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    NUCLEIC ACID CONTAINING CHIMERIC GENE DERIVED FROM HEPATITIS TYPE-C VIRUS
    2.
    发明公开
    NUCLEIC ACID CONTAINING CHIMERIC GENE DERIVED FROM HEPATITIS TYPE-C VIRUS 审中-公开
    NUKLEINSÄUREMIT AUS HEPATITIS-TYP-C-VIRUS STAMMENDEMCHIMÄREMGEN

    公开(公告)号：EP2281882A1

    公开(公告)日：2011-02-09

    申请号：EP09734063.2

    申请日：2009-04-24

    申请人： Toray Industries, Inc. ,  JAPAN as represented by DIRECTOR GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES ,  Tokyo Metropolitan Organization for Medical Research

    发明人： AKAZAWA, Daisuke ,  WAKITA, Takaji

    IPC分类号： C12N15/00 ,  C07K16/08 ,  C12N5/10 ,  C12N7/00 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/70

    CPC分类号： A61K39/29 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/5254 ,  C07K14/005 ,  C07K16/109 ,  C07K2319/00 ,  C12N7/00 ,  C12N2770/24222 ,  C12N2770/24234 ,  C12N2770/24251 ,  C12Q1/707 ,  C12Q2600/136 ,  C12Q2600/156

    摘要： This invention provides infectious chimeric HCV particles that can be used for vaccines. This invention further provides a nucleic acid comprising a chimeric gene derived from the hepatitis C virus comprising regions each encoding Core protein, E1 protein, E2 protein and p7 protein derived from a hepatitis C virus strain other than JFH-1 strain; NS2 protein derived from JFH-1 strain or a hepatitis C virus strain other than JFH-1 strain, or a chimeric NS2 protein of NS2 protein derived from JFH-1 strain and NS2 protein derived from a hepatitis C virus strain other than JFH-1 strain; and NS3 protein, NS4A protein, NS4B protein, NS5A protein, and NS5B protein derived from JFH-1 strain in that order in 5' to 3' direction, wherein the 328th proline residue from the amino acid residue at N-terminus of the Core protein is substituted with an amino acid residue other than proline. This invention further provides chimeric HCV particles comprising such nucleic acid, and use of such HCV particles for vaccines.

    摘要翻译： 本发明提供可用于疫苗的感染性嵌合HCV颗粒。 本发明还提供了包含源自丙型肝炎病毒的嵌合基因的核酸，其包含各自编码来自除了JFH-1株之外的丙型肝炎病毒株的核心蛋白质，E1蛋白质，E2蛋白质和p7蛋白质的区域; 衍生自JFH-1株或除JFH-1株以外的丙型肝炎病毒株的NS2蛋白或源自JFH-1株的NS2蛋白的嵌合NS2蛋白和来自除JFH-1以外的丙型肝炎病毒株的NS2蛋白 应变; 和NS3蛋白，NS4A蛋白，NS4B蛋白，NS5A蛋白和NS5B蛋白，其在5'至3'方向上按顺序从JFH-1菌株衍生，其中来自核心N末端的氨基酸残基的第328位脯氨酸残基 蛋白质被除脯氨酸以外的氨基酸残基取代。 本发明还提供了包含这种核酸的嵌合HCV颗粒，以及这种HCV颗粒用于疫苗的用途。

    ANTIBODY HAVING INHIBITORY ACTIVITY ON INFECTION WITH HEPATITIS C VIRUS (HCV), AND USE THEREOF
    3.
    发明公开
    ANTIBODY HAVING INHIBITORY ACTIVITY ON INFECTION WITH HEPATITIS C VIRUS (HCV), AND USE THEREOF 审中-公开
    对丙型肝炎病毒（HCV）感染具有抑制活性的抗体及其用途

    公开(公告)号：EP2177535A1

    公开(公告)日：2010-04-21

    申请号：EP08791668.0

    申请日：2008-07-25

    申请人： JAPAN as represented by DIRECTOR GENERAL OF NATIONAL INSTITUTE OF INFECTIOUS DISEASES ,  TORAY INDUSTRIES, INC.

    发明人： WAKITA, Takaji ,  SUZUKI, Tetsuro ,  MORIKAWA, Kenichi ,  OMI, Noriaki ,  NAKAMURA, Noriko ,  AKAZAWA, Daisuke

    IPC分类号： C07K16/10 ,  A61K39/395 ,  A61P31/14 ,  C12N15/09 ,  G01N33/53 ,  G01N33/576 ,  C12P21/08

    CPC分类号： C07K16/109 ,  C07K14/005 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C12N2770/24222 ,  G01N2333/186

    摘要： The objection of the invention is to provide an antibody that inhibits infection with hepatitis C virus (HCV). To this end, this invention provides an antibody that recognizes the hepatitis C virus (HCV) particle obtained from the hepatitis C virus (HCV) genome comprising the following (i) and (ii) ligated to each other as an antigen and has an inhibitory activity on infection with hepatitis C virus (HCV): (i) (a) the 5'-untranslated region, the core protein-encoding sequence, the E1 protein-encoding sequence, the E2 protein-encoding sequence, and the p7 protein-encoding sequence of the JFH-1 strain of the hepatitis C virus (HCV) or (b) the 5'-untranslated region, the core protein-encoding sequence, the E1 protein-encoding sequence, the E2 protein-encoding sequence, and the p7 protein-encoding sequence of the J6CF strain the hepatitis C virus (HCV); and (ii) the NS2 protein-encoding sequence, the NS3 protein-encoding sequence, the NS4A protein-encoding sequence, the NS4B protein-encoding sequence, the NS5A protein-encoding sequence, the NS5B protein-encoding sequence, and the 3'-untranslated region of the JFH-1 strain.

    摘要翻译： 本发明的目的是提供抑制丙型肝炎病毒（HCV）感染的抗体。 为此，本发明提供了一种识别从丙型肝炎病毒（HCV）基因组获得的包含以下（i）和（ii）的丙型肝炎病毒（HCV）颗粒作为抗原并且具有抑制性 （HCV）感染的活性：（i）（a）5'-非翻译区，核心蛋白编码序列，E1蛋白编码序列，E2蛋白编码序列和p7蛋白编码序列， （HCV）的JFH-1株的编码序列或（b）5'非翻译区，核心蛋白编码序列，E1蛋白编码序列，E2蛋白编码序列和 丙型肝炎病毒（HCV）的J6CF株的p7蛋白编码序列; 和（ii）NS2蛋白编码序列，NS3蛋白编码序列，NS4A蛋白编码序列，NS4B蛋白编码序列，NS5A蛋白编码序列，NS5B蛋白编码序列和3' - JFH-1菌株的非翻译区。

    MODIFIED HUMAN HEPATITIS C VIRUS GENOMIC RNA HAVING AUTONOMOUS REPLICATIVE COMPETENCE
    9.
    发明公开
    MODIFIED HUMAN HEPATITIS C VIRUS GENOMIC RNA HAVING AUTONOMOUS REPLICATIVE COMPETENCE 有权
    修改后的人类丙型肝炎病毒基因组RNA具有自主复制能力

    公开(公告)号：EP1801209A1

    公开(公告)日：2007-06-27

    申请号：EP05781421.2

    申请日：2005-08-24

    申请人： Tokyo Metropolitan Organization for Medical Research ,  TORAY INDUSTRIES, INC.

    发明人： WAKITA, Takaji ,  KATO, Takanobu Eminence-Ishikawabashi 206 ,  DATE, Tomoko ,  MIYAMOTO, Michiko ,  BARTENSCHLAGER, Ralf ,  TANABE, Jun-ichi ,  SONE, Saburo

    IPC分类号： C12N15/09 ,  A61K39/29 ,  A61K48/00 ,  A61P1/16 ,  A61P31/14 ,  C12N5/10 ,  C12N7/00 ,  C12Q1/68 ,  C12Q1/70

    CPC分类号： C12N7/00 ,  A61K48/00 ,  A61K2039/525 ,  C12N15/86 ,  C12N2770/24221 ,  C12N2770/24243 ,  C12N2840/203 ,  C12Q1/6883

    摘要： The present invention provides modified hepatitis C virus genomic RNA, comprising nucleotide sequences of genomic RNA portions of two or more types of hepatitis C viruses, which comprises a 5' untranslated region, a core protein coding sequence, an E1 protein coding sequence, a p7 protein coding sequence, an E2 protein coding sequence, an NS2 protein coding sequence, an NS3 protein coding sequence, an NS4A protein coding sequence, an NS4B protein coding sequence, an NS5A protein coding sequence, an NS5B protein coding sequence, and a 3' untranslated region, and which can be autonomously replicated. In particular, the present invention relates to modified hepatitis C virus genomic RNA, which can be autonomously replicated by substitution of the RNA sequence portion encoding NS3, NS4, NS5A, and NS5B proteins of hepatitis C virus genomic RNA with a partial RNA sequence encoding NS3, NS4, NS5A, and NS5B proteins of a JFH1 strain shown in SEQ ID NO: 1.

    摘要翻译： 本发明提供经修饰的丙型肝炎病毒基因组RNA，其包含两种或更多种丙型肝炎病毒的基因组RNA部分的核苷酸序列，其包含5'非翻译区，核心蛋白编码序列，E1蛋白编码序列，p7 蛋白编码序列，E2蛋白编码序列，NS2蛋白编码序列，NS3蛋白编码序列，NS4A蛋白编码序列，NS4B蛋白编码序列，NS5A蛋白编码序列，NS5B蛋白编码序列和3' 非翻译区域，并且可以自主复制。 特别地，本发明涉及修饰的丙型肝炎病毒基因组RNA，其可通过用编码NS3的部分RNA序列取代编码丙型肝炎病毒基因组RNA的NS3，NS4，NS5A和NS5B蛋白的RNA序列部分而自主复制 ，SEQ ID NO：1所示的JFH1菌株的NS4，NS5A和NS5B蛋白。