公开(公告)号：EP4234554A2

公开(公告)日：2023-08-30

申请号：EP23160938.9

申请日：2017-06-19

申请人： Incyte Corporation

发明人： CHEN, Shili ,  JIA, Zhongjiang ,  LIU, Pingli ,  QIAO, Lei ,  WU, Yongzhong ,  ZHOU, Jiacheng ,  LI, Qun

IPC分类号： C07D471/04

摘要： The present application relates to crystalline solid forms of an inhibitor of BET proteins such as BRD2, BRD3, BRD4, and BRD-t, including methods of preparation thereof, and intermediates in the preparation thereof, where the compound is useful in the treatment of diseases such as cancer.

公开(公告)号：EP2300455A2

公开(公告)日：2011-03-30

申请号：EP09751439.2

申请日：2009-05-20

申请人： Incyte Corporation

发明人： WENG, Lingkai ,  QIAO, Lei ,  ZHOU, Jiacheng ,  LIU, Pingli ,  PAN, Yongchun

IPC分类号： C07D401/10 ,  C07D487/04 ,  C07D253/07 ,  A61K31/53 ,  A61P35/00

CPC分类号： A61K31/53 ,  C07D253/07 ,  C07D401/10 ,  C07D487/04

摘要： The present invention is directed to dihydrochloric acid and dibenzenesulfonic acid salts of the c-Met kinase inhibitor 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and pharmaceutical compositions thereof, useful in the treatment of cancer and other diseases related to the dysregulation of kinase pathways. The present invention further relates to processes and intermediates for preparing 2-fluoro-N-methyl-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide, and salts thereof.

摘要翻译： 本发明涉及的dihydrochloric c-Met激酶抑制剂2-氟-N-甲基-4- [7-（喹啉-6-基甲基）咪唑并[1,2-B] [1的酸和二苯酸盐 1,2,4]三嗪-2-基]苯甲酰胺，以及它们的药物组合物，在治疗癌症和相关激酶途径的失调的其他疾病的治疗。 本发明还涉及方法和中间体制备2-氟-N-甲基-4- [7-（喹啉-6-基甲基）咪唑并[1,2-B] [1,2,4]三嗪-2- 基]苯甲酰胺，和它们的盐。

公开(公告)号：EP3831833A1

公开(公告)日：2021-06-09

申请号：EP20201979.0

申请日：2016-02-26

申请人： Incyte Corporation

发明人： QIAO, Lei ,  WENG, Lingkai ,  SHI, ChongSheng Eric ,  MELONI, David ,  LIN, Qiyan ,  XIA, Michael ,  SHARIEF, Vaqar ,  FRIETZE, William ,  JIA, Zhongjiang ,  PAN, Yongchun ,  LIU, Pingli ,  YUE, Tai-Yuen ,  ZHOU, Jiacheng

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00

摘要： The present application provides processes for preparing ( R )-4-(3-(( S )-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3Kδ), as well as a salt form and intermediates related thereto.

公开(公告)号：EP3262046A1

公开(公告)日：2018-01-03

申请号：EP16718921.6

申请日：2016-02-26

申请人： Incyte Corporation

发明人： QIAO, Lei ,  WENG, Lingkai ,  SHI, ChongSheng Eric ,  MELONI, David ,  LIN, Qiyan ,  XIA, Michael ,  SHARIEF, Vaqar ,  FRIETZE, William ,  JIA, Zhongjiang ,  PAN, Yongchun ,  LIU, Pingli ,  YUE, Tai-Yuen ,  ZHOU, Jiacheng

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00

摘要： The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo [3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3Kδ), as well as a salt form and intermediates related thereto.

公开(公告)号：EP3262046B1

公开(公告)日：2020-11-04

申请号：EP16718921.6

申请日：2016-02-26

申请人： Incyte Corporation

发明人： QIAO, Lei ,  WENG, Lingkai ,  SHI, ChongSheng Eric ,  MELONI, David ,  LIN, Qiyan ,  XIA, Michael ,  SHARIEF, Vaqar ,  FRIETZE, William ,  JIA, Zhongjiang ,  PAN, Yongchun ,  LIU, Pingli ,  YUE, Tai-Yuen ,  ZHOU, Jiacheng

IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00

公开(公告)号：EP3472157A1

公开(公告)日：2019-04-24

申请号：EP17734590.7

申请日：2017-06-19

申请人： Incyte Corporation

发明人： CHEN, Shili ,  JIA, Zhongjiang ,  LIU,Pingli ,  QIAO, Lei ,  WU, Yongzhong ,  ZHOU, Jiacheng ,  LI, Qun

IPC分类号： C07D471/02

公开(公告)号：EP3347351A1

公开(公告)日：2018-07-18

申请号：EP16770411.3

申请日：2016-09-09

申请人： Incyte Corporation

发明人： JIA, Zhongjiang ,  CAO, Ganfeng ,  LIN, Qiyan ,  PAN, Yongchun ,  QIAO, Lei ,  SHARIEF, Vaqar ,  SHI, ChongSheng Eric ,  XIA, Michael ,  ZHENG, Changsheng ,  ZHOU, Jiacheng ,  LI, Qun

IPC分类号： C07D401/14 ,  C07D215/60 ,  C07D401/12 ,  C07F7/18 ,  A61K31/4709 ,  A61P35/00 ,  C07D221/18

CPC分类号： C07D401/14 ,  A61K31/4545 ,  C07B2200/13 ,  C07D401/12 ,  C07F7/1804

摘要： The present invention relates to salt forms of the Pim kinase inhibitor N-{(7R)-4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide, including methods of preparation thereof, and intermediates in the preparation thereof, where the compound is useful in the treatment of Pim kinase-related diseases such as cancer.

公开(公告)号：EP4234554A3

公开(公告)日：2023-12-27

申请号：EP23160938.9

申请日：2017-06-19

申请人： Incyte Corporation

发明人： CHEN, Shili ,  JIA, Zhongjiang ,  LIU, Pingli ,  QIAO, Lei ,  WU, Yongzhong ,  ZHOU, Jiacheng ,  LI, Qun

IPC分类号： C07D471/04 ,  A61K31/538 ,  A61P35/00

摘要： The present application relates to crystalline solid forms of an inhibitor of BET proteins such as BRD2, BRD3, BRD4, and BRD-t, including methods of preparation thereof, and intermediates in the preparation thereof, where the compound is useful in the treatment of diseases such as cancer.

公开(公告)号：EP3137471A1

公开(公告)日：2017-03-08

申请号：EP15724406.2

申请日：2015-04-29

申请人： Incyte Corporation

发明人： ZHOU, Jiacheng ,  LIU, Pingli ,  CHEN, Shili ,  WU, Yongzhong ,  WANG, Dengjin ,  JIA, Zhongjiang ,  QIAO, Lei ,  FRIETZE, William ,  XIA, Michael ,  DAI, Yingrui

IPC分类号： C07D495/14 ,  A61K31/437 ,  A61P25/00 ,  A61P35/00 ,  A61P37/00

CPC分类号： C07D495/14 ,  C07D309/14 ,  C07D495/04

摘要： This invention relates to processes for preparing a JAK1 inhibitor having Formula Ia: as well as new forms of the inhibitor.

摘要翻译： 本发明涉及用于制备具有式Ia一个JAK1抑制剂：以及所述抑制剂的新形式。