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21 条记录 (耗时 0.017 秒)

    IMPROVED RADIATION THERAPY PLANNING PROCEDURE
    3.
    发明公开
    IMPROVED RADIATION THERAPY PLANNING PROCEDURE 审中-公开
    方法改良的放射治疗计划

    公开(公告)号：EP1981593A2

    公开(公告)日：2008-10-22

    申请号：EP07700651.8

    申请日：2007-01-22

    申请人： Philips Intellectual Property & Standards GmbH ,  Koninklijke Philips Electronics N.V.

    发明人： SPIES, Lothar ,  HUMMEL, Helga ,  RIBBING, Carolina ,  HOFFMANN, Ralf ,  BACHMANN, Peter Klaus

    IPC分类号： A61N5/10

    CPC分类号： A61N5/1031

    摘要： An improved radiation therapy planning procedure is suggested. The procedure comprises the steps of specifying and determining the absolute grade of cell degeneracy by in-vitro tests, whereby marker(s) indicative for specific cell degeneracy are detected and quantified, establishing a biology-based segmentation of areas with similar grade of relative cell degeneracy and applying the absolute grade of cell degeneracy to the biology-based segmentation data, thereby establishing an improved radiation therapy planning procedure. Moreover, the present invention suggests a system for an improved radiation therapy planning procedure and its use in procedures of diagnosis and/or therapy management of cancer.

    COMPOUNDS AND METHODS FOR THE LABELING AND AFFINITY-SELECTION OF PROTEINS
    6.
    发明公开
    COMPOUNDS AND METHODS FOR THE LABELING AND AFFINITY-SELECTION OF PROTEINS 审中-公开
    连接和方法蛋白质的鉴定和亲和力选择

    公开(公告)号：EP2274621A2

    公开(公告)日：2011-01-19

    申请号：EP09730039.6

    申请日：2009-04-02

    申请人： Koninklijke Philips Electronics N.V.

    发明人： HOFFMANN, Ralf ,  ROMIJN, Edwin, P. ,  DIRKSEN, Eef, H. C.

    IPC分类号： G01N33/68 ,  C07K1/13

    CPC分类号： C07K1/13 ,  C12Q2563/167 ,  C40B20/04 ,  C40B70/00 ,  G01N33/58 ,  G01N33/6848 ,  G01N2458/15

    摘要： The present invention relates to kits and methods for the isotopic/isobaric labeling and the subsequent affinity selection and analysis of proteinaceous molecules. In particular, the invention relates to a kit-of-parts comprising a combinatorial plurality of labeling reagent for the labeling of proteinaceous molecules, each labeling reagent comprising an isobaric label component, an isotopic label component, and a reactive group capable of reacting with a proteinaceous molecule, wherein the isotopic label component concomitantly is an affinity tag. The invention is also directed to a corresponding method for the analysis of proteinaceous molecules, comprising labeling at least one subset of the proteinaceous molecules present by employing a kit-of-parts as defined herein and subsequently separating the labeled molecules by affinity purification via the affinity tag comprised in the label. Finally, the invention relates to the uses of such methods for protein expression profiling or proteomic analyses.

    SELECTIVE ENRICHMENT OF POST-TRANSLATIONALLY MODIFIED PROTEINS AND/OR PEPTIDES FROM COMPLEX SAMPLES
    7.
    发明公开
    SELECTIVE ENRICHMENT OF POST-TRANSLATIONALLY MODIFIED PROTEINS AND/OR PEPTIDES FROM COMPLEX SAMPLES 审中-公开
    蛋白选择性富集翻译后修饰和/或从复杂样品肽

    公开(公告)号：EP2225260A1

    公开(公告)日：2010-09-08

    申请号：EP08854605.6

    申请日：2008-11-17

    申请人： Koninklijke Philips Electronics N.V.

    发明人： HOFFMANN, Ralf ,  VISSER, Hugo, M. ,  ROMIJN, Edwin, P.

    IPC分类号： C07K1/14

    CPC分类号： C07K1/14

    摘要： The present invention relates to the selective enrichment of post- translationally modified proteins and/or peptides from complex samples by combining a particular protein/peptide labeling and fractionation strategy with specific chemical and/or enzymatic reactions targeting the post-translational modification to be analyzed. More specifically, the invention relates to methods for the enrichment and/or separation of phospho-proteins and/or -peptides, and particularly for the discrimination between different subsets of phospho-proteins and/or -peptides in complex samples.

    METHODS FOR ANALYSING PROTEIN SAMPLES BASED ON THE IDENTIFICATION OF C-TERMINAL PEPTIDES
    9.
    发明公开
    METHODS FOR ANALYSING PROTEIN SAMPLES BASED ON THE IDENTIFICATION OF C-TERMINAL PEPTIDES 审中-公开
    法分析的基础上C-ENDPEPTIDEN鉴定中的蛋白质样品

    公开(公告)号：EP2069797A2

    公开(公告)日：2009-06-17

    申请号：EP07826241.7

    申请日：2007-09-03

    申请人： Koninklijke Philips Electronics N.V.

    发明人： HOFFMANN, Ralf

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6848

    摘要： The present invention relates to a method for identifying proteins in one or more samples based on the isolation and analysis of their C-terminal peptides. The isolated peptides are purified and analysed by Mass spectroscopy. Identification of the parent protein is based on the mass of the C-terminal peptide in combination with additional physicochemical parameters. The present invention further relates to an annotated database of C-terminal peptides of in silico cleaved proteins comprising the masses of C-terminal peptides and one or more physicochemical properties thereof.

    PHOSPHODIESTERASE 4D7 AS MARKER FOR MALIGNANT, HORMONE-SENSITIVE PROSTATE CANCER
    10.
    发明公开
    PHOSPHODIESTERASE 4D7 AS MARKER FOR MALIGNANT, HORMONE-SENSITIVE PROSTATE CANCER 审中-公开
    PHOSPHODIESTERASE 4D7 ALS KREBSMARKER

    公开(公告)号：EP2430190A1

    公开(公告)日：2012-03-21

    申请号：EP10726250.3

    申请日：2010-05-11

    申请人： Koninklijke Philips Electronics N.V. ,  University Court Of The University Of Glasgow

    发明人： HOFFMANN, Ralf ,  HOUSLAY, Miles, D. ,  HENDERSON, David, J. P.

    IPC分类号： C12Q1/68 ,  G01N33/574 ,  C12N9/16 ,  C12Q1/44 ,  C12N15/11

    CPC分类号： C12Q1/6886 ,  C12N9/16 ,  C12N15/1137 ,  C12N15/115 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/16 ,  C12Q1/44 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Y301/04017 ,  G01N33/57434 ,  G01N2800/52

    摘要： The present invention relates to phosphodiesterase 4D7 (PDE4D7) for use as a marker for malignant, hormone-sensitive prostate cancer, wherein the expression of the marker is increased when comparing the expression in malignant, hormone-sensitive prostate cancer tissue, to the expression in normal tissue or benign prostate tumor tissue, and the use of PDE4D7 as a diagnostic marker for malignant, hormone-sensitive prostate cancer. The present invention also relates to a composition for diagnosing, detecting, monitoring or prognosticating malignant, hormone-sensitive prostate cancer, a corresponding detection method, a method allowing to discriminate between a benign and malignant hormone-sensitive prostate cancer and a method of data acquisition, as well as corresponding immunoassays. The present invention also relates to a method of identifying an individual for eligibility for malignant, hormone-sensitive prostate cancer as well as an immunoassay for stratifying an individual with such prostate cancer. The present invention further envisages pharmaceutical compositions and their use for the treatment of malignant, hormone-sensitive prostate cancer.

    摘要翻译： 本发明涉及用作恶性，激素敏感性前列腺癌的标志物的磷酸二酯酶4D7（PDE4D7），其中当将恶性，激素敏感性前列腺癌组织中的表达与恶性，激素敏感性前列腺癌组织中的表达比较时，标志物的表达增加 正常组织或良性前列腺肿瘤组织，以及使用PDE4D7作为恶性，激素敏感性前列腺癌的诊断标志物。 本发明还涉及用于诊断，检测，监测或预测恶性，激素敏感性前列腺癌的组合物，相应的检测方法，允许区分良性和恶性激素敏感性前列腺癌的方法和数据采集方法 ，以及相应的免疫测定。 本发明还涉及鉴定个体对恶性，激素敏感性前列腺癌的资格的方法以及用这种前列腺癌分层个体的免疫测定法。 本发明进一步设想药物组合物及其用于治疗恶性，激素敏感性前列腺癌的用途。