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公开(公告)号：EP2932268A1
公开(公告)日：2015-10-21
申请号：EP13865771.3
申请日：2013-12-17
申请人： Leukodx Ltd
发明人： KASDAN, Harvey, Lee , MEISSONNIER, Julien , ZUTA, Yoav , ROSEN, Micha , HIMMEL, Yael , BRODER, Yehoshua , DAVIS, Bruce , GOLDMAN, Bruce , GIRON, Boaz , BOTESAZAN, Zion , BLASBERG, Eliezer , SEMMEL, Ilan , ASCHKENASY, Jacques
IPC分类号： G01N33/53 , G01N21/75 , C12M1/34 , G01N33/558
CPC分类号： G01N33/5302 , B01L3/502 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/025 , B01L2200/10 , B01L2300/041 , B01L2300/0654 , B01L2300/0816 , B01L2300/0867 , B01L2300/0877 , B01L2300/0883 , B01L2300/123 , B01L2300/18 , B01L2400/0406 , B01L2400/0481 , G01N15/1459 , G01N15/1484 , G01N21/03 , G01N21/6428 , G01N21/75 , G01N33/5091 , G01N33/54386 , G01N33/569 , G01N33/56972 , G01N33/582 , G01N33/68 , G01N33/6872 , G01N2015/1006 , G01N2021/0328 , G01N2021/6439 , G01N2021/6482 , G01N2035/00158 , G01N2333/70535 , G01N2333/70596 , G01N2800/26
摘要： The present invention provides self-contained systems, apparatus and methods for determining a chemical state, the system includes a stationary cartridge for performing the assay therein, the cartridge adapted to house at least one reagent adapted to react with a sample; and at least one reporter functionality adapted to report a reaction of the at least one reagent with the sample to report a result of the assay, a mechanical controller including a first urging means adapted to apply a force externally onto the cartridge to release the at least one reagent; and at least one second urging means adapted to apply a removable force to induce fluidic movement in a first direction in the cartridge and upon removal of the force causing fluidic movement in an opposite direction to the first direction, an optical reader adapted to detect the reaction and a processor adapted to receive data from the optical reader and to process the data to determine said chemical state.
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公开(公告)号：EP2558870B1
公开(公告)日：2017-06-07
申请号：EP11768557.8
申请日：2011-04-11
申请人： Leukodx Ltd
发明人： KASDAN, Harvey, Lee , RAJUAN, Menashe , BRODER, Yehoshua , MEISSONNIER, Julien , DAVIS, Bruce , ZUTA, Yoav
CPC分类号： G01N21/6486 , G01N21/6428 , G01N33/5094 , G01N35/00 , G01N2021/6423
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公开(公告)号：EP2932266A1
公开(公告)日：2015-10-21
申请号：EP13864008.1
申请日：2013-12-17
申请人： Leukodx Ltd
发明人： KASDAN, Harvey, Lee , MEISSONNIER, Julien , ZUTA, Yoav , ROSEN, Micha , HIMMEL, Yael , BRODER, Yehoshua , DAVIS, Bruce , GOLDMAN, Bruce , GIRON, Boaz , BOTESAZAN, Zion , BLASBERG, Eliezer , SEMMEL, Ilan , ASCHKENASY, Jacques
IPC分类号： G01N33/50 , G01N33/53 , G01N33/558 , G01N21/75 , C12M1/34
CPC分类号： G01N33/5302 , B01L3/502 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/025 , B01L2200/10 , B01L2300/041 , B01L2300/0654 , B01L2300/0816 , B01L2300/0867 , B01L2300/0877 , B01L2300/0883 , B01L2300/123 , B01L2300/18 , B01L2400/0406 , B01L2400/0481 , G01N15/1459 , G01N15/1484 , G01N21/03 , G01N21/6428 , G01N21/75 , G01N33/5091 , G01N33/54386 , G01N33/569 , G01N33/56972 , G01N33/582 , G01N33/68 , G01N33/6872 , G01N2015/1006 , G01N2021/0328 , G01N2021/6439 , G01N2021/6482 , G01N2035/00158 , G01N2333/70535 , G01N2333/70596 , G01N2800/26
摘要： The present invention provides self-contained systems, apparatus and methods for determining a chemical state, the system includes a stationary cartridge for performing the assay therein, the cartridge adapted to house at least one reagent adapted to react with a sample; and at least one reporter functionality adapted to report a reaction of the at least one reagent with the sample to report a result of the assay, a mechanical controller including a first urging means adapted to apply a force externally onto the cartridge to release the at least one reagent; and at least one second urging means adapted to apply a removable force to induce fluidic movement in a first direction in the cartridge and upon removal of the force causing fluidic movement in an opposite direction to the first direction, an optical reader adapted to detect the reaction and a processor adapted to receive data from the optical reader and to process the data to determine said chemical state.
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公开(公告)号：EP2558870A2
公开(公告)日：2013-02-20
申请号：EP11768557.8
申请日：2011-04-11
申请人： Leukodx Ltd
发明人： KASDAN, Harvey, Lee , RAJUAN, Menashe , BRODER, Yehoshua , MEISSONNIER, Julien , DAVIS, Bruce , ZUTA, Yoav
CPC分类号： G01N21/6486 , G01N21/6428 , G01N33/5094 , G01N35/00 , G01N2021/6423
摘要： Provided is a system and method for determination of a medical condition, the system including a disposable cartridge adapted to receive a volume of a body fluid, the cartridge comprising a plurality of sections, at least one of the sections adapted to react at least one reactant with the bodily fluid to form a pretreated sample; and an optics unit comprising at least one excitation illumination adapted to convey radiation to the pre-treated sample, at least one multi-spectral emission detector and at least one of a photon counter and an integrator, wherein the at least one excitation illumination and the at least one multi-spectral emission detector are disposed on the same side of the cartridge; and wherein the optics unit is adapted to detect a plurality of spectrally distinct signals generated by interaction of the radiation and the pre-treated sample in the cartridge, thereby determining said medical condition.
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公开(公告)号：EP3462172A1
公开(公告)日：2019-04-03
申请号：EP18194844.9
申请日：2013-12-17
申请人： Leukodx Ltd
发明人： KASDAN, Harvey, Lee , MEISSONNIER, Julien , ZUTA, Yoav , ROSEN, Micha , HIMMEL, Yael , BRODER, Yehoshua , DAVIS, Bruce , GOLDMAN, Bruce , GIRON, Boaz , BOTESAZAN, Zion , BLASBERG, Eliezer , SEMMEL, Ilan , ASCHKENASY, Jacques
IPC分类号： G01N33/53 , G01N21/75 , C12M1/34 , G01N33/558 , B01L3/00 , G01N21/64 , G01N33/569 , G01N21/03
摘要： The present invention provides self-contained systems, apparatus and methods for determining a chemical state, the system includes a stationary cartridge for performing the assay therein, the cartridge adapted to house at least one reagent adapted to react with a sample; and at least one reporter functionality adapted to report a reaction of the at least one reagent with the sample to report a result of the assay, a mechanical controller including a first urging means adapted to apply a force externally onto the cartridge to release the at least one reagent; and at least one second urging means adapted to apply a removable force to induce fluidic movement in a first direction in the cartridge and upon removal of the force causing fluidic movement in an opposite direction to the first direction, an optical reader adapted to detect the reaction and a processor adapted to receive data from the optical reader and to process the data to determine said chemical state.
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公开(公告)号：EP3239717A1
公开(公告)日：2017-11-01
申请号：EP17173498.1
申请日：2011-04-11
申请人： Leukodx Ltd
发明人： KASDAN, Harvey Lee , RAJUAN, Menashe , BRODER, Yehoshua , MEISSONNIER, Julien , DAVIS, Bruce , ZUTA, Yoav
摘要： The present invention provides a system and method for determination of a medical condition, the system including a disposable cartridge adapted to receive a volume of a body fluid, the cartridge comprising a plurality of sections, at least one of the sections adapted to react at least one reactant with the bodily fluid to form a pre-treated sample; and an optics unit comprising at least one excitation illumination adapted to convey radiation to the pre-treated sample, at least one multi-spectral emission detector and at least one of a photon counter and an integrator, wherein the at least one excitation illumination and the at least one multi-spectral emission detector are disposed on the same side of the cartridge; and wherein the optics unit is adapted to detect a plurality of spectrally distinct signals generated by interaction of the radiation and the pre-treated sample in the cartridge, thereby determining said medical condition.
摘要翻译： 本发明提供了一种用于确定医疗状况的系统和方法，所述系统包括适于接收一定体积的体液的一次性药筒，所述药筒包括多个区段，所述区段中的至少一个适于至少反应 一种反应物与体液混合以形成预处理的样品; 以及光学单元，其包括适于将辐射传送到预处理样本的至少一个激发照明，至少一个多光谱发射检测器以及光子计数器和积分器中的至少一个，其中所述至少一个激发照明和 至少一个多光谱发射检测器设置在盒的相同侧上; 并且其中所述光学单元适于检测由所述辐射和所述盒中的所述预处理样品的相互作用产生的多个光谱不同的信号，由此确定所述医疗状况。
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