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1.发明公开USE OF COLLISMYCIN AND DERIVATIVES THEREOF AS OXIDATIVE STRESS INHIBITORS 有权使用collismycin A作为氧化应激的抑制剂
公开(公告)号：EP1909912A2
公开(公告)日：2008-04-16
申请号：EP06762898.2
申请日：2006-07-28
发明人： MARTÍNEZ GIL, Ana , USÁN EGEA, Paola , MEDINA PADILLA, Miguel , GARCÍA PALOMERO, Esther , PÉREZ BAZ, Julia , FERNÁNDEZ CHIMENO, Rosa Isabel , FERNÁNDEZ MEDARDE, Antonio , CAÑEDO HERNÁNDEZ, Librada María , ROMERO MILLÁN, Francisco , CASTRO MORENA, Ana , ALONSO CASCÓN, Mercedes , SÁNCHEZ QUESADA, Jorge
CPC分类号： A61K31/44
摘要： The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment and/or prevention of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer´s Disease and Parkinson's Disease.
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公开(公告)号：EP1909912B1
公开(公告)日：2012-06-06
申请号：EP06762898.2
申请日：2006-07-28
发明人： MARTÍNEZ GIL, Ana , USÁN EGEA, Paola , MEDINA PADILLA, Miguel , GARCÍA PALOMERO, Esther , PÉREZ BAZ, Julia , FERNÁNDEZ CHIMENO, Rosa Isabel , FERNÁNDEZ MEDARDE, Antonio , CAÑEDO HERNÁNDEZ, Librada María , ROMERO MILLÁN, Francisco , CASTRO MORERA, Ana , ALONSO CASCÓN, Mercedes , SÁNCHEZ QUESADA, Jorge
IPC分类号： A61K31/444 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/28 , A61P3/10 , A61P39/06 , A61P9/04 , A61P9/10
CPC分类号： A61K31/44
摘要： The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment and/or prevention of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer´s Disease and Parkinson's Disease.
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3.发明授权DUAL BINDING SITE ACETYLCHOLINESTERASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权双重结合乙酰胆碱酯酶抑制剂用于治疗阿尔茨海默氏病的治疗
公开(公告)号：EP1558255B1
公开(公告)日：2006-12-27
申请号：EP03751019.5
申请日：2003-10-07
申请人： Neuropharma, S.A.
发明人： MARTINEZ GIL, Ana , DORRONSORO DIAZ, Isabel , RUBIO ARRIETA, Laura , ALONSO GORDILLO, Diana , FUERTES HUERTA, Ana , MORALES-ALCELAY, Susana , DEL MONTE MILLAN, Maria , GARCIA PALOMERO, Esther , USAN EGEA, Paola , DE AUSTRIA, Celia , MEDINA PADILLA, Miguel
IPC分类号： A61K31/473 , C07D219/12 , C07D401/12 , C07D417/12
CPC分类号： C07D401/12 , C07D219/12 , C07D417/12
摘要： A family of compounds of formula (I) wherein: X is one of the following radicals: (a), (b), (c) which behaves as dual site acetylcholinesterase inhibitors and which are especially useful for the treatment of cognitive disorders as senile dementia, cerebrovascular dementia, mild cognition impairment, attention deficit disorder, and/or neurodegenerative dementing disease with aberrant protein aggregations as specially Alzheimer’s disease, Parkinson disease, ALS, or prion diseases, as Creutzfeldt-Jakob disease or Gerstmann-Straussler-Scheinher disease.
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4.发明授权MARINE COMPOUNDS WITH CALCIUM CHANNEL BLOCKING PROPERTIES FOR THE TREATMENT OF COGNITIVE OR NEURODEGENERATIVE DISEASES 有权经过钙通道阻断性质的治疗认知或神经变性疾病CONNECTIONS海产
公开(公告)号：EP1761262B1
公开(公告)日：2008-12-03
申请号：EP05756055.9
申请日：2005-06-17
申请人： Neuropharma, S.A.
发明人： MARTÍNEZ GIL, Ana , ALONSO GORDILLO, Diana , DORRONSORO DÍAZ, Isabel , GARCÍA PALOMERO, Esther , DE AUSTRIA DE LUQUE, Celia , USÁN EGEA, Paola , DEL MONTE MILLÁN, María , MEDINA PADILLA, Miguel
IPC分类号： A61K31/42 , C07D261/20
CPC分类号： C07D261/20
摘要： The invention provides compounds having a spiro heterocyclic unit connected through a linker of a certain length to another spiro cycle, an imidazole ring or an amide group. Some of these compounds have been obtained from Aplysinia cavernicola and a mixture of Aplysina fulva and Oceanapia. The compounds exhibit VDCC blocker activity; some also show acetylcholinesterase and butyrylcholinesterase inhibition activities. Therefore they are useful in the treatment of cognitive and neurodegenerative disorders, such as brain ischemia, stroke, cognitive disorders as senile dementia, cerebrovascular dementia, mild recognition impairment, attention deficit disorder, and/or neurodegenerative dementing disease with aberrant protein aggregations as specially Alzheimers's disease or condition, or prion disease as Creutzfeld-Jakob disease or Gerstmann-Straussler-Scheinker disease.
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公开(公告)号：EP1976823A1
公开(公告)日：2008-10-08
申请号：EP06830653.9
申请日：2006-12-15
申请人： Neuropharma, S.A.
发明人： MARTÍNEZ GIL, Ana , CASTRO MORERA, Ana , MEDINA PADILLA, Miguel , MUÑOZ RUIZ, Pilar , RUBIO ARRIETA, Laura , GARCÍA PALOMERO, Esther , DE AUSTRIA DE LUQUE, Celia , SÁNCHEZ QUESADA, Jorge , PÉREZ FERNÁNDEZ, Daniel Ignacio , LÓPEZ OGALLA, Javier , ALONSO GORDILLO, Diana
IPC分类号： C07C235/60 , A61K31/166 , A61P25/28
CPC分类号： C07C235/60
摘要： The invention is directed to a compound of formula (I) Having VDCC blocking activity. These compounds are useful for the treatment of a series of human diseases and conditions, especially cognitive or neurodegenerative diseases or conditions.
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6.发明公开DUAL BINDING SITE ACETYLCHOLINESTERASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 有权双重结合乙酰胆碱酯酶抑制剂用于治疗阿尔茨海默氏病的治疗
公开(公告)号：EP1558255A2
公开(公告)日：2005-08-03
申请号：EP03751019.5
申请日：2003-10-07
申请人： Neuropharma, S.A.
发明人： MARTINEZ GIL, Ana , DORRONSORO DIAZ, Isabel , RUBIO ARRIETA, Laura , ALONSO GORDILLO, Diana , FUERTES HUERTA, Ana , MORALES-ALCELAY, Susana , DEL MONTE MILLAN, Maria , GARCIA PALOMERO, Esther , USAN EGEA, Paola , DE AUSTRIA, Celia , MEDINA PADILLA, Miguel
IPC分类号： A61K31/473 , C07D219/12 , C07D401/12 , C07D417/12
CPC分类号： C07D401/12 , C07D219/12 , C07D417/12
摘要： A family of compounds of formula (I) wherein: X is one of the following radicals: (a), (b), (c) which behaves as dual site acetylcholinesterase inhibitors and which are especially useful for the treatment of cognitive disorders as senile dementia, cerebrovascular dementia, mild cognition impairment, attention deficit disorder, and/or neurodegenerative dementing disease with aberrant protein aggregations as specially Alzheimer’s disease, Parkinson disease, ALS, or prion diseases, as Creutzfeldt-Jakob disease or Gerstmann-Straussler-Scheinher disease.
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公开(公告)号：EP1919465A2
公开(公告)日：2008-05-14
申请号：EP06776492.8
申请日：2006-07-28
申请人： Neuropharma S.A.
发明人： MARTÍNEZ GIL, Ana , MEDINA PADILLA, Miguel , ALONSO CASCÓN, Mercedes , FUERTES HUERTA, Ana , NAVARRO RICO, María Luisa , PÉREZ PUERTO, María José , CASTRO MORERA, Ana , MARTÍN APARICIO, Ester
CPC分类号： C07D317/66 , A61K31/17 , A61K31/36
摘要： The invention relates to urea derivatives of formula (I) as inhibitors of glycogen synthasc kinase 3², GSK-3, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which GSK-3 is involved, such as Alzheimer's disease or non-insulin dependent diabetes mellitus.
摘要翻译： 本发明涉及式（I）的脲衍生物作为糖原合成酶激酶3 2，GSK-3的抑制剂，制备这些化合物的方法，包含它们的药物组合物及其用于治疗和/或预防疾病的用途 其中涉及GSK-3，例如阿尔茨海默病或非胰岛素依赖性糖尿病。
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8.发明公开MARINE COMPOUNDS WITH CALCIUM CHANNEL BLOCKING PROPERTIES FOR THE TREATMENT OF COGNITIVE OR NEURODEGENERATIVE DISEASES 有权经过钙通道阻断性质的治疗认知或神经变性疾病CONNECTIONS海产
公开(公告)号：EP1761262A1
公开(公告)日：2007-03-14
申请号：EP05756055.9
申请日：2005-06-17
申请人： Neuropharma, S.A.
发明人： MARTÍNEZ GIL, Ana , ALONSO GORDILLO, Diana , DORRONSORO DÍAZ, Isabel , GARCÍA PALOMERO, Esther , DE AUSTRIA DE LUQUE, Celia , USÁN EGEA, Paola , DEL MONTE MILLÁN, María , MEDINA PADILLA, Miguel
IPC分类号： A61K31/42 , C07D261/20
CPC分类号： C07D261/20
摘要： The invention provides compounds having a spiro heterocyclic unit connected through a linker of a certain length to another spiro cycle, an imidazole ring or an amide group. Some of these compounds have been obtained from Aplysinia cavernicola and a mixture of Aplysina fulva and Oceanapia. The compounds exhibit VDCC blocker activity; some also show acetylcholinesterase and butyrylcholinesterase inhibition activities. Therefore they are useful in the treatment of cognitive and neurodegenerative disorders, such as brain ischemia, stroke, cognitive disorders as senile dementia, cerebrovascular dementia, mild recognition impairment, attention deficit disorder, and/or neurodegenerative dementing disease with aberrant protein aggregations as specially Alzheimers's disease or condition, or prion disease as Creutzfeld-Jakob disease or Gerstmann-Straussler-Scheinker disease.
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公开(公告)号：EP1689730A1
公开(公告)日：2006-08-16
申请号：EP04819730.5
申请日：2004-12-02
申请人： Neuropharma, S.A.
发明人： ALONSO GORDILLO, Diana , DORRONSORO DÍAZ, Isabel , MARTINEZ GIL, Ana , PANIZO DEL PLIEGO, Gema , FUERTES HUERTA, Ana , PÉREZ PUERTO, Ma José , MARTÍN APARICIO, Ester , PÉREZ NAVARRO, Darío , MEDINA PADILLA, Miguel
IPC分类号： C07D307/60 , C07D307/62 , A61K31/365 , A61P25/00 , A61P29/00 , A61P35/00
CPC分类号： C07D407/06
摘要： The present invention provides the use of a compound of formula (I); wherein: n is 0, 1, 2, or 3, the bonds shown with the dashed lines are saturated, or unsaturated with one or more double bonds; R, and R’ are independently selected from hydrogen, alkyl, aryl, -OH, -OR’’ -SH, -SR’’- NH’’ -NHR', =O, =NH, =NR'; R' is independently selected frorn alkyl, aryl, in the preparation of a medicament for the treatment of a disease requiring a GSK-3 inhibitor. Also provided is a compound of formula (II); wherein n is 0, 1, 2, or 3 the bonds shown with the dashed lines are saturated, or unsaturated with one or more double bonds. Also provided are methods of treating chronic neurodegenerative conditions.
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