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公开(公告)号：EP2953614A1
公开(公告)日：2015-12-16
申请号：EP14705554.5
申请日：2014-02-04
申请人： Midatech Ltd.
CPC分类号： A61K47/48861 , A61K9/143 , A61K9/145 , A61K9/5115 , A61K47/549 , A61K47/6923 , B82Y5/00
摘要： Nanoparticles having a core and a corona of ligands covalently linked to the core, wherein an active agent and a permeation enhancer are bound to or associated with the nanoparticles.
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2.发明公开
公开(公告)号：EP2717858A1
公开(公告)日：2014-04-16
申请号：EP12796229.8
申请日：2012-06-08
申请人： MonoSol Rx, LLC , Midatech Ltd.
IPC分类号： A61K9/14
CPC分类号： A61K9/0019 , A61K9/19 , A61K9/5094 , A61K9/7007 , A61K47/6923
摘要： The present invention is directed at compositions and products, and methods of making and administering such compositions and products, including for the treatment of mammals and particularly humans. Nanoparticles having a core and a corona of ligands covalentJy linked to the core, wherein differing species of peptides are bound to the nanoparticles and incorporated into various dosage forms.
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公开(公告)号：EP2717858B1
公开(公告)日：2018-08-08
申请号：EP12796229.8
申请日：2012-06-08
CPC分类号： A61K9/0019 , A61K9/19 , A61K9/5094 , A61K9/7007 , A61K47/6923
摘要： The present invention is directed at compositions and products, and methods of making and administering such compositions and products, including for the treatment of mammals and particularly humans. Nanoparticles having a core and a corona of ligands covalentJy linked to the core, wherein differing species of peptides are bound to the nanoparticles and incorporated into various dosage forms.
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公开(公告)号：EP2579898A1
公开(公告)日：2013-04-17
申请号：EP11728365.5
申请日：2011-06-10
申请人： Midatech Ltd.
发明人： RADEMACHER, Thomas , WILLIAMS, Phillip , BACHMANN, Christof , BARRIENTOS, Africa, Garcia , DOMINGUEZ, Ester de Torres , MENOYO, Javier del Campo
CPC分类号： A61K47/6923
摘要： Nanoparticles having a core and a corona of ligands covalently linked to the core, wherein peptides are bound to or associated with the nanoparticles.
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公开(公告)号：EP3237016A1
公开(公告)日：2017-11-01
申请号：EP15820158.2
申请日：2015-12-22
申请人： Midatech Ltd
发明人： GOLDING, Jon , WILLIAMS, Phillip , ROSKAMP, Meike
CPC分类号： A61K33/24 , A61K9/0014 , A61K47/549 , A61K47/6923 , A61K47/6929 , A61N5/10 , A61N2005/1098
摘要： The present invention provides a nanoparticle comprising a core comprising a metal; and a corona comprising a plurality of ligands covalently linked to the core, the plurality of ligands including at least a first species of ligand comprising an ethylene glycol portion and an amine group and at least a second species of ligand comprising a carbohydrate group, for use in a method of treating a cancer, particularly skin cancer, in a mammalian subject. Also disclosed are methods of treatment by administering the nanoparticles alone or in combination with radiotherapy.
摘要翻译： 本发明提供了包含含有金属的核的纳米颗粒; 以及包含共价连接至所述核的多个配体的电晕，所述多个配体包括至少第一种包含乙二醇部分和胺基的配体和至少第二种包含碳水化合物基团的配体种类以供使用 在哺乳动物对象中治疗癌症，特别是皮肤癌的方法中。 还公开了通过单独施用纳米颗粒或与放疗组合施用的治疗方法。
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公开(公告)号：EP2753360B1
公开(公告)日：2017-04-26
申请号：EP12756725.3
申请日：2012-09-07
申请人： Midatech Ltd
CPC分类号： C07K14/4748 , A61K38/38 , A61K39/0011 , A61K47/6923 , A61K47/6929 , A61K2039/55516 , A61K2039/572 , A61K2039/60 , A61K2039/627 , C07K7/06 , C07K7/08 , C07K14/77
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公开(公告)号：EP3217958B1
公开(公告)日：2020-02-26
申请号：EP15794158.4
申请日：2015-11-11
发明人： WILLIAMS, Phillip , GROVES, Rhian , PALMER, Daniel
IPC分类号： A61K31/495 , A61K31/4745 , A61K31/205 , A61K31/282 , A61K31/704 , A61K31/337 , A61K38/17 , A61K9/00 , A61K9/16 , A61K9/51 , A61K47/34 , A61K47/50 , A61P5/00 , A61P25/00 , A61P27/02
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公开(公告)号：EP2579898B1
公开(公告)日：2019-01-09
申请号：EP11728365.5
申请日：2011-06-10
申请人： Midatech Ltd.
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公开(公告)号：EP3217958A1
公开(公告)日：2017-09-20
申请号：EP15794158.4
申请日：2015-11-11
发明人： WILLIAMS, Phillip , GROVES, Rhian , PALMER, Daniel
摘要： The present invention provides a microparticle comprising at least one biocompatible polymer, the microparticle encapsulating at least one nanoparticle, the nanoparticle comprising: (i) a core comprising a metal and/or a semiconductor; and (ii) a corona comprising a plurality of ligands covalently linked to the core, wherein said ligands comprise at least one carbohydrate and/or glutathione. The nanoparticle may additionally comprise a biologically active agent or detectable label covalently linked or non-covalently bound to said corona and/or said core. Also disclosed are pharmaceutical compositions comprising the microparticles, processes for their production and uses of the microparticles in methods of therapy.
摘要翻译： 本发明提供包含至少一种生物相容性聚合物的微粒，所述微粒包封至少一个纳米粒子，所述纳米粒子包含：（i）包含金属和/或半导体的核; 和（ii）包含多个共价连接至核的配体的冠，其中所述配体包含至少一种碳水化合物和/或谷胱甘肽。 纳米颗粒可另外包含与所述电晕和/或所述核共价连接或非共价结合的生物活性剂或可检测标记。 还公开了包含微粒的药物组合物，其制备方法和微粒在治疗方法中的用途。
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公开(公告)号：EP2964263A1
公开(公告)日：2016-01-13
申请号：EP14705556.0
申请日：2014-02-06
申请人： Midatech Ltd.
CPC分类号： A61K9/146 , A61K38/29 , A61K47/6923 , A61K47/6929
摘要： The present invention relates to teriparatide peptide-carrying nanoparticles, particularly for use in medicine, and includes methods for treatment of disorders, e.g., of bone density. Nanoparticle composition comprise a nanoparticle comprising a core comprising a metal and/or a semiconductor; and a corona comprising a plurality of ligands covalently linked to the core, wherein said plurality of ligands comprise at least one glutathione; and at least one teriparatide peptide that is non-covalently bound to the corona.
摘要翻译： 本发明涉及携带特立帕肽的纳米颗粒，特别用于医学，并且包括用于治疗例如骨密度病症的方法。 纳米颗粒组合物包含纳米颗粒，所述纳米颗粒包含含有金属和/或半导体的核心; 以及包含共价连接至所述核的多个配体的冠，其中所述多个配体包含至少一个谷胱甘肽; 和至少一种非共价结合于冠的特立帕肽。
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