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    ANTIBODY HAVING INHIBITORY ACTIVITY ON INFECTION WITH HEPATITIS C VIRUS (HCV), AND USE THEREOF
    3.
    发明公开
    ANTIBODY HAVING INHIBITORY ACTIVITY ON INFECTION WITH HEPATITIS C VIRUS (HCV), AND USE THEREOF 审中-公开
    对丙型肝炎病毒（HCV）感染具有抑制活性的抗体及其用途

    公开(公告)号：EP2177535A1

    公开(公告)日：2010-04-21

    申请号：EP08791668.0

    申请日：2008-07-25

    申请人： JAPAN as represented by DIRECTOR GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES ,  TORAY INDUSTRIES, INC.

    发明人： WAKITA, Takaji ,  SUZUKI, Tetsuro ,  MORIKAWA, Kenichi ,  OMI, Noriaki ,  NAKAMURA, Noriko ,  AKAZAWA, Daisuke

    IPC分类号： C07K16/10 ,  A61K39/395 ,  A61P31/14 ,  C12N15/09 ,  G01N33/53 ,  G01N33/576 ,  C12P21/08

    CPC分类号： C07K16/109 ,  C07K14/005 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C12N2770/24222 ,  G01N2333/186

    摘要： The objection of the invention is to provide an antibody that inhibits infection with hepatitis C virus (HCV). To this end, this invention provides an antibody that recognizes the hepatitis C virus (HCV) particle obtained from the hepatitis C virus (HCV) genome comprising the following (i) and (ii) ligated to each other as an antigen and has an inhibitory activity on infection with hepatitis C virus (HCV): (i) (a) the 5'-untranslated region, the core protein-encoding sequence, the E1 protein-encoding sequence, the E2 protein-encoding sequence, and the p7 protein-encoding sequence of the JFH-1 strain of the hepatitis C virus (HCV) or (b) the 5'-untranslated region, the core protein-encoding sequence, the E1 protein-encoding sequence, the E2 protein-encoding sequence, and the p7 protein-encoding sequence of the J6CF strain the hepatitis C virus (HCV); and (ii) the NS2 protein-encoding sequence, the NS3 protein-encoding sequence, the NS4A protein-encoding sequence, the NS4B protein-encoding sequence, the NS5A protein-encoding sequence, the NS5B protein-encoding sequence, and the 3'-untranslated region of the JFH-1 strain.

    摘要翻译： 本发明的目的是提供抑制丙型肝炎病毒（HCV）感染的抗体。 为此，本发明提供了一种识别从丙型肝炎病毒（HCV）基因组获得的包含以下（i）和（ii）的丙型肝炎病毒（HCV）颗粒作为抗原并且具有抑制性 （HCV）感染的活性：（i）（a）5'-非翻译区，核心蛋白编码序列，E1蛋白编码序列，E2蛋白编码序列和p7蛋白编码序列， （HCV）的JFH-1株的编码序列或（b）5'非翻译区，核心蛋白编码序列，E1蛋白编码序列，E2蛋白编码序列和 丙型肝炎病毒（HCV）的J6CF株的p7蛋白编码序列; 和（ii）NS2蛋白编码序列，NS3蛋白编码序列，NS4A蛋白编码序列，NS4B蛋白编码序列，NS5A蛋白编码序列，NS5B蛋白编码序列和3' - JFH-1菌株的非翻译区。

    MONOCLONAL ANTIBODY, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF
    4.
    发明公开
    MONOCLONAL ANTIBODY, PROCESS FOR PRODUCING THE SAME, AND USE THEREOF 失效
    MONOKLONALEANTIKÖRPER，ANWENDUNG UND VERFAHREN ZUR HERSTELLUNG。

    公开(公告)号：EP0667395A1

    公开(公告)日：1995-08-16

    申请号：EP94917140.9

    申请日：1994-06-01

    申请人： TORAY INDUSTRIES, INC.

    发明人： NISHIKAWA, Satomi ,  SUDO, Tetsuo, Toray Industries Residence I-1 ,  OKANO, Kiyoshi ,  IZAWA, Akiko ,  NAKAMURA, Noriko ,  AKIYAMA, Naoko

    IPC分类号： C12P21/08 ,  C07K15/28 ,  G01N33/577 ,  G01N33/53 ,  A01K67/027 ,  C12N5/06

    CPC分类号： C07K16/2866 ,  A01K67/027 ,  A61K38/00

    摘要： 5 n7 A monoclonal antibody specific for mouse IL-7 receptors, and an immunoassay method by which the receptors can be detected and determined readily with high sensitivity and accuracy. An artifically induced model prepared by administering the above antibody to an animal can be utilized in elucidating the mechanism of lymphocyte differentiation and proliferation, developing an immunosuppressant, and investigating organ transplantation, arthritis, diabetes, and so forth. Further, an artifically induced model prepared by administering the above antibody in combination with an anti-SCF receptor antibody to an animal can be utilized in elucidating diseases due to an abnormal hematopoietic function such as aplastic anemia exhibiting decreased myelopoiesis and whole blood hematopenia in the peripheral blood and in developing medicines capable of curing these blood cell disorders. A mouse containing the above antibody in combination with an anti-SCF receptor antibody administered thereto has concentrated hematopoietic stem cells, and hence the myeloma or splenic cells thereof can be used to estimate hematopoietic stem cell proliferation factors. Therefore, the invention method of estimation is useful in searching for such factors.

    摘要翻译： 特异于小鼠IL-7受体的单克隆抗体，以及可以以高灵敏度和准确度容易地检测和确定受体的免疫测定方法。 通过向动物施用上述抗体而制备的人造诱发模型可用于阐明淋巴细胞分化和增殖的机制，开发免疫抑制剂，以及研究器官移植，关节炎，糖尿病等。 此外，通过将上述抗体与抗SCF受体抗体组合施用于动物而制备的专门诱导的模型可用于阐明由于造血功能异常引起的疾病，例如在外周期中显示骨髓细胞减少和全血血细胞减少的再生障碍性贫血 血液和开发能够治愈这些血细胞疾病的药物。 含有上述抗体与施用于其的抗SCF受体抗体组合的小鼠具有浓缩的造血干细胞，因此其骨髓瘤或脾细胞可用于估计造血干细胞增殖因子。 因此，本发明的估计方法在寻找这些因素方面是有用的。