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公开(公告)号：EP2461869A1
公开(公告)日：2012-06-13
申请号：EP10739442.1
申请日：2010-07-28
申请人： Merck Patent GmbH
发明人： CHEN, Xiaoling , KARRA, Srinivasa R. , HUCK, Bayard R. , LAN, Ruoxi , SUTTON, Amanda E. , GOUTOPOULOS, Andreas , HODOUS, Brian L. , JONES, Reinaldo C.
IPC分类号： A61P35/00 , A61K31/519 , C07D471/04 , C07D498/14
CPC分类号： C07D471/04 , C07D498/14
摘要： The invention provides novel substituted azaheterocyclic compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
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公开(公告)号：EP2396307B1
公开(公告)日：2014-10-15
申请号：EP10705453.8
申请日：2010-02-04
申请人： Merck Patent GmbH
发明人： SUTTON, Amanda E. , RICHARDSON, Thomas E. , HUCK, Bayard R. , KARRA, Srinivasa R. , CHEN, Xiaoling , XIAO, Yufang , GOUTOPOULOS, Andreas , LAN, Ruoxi , PERREY, David , VANDEVEER, Harold, George , LIU-BUJALSKI, Lesley , STIEBER, Frank , HODOUS, Brian L. , QIU, Hui , JONES, Reinaldo C. , HEASLEY, Brian
IPC分类号： C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , A61K31/517 , A61P35/00
CPC分类号： C07D215/04 , A61K31/47 , C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04
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3.发明公开COMPOSITIONS AND METHODS FOR THE PRODUCTION OF PYRIMIDINE AND PYRIDINE COMPOUNDS WITH BTK INHIBITORY ACTIVITY 审中-公开组合物和方法嘧啶的制备用吡啶BTK锁定效果
公开(公告)号：EP2718270A2
公开(公告)日：2014-04-16
申请号：EP12728011.3
申请日：2012-06-10
申请人： Merck Patent GmbH
发明人： HODOUS, Brian L. , LIU-BUJALSKI, Lesley , JONES, Reinaldo , BANKSTON, Donald , JOHNSON, Theresa L. , MOCHALKIN, Igor , NGUYEN, Ngan , QIU, Hui , GOUTOPOULOS, Andreas , BRUGGER, Nadia
IPC分类号： C07D239/47 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/12 , C07D213/68 , C07D213/73 , C07D213/74 , C07D413/14 , C07D495/04 , A61K31/506 , A61K31/513 , A61K31/505 , A61K31/5377 , A61K31/4418 , A61P35/00 , A61P35/02
CPC分类号： A61K31/69 , A61K31/44 , A61K31/4545 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/55 , C07D213/68 , C07D213/73 , C07D213/74 , C07D239/47 , C07D239/48 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D451/02 , C07D471/10 , C07D495/04 , C07F5/022
摘要： The present invention provides novel pyrimidine and pyridine compounds according to Formula (I), Formula (II), Formula (III), Formula (IV) and Formula (V) their manufacture and use for the treatment of hyperproliferative diseases including, but not limited to, cancer, lupus, allergic disorders, Sjogren's disease and rheumatoid arthritis. In preferred embodiments, the present invention describes irreversible kinase inhibitors including, but not limited to, inhibitors of Bruton's tyrosine kinase.
摘要翻译： 本发明提供了新的嘧啶并吡啶化合物雅丁式（I），式（II），式（III），式（IV）和式（V）它们的制造和使用的过度增殖性疾病，包括治疗，但不限 癌症，红斑狼疮，过敏性疾病，干燥综合征和类风湿性关节炎。 在优选的实施方案中，本发明描述的不可逆的激酶抑制剂，包括但不限于，布鲁顿酪氨酸激酶的抑制剂。
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公开(公告)号：EP2396307A1
公开(公告)日：2011-12-21
申请号：EP10705453.8
申请日：2010-02-04
申请人： Merck Patent GmbH
发明人： SUTTON, Amanda E. , RICHARDSON, Thomas E. , HUCK, Bayard R. , KARRA, Srinivasa R. , CHEN, Xiaoling , XIAO, Yufang , GOUTOPOULOS, Andreas , LAN, Ruoxi , PERREY, David , VANDEVEER, Harold, George , LIU-BUJALSKI, Lesley , STIEBER, Frank , HODOUS, Brian L. , QIU, Hui , JONES, Reinaldo C. , HEASLEY, Brian
IPC分类号： C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , A61K31/517 , A61P35/00
CPC分类号： C07D215/04 , A61K31/47 , C07D239/94 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04
摘要： The invention provides novel substituted amino azaheterocyclic carboxamide compounds according to Formula (I), their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
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公开(公告)号：EP2461869B1
公开(公告)日：2013-08-21
申请号：EP10739442.1
申请日：2010-07-28
申请人： Merck Patent GmbH
发明人： CHEN, Xiaoling , KARRA, Srinivasa R. , HUCK, Bayard R. , LAN, Ruoxi , SUTTON, Amanda E. , GOUTOPOULOS, Andreas , HODOUS, Brian L. , JONES, Reinaldo C.
IPC分类号： A61P35/00 , A61K31/519 , C07D471/04 , C07D498/14
CPC分类号： C07D471/04 , C07D498/14
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