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公开(公告)号：EP1909912B1
公开(公告)日：2012-06-06
申请号：EP06762898.2
申请日：2006-07-28
发明人： MARTÍNEZ GIL, Ana , USÁN EGEA, Paola , MEDINA PADILLA, Miguel , GARCÍA PALOMERO, Esther , PÉREZ BAZ, Julia , FERNÁNDEZ CHIMENO, Rosa Isabel , FERNÁNDEZ MEDARDE, Antonio , CAÑEDO HERNÁNDEZ, Librada María , ROMERO MILLÁN, Francisco , CASTRO MORERA, Ana , ALONSO CASCÓN, Mercedes , SÁNCHEZ QUESADA, Jorge
IPC分类号： A61K31/444 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P3/10 , A61P39/06 , A61P9/04 , A61P9/10
CPC分类号： A61K31/44
摘要： The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment and/or prevention of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer´s Disease and Parkinson's Disease.
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2.发明公开USE OF COLLISMYCIN AND DERIVATIVES THEREOF AS OXIDATIVE STRESS INHIBITORS 有权使用collismycin A作为氧化应激的抑制剂
公开(公告)号：EP1909912A2
公开(公告)日：2008-04-16
申请号：EP06762898.2
申请日：2006-07-28
发明人： MARTÍNEZ GIL, Ana , USÁN EGEA, Paola , MEDINA PADILLA, Miguel , GARCÍA PALOMERO, Esther , PÉREZ BAZ, Julia , FERNÁNDEZ CHIMENO, Rosa Isabel , FERNÁNDEZ MEDARDE, Antonio , CAÑEDO HERNÁNDEZ, Librada María , ROMERO MILLÁN, Francisco , CASTRO MORENA, Ana , ALONSO CASCÓN, Mercedes , SÁNCHEZ QUESADA, Jorge
CPC分类号： A61K31/44
摘要： The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment and/or prevention of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer´s Disease and Parkinson's Disease.
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公开(公告)号：EP1758888B8
公开(公告)日：2010-04-07
申请号：EP05748329.9
申请日：2005-05-27
申请人： NOSCIRA, S.A.
发明人： MARTÍNEZ GIL, Ana , RUBIO ARRIETA, Laura , MUÑOZ RUÍZ, Pilar , DORRONSORO DÍAZ, Isabel , GARCÍA PALOMERO, Esther , DEL MONTE MILLÁN, María , MEDINA PADILLA, Miguel
IPC分类号： C07D401/12 , A61K31/454 , A61P25/28
CPC分类号： C07D401/12
摘要： The invention provides butyrylcholinesterase inhibitors of formula (I), which contain an heterocyclic moiety and a 4 piperidine moiety with a linker in between. The compounds show a very high activity and selectivity towards BuChE, making them useful for the treatment and/or prophylaxis of cognitive disorders and/or neurodegenerative disorders.
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4.发明公开N-PHENYL-PRENYLAMINE DERIVATIVES FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS 审中-公开的N- PHENYLPRENYLAMINDERIVATE认知，神经变性或神经元疾病的治疗或 疾病
公开(公告)号：EP2057114A1
公开(公告)日：2009-05-13
申请号：EP07788140.7
申请日：2007-08-01
申请人： NOSCIRA, S.A.
发明人： MARTÍNEZ GIL, Ana , CASTRO MORERA, Ana , MEDINA PADILLA, Miguel , MUÑOZ RUIZ, Pilar , LÓPEZ OGALLA, Javier , GARCÍA PALOMERO, Esther , DE AUSTRIA DE LUQUE, Celia , USÁN EGEA, Paola , VALENZUELA LIMIÑANA, Rita , GARCÍA FERNÁNDEZ, Pablo , DELGADO HERNÁNDEZ, Elena , PÉREZ FERNÁNDEZ, Daniel Ignacio
IPC分类号： C07C229/64 , C07C229/60 , C07C217/84 , C07C211/48 , C07C231/12 , C07C237/44 , C07C271/28 , C07C279/22 , C07D233/64 , C07D309/12 , C07D295/192 , A61K31/136 , A61K31/196 , A61K31/245 , A61K31/27
CPC分类号： C07C229/64 , C07C211/48 , C07C217/84 , C07C229/60 , C07C231/12 , C07C237/44 , C07C271/28 , C07C279/22 , C07D231/14 , C07D233/64 , C07D295/192 , C07D309/12
摘要： The present invention is related to a family of N-phenyl-prenylamine derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder.
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5.发明授权TRIPLE SUBSTITUTED PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES OR CONDITIONS, OR CANCER 有权TRIPLE取代邻菲罗啉用于治疗神经变性或血液疾病或 莱顿，或预防癌症
公开(公告)号：EP2373650B1
公开(公告)日：2012-10-24
申请号：EP09765124.4
申请日：2009-12-10
申请人： Noscira, S.A.
发明人： MEDINA PADILLA, Miguel , CASTRO MORERA, Ana , SÁNCHEZ-QUESADA, Jorge , GARCÍA PALOMERO, Esther , ALONSO CASCÓN, Mercedes. , HERRERO SANTOS, Susana. , VELA RUIZ, Marta. , USÁN EGEA, Paola. , RODRIGUEZ VILLANUEVA, Ana Luisa.
IPC分类号： C07D471/04 , A61K31/4745
CPC分类号： C07D471/04
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6.发明公开TRIPLE SUBSTITUTED PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES OR CONDITIONS, OR CANCER 有权TRIPLE取代邻菲罗啉用于治疗神经变性或血液疾病或 莱顿，或预防癌症
公开(公告)号：EP2373650A1
公开(公告)日：2011-10-12
申请号：EP09765124.4
申请日：2009-12-10
申请人： Noscira, S.A.
发明人： MEDINA PADILLA, Miguel , CASTRO MORERA, Ana , SÁNCHEZ-QUESADA, Jorge , GARCÍA PALOMERO, Esther , ALONSO CASCÓN, Mercedes. , HERRERO SANTOS, Susana. , VELA RUIZ, Marta. , USÁN EGEA, Paola. , RODRIGUEZ VILLANUEVA, Ana Luisa.
IPC分类号： C07D471/04 , A61K31/4745
CPC分类号： C07D471/04
摘要： The present invention relates to a new family of triple substituted phenantroline derivatives of formula (I), which are useful for the treatment or profilaxis of a neurodegenerative or haematological disease or condition or cancer, their use as a medicament, especially for treating a neurodegenerative or haematological disease or condition or cancer, and a pharmaceutical composition comprising the compounds.
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7.发明公开[1,10]-PHENANTHROLINE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE OR HAEMATOLOGICAL DISEASES 审中-公开[1,10]菲咯啉衍生物用于治疗神经变性疾病或血液学的治疗
公开(公告)号：EP2170464A2
公开(公告)日：2010-04-07
申请号：EP08760868.3
申请日：2008-06-11
申请人： NOSCIRA, S.A.
发明人： MARTÍNEZ GIL, Ana , CASTRO MORERA, Ana , MEDINA PADILLA, Miguel , SÁNCHEZ-QUESADA, Jorge , ALONSO CASCÓN, Mercedes , RUBIO ARRIETA, Laura , GARCÍA PALOMERO, Esther , USÁN EGEA, Paola
IPC分类号： A61P25/16 , A61P25/28 , A61P3/10 , A61K31/4745 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to a new family of [1,10]-phenantroline derivatives of formula (I), which are useful for the treatment or profilaxis of a neurodegenerative or haematological disease or condition, their use as a medicament, especially for treating a treatment neurodegenerative or haematological disease or condition, and a pharmaceutical composition comprising the compounds.
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8.发明公开PHENYL-PRENYL-ETHER DERIVATIVES FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS 审中-公开PHENYLPRENYLETHERDERIVATE认知，神经变性疾病或神经元疾病的治疗或 疾病
公开(公告)号：EP2051958A1
公开(公告)日：2009-04-29
申请号：EP07802460.1
申请日：2007-08-01
申请人： NOSCIRA, S.A.
发明人： MARTÍNEZ GIL, Ana , CASTRO MORERA, Ana , MEDINA PADILLA, Miguel , MUÑOZ RUIZ, Pilar , LÓPEZ OGALLA, Javier , RUBIO ARRIETA, Laura , GARCÍA PALOMERO, Esther , GARCÍA FERNÁNDEZ, Pablo , DE AUSTRIA DE LUQUE, Celia , DELGADO HERNÁNDEZ, Elena , USÁN EGEA, Paola , VALENZUELA LIMIÑANA, Rita
IPC分类号： C07C69/92 , C07C43/215 , C07C65/28 , C07C229/60 , C07C235/46 , C07C233/54 , A61K31/235 , A61P25/28
CPC分类号： C07C235/46 , C07C43/215 , C07C65/28 , C07C69/92 , C07C229/60 , C07C233/54
摘要： The present invention is related to a family of phenyl-prenyl-ether derivatives of formula (I), and to their use in the treatment of cognitive, neurodegenerative or neuronal diseases or disorders, such as Alzheimer's disease or 5 Parkinson's Disease. The present invention also relates to pharmaceutical compositions comprising the same. Further, the present invention is directed to the use of the compounds in the manufacture of a medicament for the treatment and/or prevention of a cognitive, neurodegenerative or neuronal disease or disorder.
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