公开(公告)号：EP1162269A1

公开(公告)日：2001-12-12

申请号：EP00905320.8

申请日：2000-02-24

申请人： KYOWA HAKKO KOGYO CO., LTD.

发明人： NARIMATSU, Hisashi ,  ISSHIKI, Soichiro ,  TOGAYACHI, Akira ,  SASAKI, Katsutoshi, Tokyo Research Laboratories

IPC分类号： C12N15/54 ,  C12P21/02 ,  C12N9/10 ,  C12N1/21 ,  C12N5/14 ,  C12N5/16 ,  C12Q1/68 ,  C12N15/63 ,  A01K67/027 ,  G01N33/15 ,  G01N33/50 ,  G01N33/574 ,  A01H5/00

CPC分类号： C12N9/1051 ,  A61K38/00 ,  A61K39/00 ,  C12P19/04

摘要： According to the present invention, there can be provided a novel polypeptide having β1,3-galactosyltransferase activity involved in the synthesis of type 1 sugar chains, a DNA coding for said polypeptide, a recombinant vector comprising said DNA, a transformant carrying said recombinant vector, a process for producing type 1 sugar chain-containing sugar chains and complex carbohydrates by use of said polypeptide or said transformant, an antibody recognizing said polypeptide, a method for detecting or quantifying said polypeptide by use of said antibody, a method for screening a substance correlated with said polypeptide, a method for diagnosis or treatment of cancers in the digestive system by use of said DNA or said antibody, and a method for treatment of cancers in the digestive system by use of a substance obtained by said screening method.

摘要翻译： 根据本发明，可以提供一种参与合成1型糖链的β1,3-半乳糖基转移酶活性的新型多肽，编码所述多肽的DNA，包含所述DNA的重组载体，携带所述重组体的转化体 载体，通过使用所述多肽或所述转化体产生含1糖链的糖链和复合碳水化合物的方法，识别所述多​​肽的抗体，通过使用所述抗体检测或定量所述多肽的方法，筛选方法 与所述多肽相关的物质，通过使用所述DNA或所述抗体在消化系统中诊断或治疗癌症的方法，以及通过使用通过所述筛选方法获得的物质来治疗消化系统中的癌症的方法。

公开(公告)号：EP1316608A1

公开(公告)日：2003-06-04

申请号：EP01963410.4

申请日：2001-08-31

申请人： KYOWA HAKKO KOGYO CO., LTD.

发明人： NARIMATSU, Hisashi ,  SASAKI, Katsutoshi c/o Tokyo Research Laboratories ,  NATSUME, Ayumi c/o Tokyo Research Laboratories ,  MIO, Hiroyuki c/o Kyowa Hakko Kogyo Co., Ltd. ,  NAKAGAWA, Satoshi ,  SEKINE, Susumu c/o Tokyo Research Laboratories ,  TOGAYACHI, Akira

IPC分类号： C12N15/54 ,  C12N9/10 ,  C12Q1/68 ,  C12N5/16 ,  C12N5/14 ,  C12N1/11 ,  C12P19/28 ,  C07K16/40

CPC分类号： C12N9/1051 ,  A01K2217/05 ,  A01K2217/075 ,  C07K2319/00 ,  C12N9/1241 ,  C12N2799/026 ,  C12Y204/0108

摘要： The present invention provides a novel polypeptide having a β1, 3-N-acetylglucosaminyltransferase activity, an agent for synthesizing a sugar chain comprising the polypeptide, a process for producing a sugar chain or a complex carbohydrate using the agent for synthesizing a sugar chain, DNA encoding the polypeptide, a process for producing the polypeptide, an antibody against the polypeptide, and a diagnosis method and a medicament for treatment for inflammation, cancer or tumor metastasis using the DNA or the antibody. The present invention is useful for synthesis of a useful sugar chain and diagnosis and treatment for inflammatory diseases, cancer or tumor metastasis.

摘要翻译： 本发明提供一种具有β1,3-N-乙酰氨基葡糖基转移酶活性的新型多肽，用于合成包含该多肽的糖链的试剂，使用该糖合成试剂制备糖链或复合碳水化合物的方法， 编码多肽的DNA，产生多肽的方法，针对多肽的抗体，以及诊断方法和用于使用DNA或抗体治疗炎症，癌症或肿瘤转移的药物。 本发明可用于合成有用的糖链，并用于炎性疾病，癌症或肿瘤转移的诊断和治疗。