the nanopore (120) is caused to generate Raman scattered light by means of irradiation with external light.

    摘要翻译： 本发明提供了使用简单的装置构造来分析具有优异的机械稳定性，高空间分辨率和灵敏度的生物聚合物的特性的装置和方法。 具体而言，测量生物聚合物的拉曼散射光，并且通过使用生物聚合物性质分析芯片（100a）分析形成生物聚合物的单体单元的性质，所述生物聚合物性质分析芯片（100a）包括：固体基底（110）; 布置在所述固体基底（110）中的至少一个纳米孔（120）; 和设置在固体基底（110）上的一个或多个导电薄膜（130a，130b）。 生物聚合物特性分析芯片（100a）的特征在于，导电薄膜（130a，130b）部分地设置在形成有纳米孔（120）的固体基板（110）上，并且已经渗透到纳米孔中的生物聚合物 120）通过外部光的照射而产生拉曼散射光。

    BIOPOLYMER ANALYSIS METHOD, BIOPOLYMER ANALYZER, AND BIOPOLYMER ANALYSIS CHIP
    4.
    发明公开
    BIOPOLYMER ANALYSIS METHOD, BIOPOLYMER ANALYZER, AND BIOPOLYMER ANALYSIS CHIP 有权
    生物多样性分析仪

    公开(公告)号：EP2557158A1

    公开(公告)日：2013-02-13

    申请号：EP11762135.9

    申请日：2011-02-23

    申请人： Hitachi High-Technologies Corporation

    发明人： AKAHORI, Rena ,  ANAZAWA, Takashi ,  OZAWA, Satoshi ,  YAZAWA, Yoshiaki ,  SAKAI, Tomoyuki ,  NODA, Hideyuki

    IPC分类号： C12N15/09 ,  C12M1/00 ,  C12Q1/68 ,  G01N21/64 ,  G01N27/00 ,  G01N27/22 ,  G01N33/53 ,  G01N37/00 ,  G01N27/416

    CPC分类号： C12Q1/6869 ,  G01N21/6428 ,  G01N33/48721 ,  C12Q2565/631

    摘要： There have been the following problems with sequence analysis using multiple nanopores: trapping a sample in the nanopores is not always 100% efficient and unnecessary time is spent to measure pores in which no sample has been trapped, resulting in low measurement efficiency. To address the problems, a labeling substance is boned to a sample, and the sample to which the labeling substance has been bonded is trapped in the nanopores. An apparatus for observing the labeling substance is used to observe the labeling substance and monitor whether or not the sample has been trapped in the nanopores. Measuring only nanopores in which the sample has been trapped allows the measurement efficiency to be improved.

    摘要翻译： 使用多个纳米孔的序列分析存在以下问题：在纳米孔中捕获样品并不总是100％的有效性，并且花费不需要的时间来测量没有样品被捕获的孔隙，导致低的测量效率。 为了解决这些问题，将标记物质结合到样品中，并且标记物质已经结合的样品被捕获在纳米孔中。 用于观察标记物质的装置用于观察标记物质并监测样品是否已被捕获在纳米孔中。 仅测量样品已被捕获的纳米孔，可以提高测量效率。