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1.发明授权A 6-fluoro-1,4-dihydro-4-oxo-7-substituted piperazinyl-quinoline-3-carboxylic acid derivative and the method for preparing the same 失效6-氟-1,4-二氢-4-氧代-7-取代的哌嗪基 - 喹啉-3-羧酸衍生物及其制备方法
公开(公告)号：EP0140116B1
公开(公告)日：1988-05-25
申请号：EP84111035.6
申请日：1984-09-15
发明人： Itoh, Yasuo , Kato, Hideo , Ogawa, Nobuo , Koshinaka, Eiichi , Suzuki, Tomio , Yagi, Noriyuki
IPC分类号： C07D401/04 , A61K31/47
CPC分类号： C07D215/56
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2.发明公开Xanthine compound, method for preparing thereof, and a pharmaceutical composition comprising the same 失效XANTHINE化合物，其制备方法和包含其的药物组合物
公开(公告)号：EP0430025A3
公开(公告)日：1992-05-06
申请号：EP90122146.5
申请日：1990-11-20
IPC分类号： C07D473/06 , A61K31/52
CPC分类号： C07D473/04
摘要： A novel xanthine compound having bronchodilating and brain function improving activity represented by the following formula (I) and (II):
wherein R¹ represents a hydrogen atom, 4-methoxybenzyl group, a straight- or branched-chain alkyl group having 1 to 6 carbon atoms, or a cycloalkyl group having 3 to 6 carbon atoms; R² represents a hydrogen atom, a straight- or branched-chain alkyl group having 1 to 6 carbon atoms, or a cycloalkyl group having 3 to 6 carbon atoms; n represents an integer of from 1 to 4; and A represents -COCH₃ or - C(OR³)(OR⁴)CH₃ in which R³ and R⁴ independently represents an alkyl group having 1 to 3 carbon atoms or R³ together with R⁴ represents a polymethylene group having 2 to 4 carbon atoms is disclosed. Also disclosed are a pharmacologically acceptable salt of the same, method for preparing the same, and a pharmaceutical composition for the treatment of respiratory tract disease or brain disfunction comprising the effective amount of same.摘要翻译： 具有由下式（I）和（II）表示的支气管扩张和脑功能改善活性的新颖的黄嘌呤化合物：其中R 1表示氢原子，4-甲氧基苄基，直链或支链烷基 具有1至6个碳原子的基团或具有3至6个碳原子的环烷基; R 2表示氢原子，具有1〜6个碳原子的直链或支链烷基或具有3〜6个碳原子的环烷基; n表示1〜4的整数， 和A表示-COCH 3或-C（OR 3）（OR 4））CH 3，其中R 3和R 4独立地表示具有1至3个碳原子的烷基或R 3与 R 4表示碳原子数2〜4的多亚甲基。 还公开了其药学上可接受的盐，其制备方法和用于治疗呼吸道疾病或脑功能障碍的药物组合物，其包含其有效量。
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3.发明公开
公开(公告)号：EP0393538A3
公开(公告)日：1991-09-25
申请号：EP90107124.1
申请日：1990-04-13
发明人： Itoh, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Ogawa, Nobuo , Yagi, Noriyuki , Yoshida, Toshihiko , Suzuki, Tomio
IPC分类号： C07D513/04 , A61K31/435
CPC分类号： C07D513/04
摘要： A thiazetoquinoline-3-carboxylic acid derivative represented by the general formula (I)
wherein R₁ is a hydrogen atom or a lower alkyl group; R₂ is a fluorine atom or a chlorine atom; R₃ is a hydrogen atom, a lower alkyl group, a lower alkanoyl group, a halogenated lower alkanoyl, or alkoxycarbonyl group; and R₄ is a hydrogen atom or a lower alkyl group, and a pharmacologically acceptable salt thereof, a process for preparation thereof, a pharmaceutical composition comprising the same, and a method for the treatment of an infectious disease by administering the same, are disclosed.-
4.发明公开Thiazetoquinoline-3-Carboxylic acid derivative, method for preparation thereof, and a pharmaceutical composition comprising the same 失效Thiazetochinolin -3-羧酸衍生物，它们的制备方法和含有药物制备方法。
公开(公告)号：EP0393538A2
公开(公告)日：1990-10-24
申请号：EP90107124.1
申请日：1990-04-13
发明人： Itoh, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Ogawa, Nobuo , Yagi, Noriyuki , Yoshida, Toshihiko , Suzuki, Tomio
IPC分类号： C07D513/04 , A61K31/435
CPC分类号： C07D513/04
摘要： A thiazetoquinoline-3-carboxylic acid derivative represented by the general formula (I)
wherein R₁ is a hydrogen atom or a lower alkyl group; R₂ is a fluorine atom or a chlorine atom; R₃ is a hydrogen atom, a lower alkyl group, a lower alkanoyl group, a halogenated lower alkanoyl, or alkoxycarbonyl group; and R₄ is a hydrogen atom or a lower alkyl group, and a pharmacologically acceptable salt thereof, a process for preparation thereof, a pharmaceutical composition comprising the same, and a method for the treatment of an infectious disease by administering the same, are disclosed.摘要翻译： 由通式（I）
worin R1表示的thiazetoquinoline -3-羧酸衍生物是一个氢原子或一个低级烷基; R2是氟原子或氯原子; R3是氢原子，低级烷基，低级烷酰基，卤代低级烷酰基，或烷氧羰基; 并且R 4是一个氢原子或低级烷基，以及它们的药理学上可接受的盐，用于制备方法及其，一种药物组合物相同，并且通过给予相同的用于感染性疾病的治疗方法中，光盘游离缺失。 -
5.发明公开Optically active thiazetoquino-line-3-carboxylic acid compound, method for preparation thereof, and a pharmaceutical composition comprising the same 失效光学活性Thiazetochinolin -3-羧酸化合物，它们的制备方法和含有药物组合物。
公开(公告)号：EP0465716A1
公开(公告)日：1992-01-15
申请号：EP90119802.8
申请日：1990-10-16
发明人： Ito, Yasuo , Kato, Hideo , Koshinaka, Eiichi , Ogawa, Nobuo , Yagi, Noriyuki , Yoshida, Toshihiko , Suzuki, Tomio
IPC分类号： C07D513/04 , A61K31/435
CPC分类号： C07D513/04
摘要： An optically active thiazetoquinoline-3-carboxylic acid compound represented by the following formula (I):
wherein R¹ is a hydrogen atom or a lower alkyl group; R² is a fluorine atom or a chlorine atom; R³ is a hydrogen atom, a lower alkanoyl group, a halogenated lower alkanoyl, or the residue of carboxylic acid ester; and C * represents an asymmetric carbon atom of S- or R-configuration, a pharmacologically acceptable salt thereof, and a method for preparing the compound are disclosed. Also disclosed are antibacterial agent, antineoplastic agent, and anti-AIDS virus agent comprising the same, a pharmaceutical composition for the treatment of bacterial infectious disease, tumor, and AIDS comprising an effective amount of the same.摘要翻译： 光学活性thiazetoquinoline -3-羧酸的由下式（I）表示的酸化合物：
worin - [R <1>是一个氢原子或一个低级烷基; [R <2>为氟原子或氯原子; [R <3>是氢原子，低级链烷酰基，卤代低级烷酰基，或羧酸酯的残基; 和C * darstellt到S-的不对称碳原子或R构型，或其药理学可接受的盐，以及制备该化合物的方法进行游离缺失光盘。 所以圆盘游离缺失是抗菌剂，抗肿瘤剂和抗艾滋病病毒剂，其包含相同的，用于细菌感染性疾病，肿瘤的治疗的药物组合物，和有效量的相同的艾滋病，包括 -
6.发明公开Xanthine compound, method for preparing thereof, and a pharmaceutical composition comprising the same 失效黄嘌呤化合物，涉及它们的制备和含有它们的药物制剂的方法。
公开(公告)号：EP0430025A2
公开(公告)日：1991-06-05
申请号：EP90122146.5
申请日：1990-11-20
IPC分类号： C07D473/06 , A61K31/52
CPC分类号： C07D473/04
摘要： A novel xanthine compound having bronchodilating and brain function improving activity represented by the following formula (I) and (II):
wherein R¹ represents a hydrogen atom, 4-methoxybenzyl group, a straight- or branched-chain alkyl group having 1 to 6 carbon atoms, or a cycloalkyl group having 3 to 6 carbon atoms; R² represents a hydrogen atom, a straight- or branched-chain alkyl group having 1 to 6 carbon atoms, or a cycloalkyl group having 3 to 6 carbon atoms; n represents an integer of from 1 to 4; and A represents -COCH₃ or - C(OR³)(OR⁴)CH₃ in which R³ and R⁴ independently represents an alkyl group having 1 to 3 carbon atoms or R³ together with R⁴ represents a polymethylene group having 2 to 4 carbon atoms is disclosed. Also disclosed are a pharmacologically acceptable salt of the same, method for preparing the same, and a pharmaceutical composition for the treatment of respiratory tract disease or brain disfunction comprising the effective amount of same.摘要翻译：
worin - [R <1> darstellt为氢原子，4-甲氧基苄基，直链或支链烷基：具有支气管扩张和脑功能改善用下式（I）表示的活性和（II）的新型黄嘌呤化合物 具有1至6个碳原子，或具有3至6个碳原子的环烷基基团; [R <2>代表氢原子，具有1至6个碳原子，或具有3至6个碳原子的环烷基的直链或支链烷基; Ñdarstellt从1至4的整数; 和A darstellt -COCH 3或 - C（OR <3>）（OR <4>）CH 3，其中R <3>和R <4>具有1至3个碳原子或R烷基的unabhängigdarstellt <3>连同 [R <4> darstellt具有聚亚甲基2至4个碳原子被游离缺失盘。 所以圆盘游离缺失可用于制备相同的是相同的，方法的药理学上可接受的盐，以及用于呼吸道疾病或脑功能障碍的包含有效量的相同治疗的药物组合物。 -
7.发明公开A 6-fluoro-1,4-dihydro-4-oxo-7-substituted piperazinyl-quinoline-3-carboxylic acid derivative and the method for preparing the same 失效A 6氟-1,4-二氢-4-氧代-7-取代Piperazinylchinolin -3-羧酸衍生物及其制备方法。
公开(公告)号：EP0140116A1
公开(公告)日：1985-05-08
申请号：EP84111035.6
申请日：1984-09-15
发明人： Itoh, Yasuo , Kato, Hideo , Ogawa, Nobuo , Koshinaka, Eiichi , Suzuki, Tomio , Yagi, Noriyuki
IPC分类号： C07D401/04 , A61K31/47
CPC分类号： C07D215/56
摘要： The invention is concerned with the novel piperazinyl- quinoline-3-carboxylic acid derivatives represented by formula (I)
or a pharmacologically-acceptable salt thereof, a process for the preparation of them, and a pharmaceutical composition which contains these new compounds as active ingredient and can be used as the therapeutic agent against bacteria.
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