公开(公告)号：EP1162269A1

公开(公告)日：2001-12-12

申请号：EP00905320.8

申请日：2000-02-24

申请人： KYOWA HAKKO KOGYO CO., LTD.

发明人： NARIMATSU, Hisashi ,  ISSHIKI, Soichiro ,  TOGAYACHI, Akira ,  SASAKI, Katsutoshi, Tokyo Research Laboratories

IPC分类号： C12N15/54 ,  C12P21/02 ,  C12N9/10 ,  C12N1/21 ,  C12N5/14 ,  C12N5/16 ,  C12Q1/68 ,  C12N15/63 ,  A01K67/027 ,  G01N33/15 ,  G01N33/50 ,  G01N33/574 ,  A01H5/00

CPC分类号： C12N9/1051 ,  A61K38/00 ,  A61K39/00 ,  C12P19/04

摘要： According to the present invention, there can be provided a novel polypeptide having β1,3-galactosyltransferase activity involved in the synthesis of type 1 sugar chains, a DNA coding for said polypeptide, a recombinant vector comprising said DNA, a transformant carrying said recombinant vector, a process for producing type 1 sugar chain-containing sugar chains and complex carbohydrates by use of said polypeptide or said transformant, an antibody recognizing said polypeptide, a method for detecting or quantifying said polypeptide by use of said antibody, a method for screening a substance correlated with said polypeptide, a method for diagnosis or treatment of cancers in the digestive system by use of said DNA or said antibody, and a method for treatment of cancers in the digestive system by use of a substance obtained by said screening method.

摘要翻译： 根据本发明，可以提供一种参与合成1型糖链的β1,3-半乳糖基转移酶活性的新型多肽，编码所述多肽的DNA，包含所述DNA的重组载体，携带所述重组体的转化体 载体，通过使用所述多肽或所述转化体产生含1糖链的糖链和复合碳水化合物的方法，识别所述多​​肽的抗体，通过使用所述抗体检测或定量所述多肽的方法，筛选方法 与所述多肽相关的物质，通过使用所述DNA或所述抗体在消化系统中诊断或治疗癌症的方法，以及通过使用通过所述筛选方法获得的物质来治疗消化系统中的癌症的方法。