专利检索 ap:("Incyte Corporation") AND inv:"FRIETZE, William" 第 1 页

1.

发明公开
PROCESSES OF PREPARING A JAK1 INHIBITOR AND NEW FORMS THERETO 审中-公开
标题翻译： PROCESS其制造JAK1抑制剂和新形式

公开(公告)号：EP3137471A1

公开(公告)日：2017-03-08

申请号：EP15724406.2

申请日：2015-04-29

申请人： Incyte Corporation

发明人： ZHOU, Jiacheng , LIU, Pingli , CHEN, Shili , WU, Yongzhong , WANG, Dengjin , JIA, Zhongjiang , QIAO, Lei , FRIETZE, William , XIA, Michael , DAI, Yingrui

IPC分类号： C07D495/14 , A61K31/437 , A61P25/00 , A61P35/00 , A61P37/00

CPC分类号： C07D495/14 , C07D309/14 , C07D495/04

摘要： This invention relates to processes for preparing a JAK1 inhibitor having Formula Ia: as well as new forms of the inhibitor.

摘要翻译： 本发明涉及用于制备具有式Ia一个JAK1抑制剂：以及所述抑制剂的新形式。

2.

发明公开
SOLID FORMS OF AN FGFR INHIBITOR AND PROCESSES FOR PREPARING THE SAME 审中-公开

公开(公告)号：EP4309737A2

公开(公告)日：2024-01-24

申请号：EP23197192.0

申请日：2019-05-03

申请人： Incyte Corporation

发明人： BURN, Timothy C. , LIU, Phillip C. , FRIETZE, William , JIA, Zhongjiang , TAO, Ming , WANG, Dengjin , ZHOU, Jiacheng , LI, Qun

IPC分类号： A61P35/00

摘要： The present disclosure relates to 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, solid forms and polymorphs thereof, methods of preparation thereof, and intermediates in the preparation thereof, which are useful in the treatment of the FGFR-associated or mediated diseases such as cancer.

3.

发明公开
SOLID FORMS OF AN FGFR INHIBITOR AND PROCESSES FOR PREPARING THE SAME 审中-公开

公开(公告)号：EP3788047A2

公开(公告)日：2021-03-10

申请号：EP19724676.2

申请日：2019-05-03

申请人： Incyte Corporation

发明人： BURN, Timothy C. , LIU, Phillip C. , FRIETZE, William , JIA, Zhongjiang , TAO, Ming , WANG, Dengjin , ZHOU, Jiacheng , LI, Qun

IPC分类号： C07D471/14 , A61K31/519 , A61P35/00

4.

发明公开
SOLID FORMS OF AN HPK1 INHIBITOR 审中-公开

公开(公告)号：EP4010338A1

公开(公告)日：2022-06-15

申请号：EP20760996.7

申请日：2020-08-05

申请人： Incyte Corporation

发明人： JIA, Zhongjiang , FRIETZE, William

IPC分类号： C07D403/12 , A61P35/00 , A61K31/506

5.

发明公开
PROCESSES FOR THE PREPARATION OF A PI3K INHIBITOR 审中-公开

公开(公告)号：EP3831833A1

公开(公告)日：2021-06-09

申请号：EP20201979.0

申请日：2016-02-26

申请人： Incyte Corporation

发明人： QIAO, Lei , WENG, Lingkai , SHI, ChongSheng Eric , MELONI, David , LIN, Qiyan , XIA, Michael , SHARIEF, Vaqar , FRIETZE, William , JIA, Zhongjiang , PAN, Yongchun , LIU, Pingli , YUE, Tai-Yuen , ZHOU, Jiacheng

IPC分类号： C07D487/04 , A61K31/519 , A61P35/00

摘要： The present application provides processes for preparing ( R )-4-(3-(( S )-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3Kδ), as well as a salt form and intermediates related thereto.

6.

发明公开
SALTS OF PI3K INHIBITOR AND PROCESSES FOR THEIR PREPARATION 审中-公开
标题翻译： PI3K抑制剂的盐及其制备方法

公开(公告)号：EP3262046A1

公开(公告)日：2018-01-03

申请号：EP16718921.6

申请日：2016-02-26

申请人： Incyte Corporation

发明人： QIAO, Lei , WENG, Lingkai , SHI, ChongSheng Eric , MELONI, David , LIN, Qiyan , XIA, Michael , SHARIEF, Vaqar , FRIETZE, William , JIA, Zhongjiang , PAN, Yongchun , LIU, Pingli , YUE, Tai-Yuen , ZHOU, Jiacheng

IPC分类号： C07D487/04 , A61K31/519 , A61P35/00

摘要： The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo [3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3Kδ), as well as a salt form and intermediates related thereto.

7.

发明公开
SOLID FORMS OF AN FGFR INHIBITOR AND PROCESSES FOR PREPARING THE SAME 审中-实审

公开(公告)号：EP4309737A3

公开(公告)日：2024-03-27

申请号：EP23197192.0

申请日：2019-05-03

申请人： Incyte Corporation

发明人： BURN, Timothy C. , LIU, Phillip C. , FRIETZE, William , JIA, Zhongjiang , TAO, Ming , WANG, Dengjin , ZHOU, Jiacheng , LI, Qun

IPC分类号： C07D471/14 , A61K31/519 , A61P35/00

摘要： The present disclosure relates to 3-(2,6-difluoro-3,5-dimethoxyphenyl)-1-ethyl-8-(morpholin-4-ylmethyl)-1,3,4,7-tetrahydro-2H-pyrrolo[3',2':5,6]pyrido[4,3-d]pyrimidin-2-one, solid forms and polymorphs thereof, methods of preparation thereof, and intermediates in the preparation thereof, which are useful in the treatment of the FGFR-associated or mediated diseases such as cancer.

8.

发明授权
SALTS OF PI3K INHIBITOR AND PROCESSES FOR THEIR PREPARATION 有权

公开(公告)号：EP3262046B1

公开(公告)日：2020-11-04

申请号：EP16718921.6

申请日：2016-02-26

申请人： Incyte Corporation

发明人： QIAO, Lei , WENG, Lingkai , SHI, ChongSheng Eric , MELONI, David , LIN, Qiyan , XIA, Michael , SHARIEF, Vaqar , FRIETZE, William , JIA, Zhongjiang , PAN, Yongchun , LIU, Pingli , YUE, Tai-Yuen , ZHOU, Jiacheng

IPC分类号： C07D487/04 , A61K31/519 , A61P35/00

9.

发明公开
SALTS OF AN LSD1 INHIBITOR 审中-公开

公开(公告)号：EP3334709A1

公开(公告)日：2018-06-20

申请号：EP16754092.1

申请日：2016-08-11

申请人： Incyte Corporation

发明人： LI, Qun , PAN, Yongchun , HAN, Wayne , CAO, Ganfeng , FRIETZE, William , JIA, Zhongjiang , SHARIEF, Vaqar , ZHOU, Jiacheng

IPC分类号： C07D211/26 , C07D211/32 , A61K31/44

CPC分类号： C07D211/26 , C07D211/22 , C07D211/32

摘要： The present disclosure relates to tosylate salts 1-{[4-(methoxymethyl)-4-({[(1R,2S)-2-phenylcyclopropyl]amino}methyl)piperidin-1-yl]methyl}cyclobutanecarboxylic acid, methods of preparation thereof, and intermediates in the preparation thereof, which are useful in the treatment of the LSD1-associated or mediated diseases such as cancer.