公开(公告)号：EP2953614A1

公开(公告)日：2015-12-16

申请号：EP14705554.5

申请日：2014-02-04

申请人： Midatech Ltd.

发明人： WILLIAMS, Phillip ,  RADEMACHER, Thomas

IPC分类号： A61K9/14 ,  A61K47/48 ,  B82Y5/00 ,  A61K9/51

CPC分类号： A61K47/48861 ,  A61K9/143 ,  A61K9/145 ,  A61K9/5115 ,  A61K47/549 ,  A61K47/6923 ,  B82Y5/00

摘要： Nanoparticles having a core and a corona of ligands covalently linked to the core, wherein an active agent and a permeation enhancer are bound to or associated with the nanoparticles.

公开(公告)号：EP2717858A1

公开(公告)日：2014-04-16

申请号：EP12796229.8

申请日：2012-06-08

申请人： MonoSol Rx, LLC ,  Midatech Ltd.

发明人： WILLIAMS, Phillip ,  RADEMACHER, Thomas ,  SCHOBEL, Alexander, Mark ,  DADEY, Eric

IPC分类号： A61K9/14

CPC分类号： A61K9/0019 ,  A61K9/19 ,  A61K9/5094 ,  A61K9/7007 ,  A61K47/6923

摘要： The present invention is directed at compositions and products, and methods of making and administering such compositions and products, including for the treatment of mammals and particularly humans. Nanoparticles having a core and a corona of ligands covalentJy linked to the core, wherein differing species of peptides are bound to the nanoparticles and incorporated into various dosage forms.

公开(公告)号：EP2277548A3

公开(公告)日：2011-04-27

申请号：EP10009913.4

申请日：2004-06-07

申请人： CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS ,  Midatech Ltd.

发明人： Penades, S. ,  Martin-Lomas, M. ,  Martines De La Fuente, J.

IPC分类号： A61K47/48

CPC分类号： A61K47/48923 ,  A61K9/5094 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/1845 ,  A61K49/1881 ,  B82Y5/00 ,  Y10T428/2991

摘要： Materials and methods for making small magnetic particles, e.g. clusters of metal atoms, which can be employed as a substrate for immobilising a plurality of ligands. Also disclosed are uses of these magnetic nanoparticles as therapeutic and diagnostic reagents, and in the study of ligand-mediated interactions.

公开(公告)号：EP2956119B1

公开(公告)日：2019-08-14

申请号：EP14708315.8

申请日：2014-02-07

申请人： Midatech Ltd.

发明人： MALE, David K. ,  RADEMACHER, Thomas

IPC分类号： A61K9/51 ,  A61K47/50 ,  A61P25/00 ,  B82Y5/00

公开(公告)号：EP3419748A1

公开(公告)日：2019-01-02

申请号：EP17706504.2

申请日：2017-02-22

申请人： Midatech Ltd ,  Midatech Pharma (Wales) Limited

发明人： PALMER, Daniel ,  GROVES, Rhian ,  SEAMAN, Paul ,  CAVALIER-HIRTH, Victoria ,  PACE, Alessandro

IPC分类号： B01J13/02 ,  B01J13/04

公开(公告)号：EP2330208B1

公开(公告)日：2017-10-18

申请号：EP10181903.5

申请日：2005-05-24

申请人： Midatech Ltd.

发明人： Rademacher, Thomas William ,  Gumaa, Khalid ,  Martin-Lomas, Manuel ,  Penades, Soledad ,  Ojeda, Rafael ,  Barrientos, Africa

IPC分类号： A61K49/18 ,  A61K49/00 ,  A61K51/12 ,  C12N15/88 ,  A61K47/69 ,  G01N33/58

CPC分类号： A61K49/1857 ,  A61K49/0054 ,  A61K49/0065 ,  A61K51/1244 ,  B82Y5/00 ,  B82Y15/00 ,  C12N15/111 ,  C12N15/1138 ,  C12N2310/14 ,  C12N2310/351 ,  C12N2320/12

公开(公告)号：EP2029120B1

公开(公告)日：2011-07-27

申请号：EP07732419.2

申请日：2007-04-13

申请人： Midatech Ltd.

发明人： RADEMACHER, Thomas William ,  WILLIAMS, Philip

IPC分类号： A61K9/51 ,  A61K33/00 ,  A61K38/00 ,  A61K47/48

CPC分类号： A61K47/48092 ,  A61K33/24 ,  A61K39/385 ,  A61K47/549 ,  A61K47/6415 ,  A61K47/646 ,  A61K47/6923 ,  A61K47/6929 ,  A61K2039/55555 ,  A61K2039/6031 ,  B82Y5/00 ,  Y02A50/412

摘要： Nanoparticles for providing immune responses for the treatment or prophylaxis of infection by infectious agents such as viruses, parasites, bacteria, prions and fungi are described which comprises a core including metal and/or semiconductor atoms, wherein the core is covalently linked to a plurality of ligands, the ligands including a carbohydrate residue capable of stimulating an innate immune response, a T cell helper peptide and a danger signal. This platform may then be adapted by including one or more further ligands capable of producing a specific response to a target infectious agent.

公开(公告)号：EP3347055B1

公开(公告)日：2019-06-12

申请号：EP17715654.4

申请日：2017-03-29

申请人： Midatech Ltd.

发明人： COULTER, Tom ,  DAMMENT, Stephen ,  PACE, Alessandro ,  PALMER, Daniel

IPC分类号： A61K47/69 ,  A61K47/40

公开(公告)号：EP2717858B1

公开(公告)日：2018-08-08

申请号：EP12796229.8

申请日：2012-06-08

申请人： Aquestive Therapeutics, Inc. ,  Midatech Ltd.

发明人： WILLIAMS, Phillip ,  RADEMACHER, Thomas ,  SCHOBEL, Alexander, Mark ,  DADEY, Eric

IPC分类号： A61K9/14 ,  A61P3/10 ,  A61K9/00 ,  A61K9/19 ,  A61K9/50 ,  A61K9/70

CPC分类号： A61K9/0019 ,  A61K9/19 ,  A61K9/5094 ,  A61K9/7007 ,  A61K47/6923

摘要： The present invention is directed at compositions and products, and methods of making and administering such compositions and products, including for the treatment of mammals and particularly humans. Nanoparticles having a core and a corona of ligands covalentJy linked to the core, wherein differing species of peptides are bound to the nanoparticles and incorporated into various dosage forms.

公开(公告)号：EP3347055A1

公开(公告)日：2018-07-18

申请号：EP17715654.4

申请日：2017-03-29

申请人： Midatech Ltd.

发明人： COULTER, Tom ,  DAMMENT, Stephen ,  PACE, Alessandro ,  PALMER, Daniel

IPC分类号： A61K47/69 ,  A61K47/40

CPC分类号： A61K47/40 ,  A61K31/4045 ,  A61K47/6951 ,  C08B37/0015

摘要： The present invention provides a method for producing a cyclodextrin-panobinostat adduct, comprising: a) providing a first aqueous solution comprising a buffering agent, the solution having a pH in the range 2.0 to 4.0; b) dissolving panobinostat in said first aqueous solution to provide a second aqueous solution; and c) mixing said second aqueous solution comprising panobinostat with a third aqueous solution comprising a cyclodextrin to form a fourth aqueous solution comprising a cyclodextrin-panobinostat adduct. Also provided is an artificial cerebrospinal fluid (CSF) solution comprising the cyclodextrin-panobinostat adduct and medical uses of the cyclodextrin-panobinostat adduct, including in the treatment of brain tumours.