公开(公告)号：EP1504101A2

公开(公告)日：2005-02-09

申请号：EP02786702.7

申请日：2002-11-07

申请人： Incyte Genomics, Inc.

发明人： KABLE, Amy, E. ,  SWARNAKAR, Anita ,  GORVAD, Ann, E. ,  HAFALIA, April, J.A. ,  DUGGAN, Brendan, M. ,  WARREN, Bridget, A. ,  EMERLING, Brooke, M. ,  ISON, Craig, H. ,  NGUYEN, Danniel, B. ,  LINDQUIST, Erika, A. ,  LEE, Ernestine, A. ,  YUE, Henry ,  YUE, Huibin ,  FORSYTHE, Ian, J. ,  RAMKUMAR, Jayalaxmi ,  GRIFFIN, Jennifer, A. ,  LI, Joana, X. ,  MARQUIS, Joseph, P. ,  GIETZEN, Kimberly, J. ,  BAUGHN, Mariah R. ,  BOROWSKY, Mark L. ,  YAO, Monique G. ,  CHAWLA, Narinder K. ,  LEHR-MASON, Patricia M. ,  LAL, Preeti G. ,  GURURAJAN, Rajagopal ,  KHARE, Reena ,  BATRA, Sajeev ,  BECNA, Shanya, D. ,  LEE, Soo Yeun ,  TRAN, Uyen K. ,  ELLIOTT, Vicki S. ,  SPRAGUE, William W. ,  TANG, Y. Tom ,  ZEBARJADIAN, Yeganeh ,  JIANG, Xin ,  JACKSON, Alan A. ,  BHATIA, Umesh ,  BURRILL, John D. ,  LEE, Sally ,  BLAKE, Julie J. ,  HO, Anne ,  ZHENG, Wenjin

IPC分类号： C12N15/63 ,  C12N15/85 ,  C07K14/00 ,  C07K16/00

CPC分类号： C07K14/47

摘要： Various ernbodiments of the invention provide human intracellular signaling molecules (INTSIG) and polynucleotides which identify and encode INTSIG. Embodiments of the invention also provide expression vectors, host cells, antibodies, agonists, and antagonists. Other embodiments provide methods for diagnosing, treating, or preventing disorders associated with aberrant expression of INTSIG.