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1.发明授权
公开(公告)号：EP2315756B9
公开(公告)日：2015-07-22
申请号：EP09790108.6
申请日：2009-07-07
申请人： Incyte Corporation
发明人： COMBS, Andrew, P. , YUE, Eddy, W. , SPARKS, Richard, B. , ZHU, Wenyu , ZHOU, Jiacheng , LIN, Qiyan , WENG, Lingkai , YUE, Tai-Yuen , LIU, Pingli
IPC分类号： C07D271/08 , A61K31/4245 , A61P1/00 , A61P11/00 , A61P17/00 , A61P19/00 , A61P25/00 , A61P27/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P43/00
CPC分类号： A61K31/4245 , A61K39/0011 , A61K39/3955 , C07D271/08 , C07D413/04 , C07D413/12
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2.发明授权
公开(公告)号：EP2315756B1
公开(公告)日：2014-09-03
申请号：EP09790108.6
申请日：2009-07-07
申请人： Incyte Corporation
发明人： COMBS, Andrew, P. , YUE, Eddy, W. , SPARKS, Richard, B. , ZHU, Wenyu , ZHOU, Jiacheng , LIN, Qiyan , WENG, Lingkai , YUE, Tai-Yuen , LIU, Pingli
IPC分类号： C07D271/08 , A61K31/4245 , A61P1/00 , A61P11/00 , A61P17/00 , A61P19/00 , A61P25/00 , A61P27/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P43/00
CPC分类号： A61K31/4245 , A61K39/0011 , A61K39/3955 , C07D271/08 , C07D413/04 , C07D413/12
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3.发明公开
公开(公告)号：EP2315756A2
公开(公告)日：2011-05-04
申请号：EP09790108.6
申请日：2009-07-07
申请人： Incyte Corporation
发明人： COMBS, Andrew, P. , YUE, Eddy, W. , SPARKS, Richard, B. , ZHU, Wenyu , ZHOU, Jiacheng , LIN, Qiyan , WENG, Lingkai , YUE, Tai-Yuen , LIU, Pingli
IPC分类号： C07D271/08 , A61K31/4245 , A61P1/00 , A61P11/00 , A61P17/00 , A61P19/00 , A61P25/00 , A61P27/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P43/00
CPC分类号： A61K31/4245 , A61K39/0011 , A61K39/3955 , C07D271/08 , C07D413/04 , C07D413/12
摘要： The present invention is directed to 1,2,5-oxadiazole derivatives, and compositions of the same, which are inhibitors of indoleamine 2,3-dioxygenase and are useful in the treatment of cancer and other disorders, and to the processes and intermediates for making such 1,2,5-oxadiazole derivatives. The present invention provides,
inter alia , IDO inhibitors of Formula I: or a pharmaceutically acceptable salt thereof, wherein: R
1 is NH
2 or CH
3 ; R
2 is C1, Br, CF
3 , CH
3 , or CN; R
3 is H or F; and n is 1 or 2.-
公开(公告)号：EP3831833A1
公开(公告)日：2021-06-09
申请号：EP20201979.0
申请日：2016-02-26
申请人： Incyte Corporation
发明人： QIAO, Lei , WENG, Lingkai , SHI, ChongSheng Eric , MELONI, David , LIN, Qiyan , XIA, Michael , SHARIEF, Vaqar , FRIETZE, William , JIA, Zhongjiang , PAN, Yongchun , LIU, Pingli , YUE, Tai-Yuen , ZHOU, Jiacheng
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
摘要： The present application provides processes for preparing ( R )-4-(3-(( S )-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3Kδ), as well as a salt form and intermediates related thereto.
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公开(公告)号：EP3262046A1
公开(公告)日：2018-01-03
申请号：EP16718921.6
申请日：2016-02-26
申请人： Incyte Corporation
发明人： QIAO, Lei , WENG, Lingkai , SHI, ChongSheng Eric , MELONI, David , LIN, Qiyan , XIA, Michael , SHARIEF, Vaqar , FRIETZE, William , JIA, Zhongjiang , PAN, Yongchun , LIU, Pingli , YUE, Tai-Yuen , ZHOU, Jiacheng
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
摘要： The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo [3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3Kδ), as well as a salt form and intermediates related thereto.
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6.发明公开
公开(公告)号：EP2398774A2
公开(公告)日：2011-12-28
申请号：EP10700665.2
申请日：2010-01-14
申请人： Incyte Corporation
发明人： ZHOU, Jiacheng , LIU, Pingli , LIN, Qiyan , METCALF, Brian, W. , MELONI, David , PAN, Yongchun , XIA, Michael , LI, Mei , YUE, Tai-Yuen , RODGERS, James, D. , WANG, Haisheng
IPC分类号： C07D231/16 , C07D487/04 , C07F5/04 , C07F7/08
CPC分类号： C07D487/04 , C07F5/025 , C07F7/083 , C07F7/10 , C07F7/1892 , Y02P20/55
摘要： The present invention is related to processes for preparing chiral substituted pyrazolyl pyrrolo[2,3- d ]pyrimidines of Formula III, and related synthetic intermediate compounds. The chiral substituted pyrazolyl pyrrolo[2,3- d ]pyrimidines are useful as inhibitors of the Janus Kinase family of protein tyrosine kinases (JAKs) for treatment of inflammatory diseases, myeloproliferative disorders, and other diseases.
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公开(公告)号：EP3262046B1
公开(公告)日：2020-11-04
申请号：EP16718921.6
申请日：2016-02-26
申请人： Incyte Corporation
发明人： QIAO, Lei , WENG, Lingkai , SHI, ChongSheng Eric , MELONI, David , LIN, Qiyan , XIA, Michael , SHARIEF, Vaqar , FRIETZE, William , JIA, Zhongjiang , PAN, Yongchun , LIU, Pingli , YUE, Tai-Yuen , ZHOU, Jiacheng
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00
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