公开(公告)号：EP1909912A2

公开(公告)日：2008-04-16

申请号：EP06762898.2

申请日：2006-07-28

申请人： Neuropharma S.A. ,  Instituto Biomar S.A.

发明人： MARTÍNEZ GIL, Ana ,  USÁN EGEA, Paola ,  MEDINA PADILLA, Miguel ,  GARCÍA PALOMERO, Esther ,  PÉREZ BAZ, Julia ,  FERNÁNDEZ CHIMENO, Rosa Isabel ,  FERNÁNDEZ MEDARDE, Antonio ,  CAÑEDO HERNÁNDEZ, Librada María ,  ROMERO MILLÁN, Francisco ,  CASTRO MORENA, Ana ,  ALONSO CASCÓN, Mercedes ,  SÁNCHEZ QUESADA, Jorge

IPC分类号： A61P39/06 ,  A61K31/44

CPC分类号： A61K31/44

摘要： The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment and/or prevention of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer´s Disease and Parkinson's Disease.

公开(公告)号：EP1909912B1

公开(公告)日：2012-06-06

申请号：EP06762898.2

申请日：2006-07-28

申请人： NOSCIRA, S.A. ,  Instituto Biomar S.A.

发明人： MARTÍNEZ GIL, Ana ,  USÁN EGEA, Paola ,  MEDINA PADILLA, Miguel ,  GARCÍA PALOMERO, Esther ,  PÉREZ BAZ, Julia ,  FERNÁNDEZ CHIMENO, Rosa Isabel ,  FERNÁNDEZ MEDARDE, Antonio ,  CAÑEDO HERNÁNDEZ, Librada María ,  ROMERO MILLÁN, Francisco ,  CASTRO MORERA, Ana ,  ALONSO CASCÓN, Mercedes ,  SÁNCHEZ QUESADA, Jorge

IPC分类号： A61K31/444 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  A61P3/10 ,  A61P39/06 ,  A61P9/04 ,  A61P9/10

CPC分类号： A61K31/44

摘要： The present invention relates to the use of Collismycin and derivatives thereof as inhibitors of oxidative stress in cells and their use for the preparation of medicaments for the treatment and/or prevention of oxidative stress-induced diseases or conditions, especially neurodegenerative diseases, such as Alzheimer´s Disease and Parkinson's Disease.

公开(公告)号：EP1761262A1

公开(公告)日：2007-03-14

申请号：EP05756055.9

申请日：2005-06-17

申请人： Neuropharma, S.A.

发明人： MARTÍNEZ GIL, Ana ,  ALONSO GORDILLO, Diana ,  DORRONSORO DÍAZ, Isabel ,  GARCÍA PALOMERO, Esther ,  DE AUSTRIA DE LUQUE, Celia ,  USÁN EGEA, Paola ,  DEL MONTE MILLÁN, María ,  MEDINA PADILLA, Miguel

IPC分类号： A61K31/42 ,  C07D261/20

CPC分类号： C07D261/20

摘要： The invention provides compounds having a spiro heterocyclic unit connected through a linker of a certain length to another spiro cycle, an imidazole ring or an amide group. Some of these compounds have been obtained from Aplysinia cavernicola and a mixture of Aplysina fulva and Oceanapia. The compounds exhibit VDCC blocker activity; some also show acetylcholinesterase and butyrylcholinesterase inhibition activities. Therefore they are useful in the treatment of cognitive and neurodegenerative disorders, such as brain ischemia, stroke, cognitive disorders as senile dementia, cerebrovascular dementia, mild recognition impairment, attention deficit disorder, and/or neurodegenerative dementing disease with aberrant protein aggregations as specially Alzheimers's disease or condition, or prion disease as Creutzfeld-Jakob disease or Gerstmann-Straussler-Scheinker disease.

公开(公告)号：EP1919465A2

公开(公告)日：2008-05-14

申请号：EP06776492.8

申请日：2006-07-28

申请人： Neuropharma S.A.

发明人： MARTÍNEZ GIL, Ana ,  MEDINA PADILLA, Miguel ,  ALONSO CASCÓN, Mercedes ,  FUERTES HUERTA, Ana ,  NAVARRO RICO, María Luisa ,  PÉREZ PUERTO, María José ,  CASTRO MORERA, Ana ,  MARTÍN APARICIO, Ester

IPC分类号： A61K31/17 ,  A61K31/36 ,  A61P25/28 ,  A61P3/10 ,  A61P25/24

CPC分类号： C07D317/66 ,  A61K31/17 ,  A61K31/36

摘要： The invention relates to urea derivatives of formula (I) as inhibitors of glycogen synthasc kinase 3², GSK-3, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which GSK-3 is involved, such as Alzheimer's disease or non-insulin dependent diabetes mellitus.

摘要翻译： 本发明涉及式（I）的脲衍生物作为糖原合成酶激酶3 2，GSK-3的抑制剂，制备这些化合物的方法，包含它们的药物组合物及其用于治疗和/或预防疾病的用途 其中涉及GSK-3，例如阿尔茨海默病或非胰岛素依赖性糖尿病。

公开(公告)号：EP1889619A1

公开(公告)日：2008-02-20

申请号：EP06708873.2

申请日：2006-02-10

申请人： Neuropharma, S.A.

发明人： MARTÍNEZ GIL, Ana ,  DE LUNA MEDINA, Rosario ,  PÉREZ CASTILLO, Ana ,  ALONSO CASCÓN, Mercedes

IPC分类号： A61K31/433 ,  A61P25/28 ,  C07D285/08 ,  C07D417/04

CPC分类号： C07D285/08 ,  A61K31/433

摘要： The invention relates to the use of heterocyclic compounds in the preparation of a medicament for regenerating damaged neuronal tissue.
According to a preferred embodiment, formula I compounds are used to produce a medicament for regenerating neuronal tissue in pathologies or conditions that involve neuronal damage or death in the central nervous system or peripheral nervous system.

摘要翻译： 本发明涉及杂环化合物在制备用于再生损伤的神经元组织的药物中的用途。 根据优选的实施方案，式I化合物用于产生用于在涉及中枢神经系统或周围神经系统中的神经元损伤或死亡的病理或病症中再生神经元组织的药物。

公开(公告)号：EP1761262B1

公开(公告)日：2008-12-03

申请号：EP05756055.9

申请日：2005-06-17

申请人： Neuropharma, S.A.

发明人： MARTÍNEZ GIL, Ana ,  ALONSO GORDILLO, Diana ,  DORRONSORO DÍAZ, Isabel ,  GARCÍA PALOMERO, Esther ,  DE AUSTRIA DE LUQUE, Celia ,  USÁN EGEA, Paola ,  DEL MONTE MILLÁN, María ,  MEDINA PADILLA, Miguel

IPC分类号： A61K31/42 ,  C07D261/20

CPC分类号： C07D261/20

摘要： The invention provides compounds having a spiro heterocyclic unit connected through a linker of a certain length to another spiro cycle, an imidazole ring or an amide group. Some of these compounds have been obtained from Aplysinia cavernicola and a mixture of Aplysina fulva and Oceanapia. The compounds exhibit VDCC blocker activity; some also show acetylcholinesterase and butyrylcholinesterase inhibition activities. Therefore they are useful in the treatment of cognitive and neurodegenerative disorders, such as brain ischemia, stroke, cognitive disorders as senile dementia, cerebrovascular dementia, mild recognition impairment, attention deficit disorder, and/or neurodegenerative dementing disease with aberrant protein aggregations as specially Alzheimers's disease or condition, or prion disease as Creutzfeld-Jakob disease or Gerstmann-Straussler-Scheinker disease.

公开(公告)号：EP1976823A1

公开(公告)日：2008-10-08

申请号：EP06830653.9

申请日：2006-12-15

申请人： Neuropharma, S.A.

发明人： MARTÍNEZ GIL, Ana ,  CASTRO MORERA, Ana ,  MEDINA PADILLA, Miguel ,  MUÑOZ RUIZ, Pilar ,  RUBIO ARRIETA, Laura ,  GARCÍA PALOMERO, Esther ,  DE AUSTRIA DE LUQUE, Celia ,  SÁNCHEZ QUESADA, Jorge ,  PÉREZ FERNÁNDEZ, Daniel Ignacio ,  LÓPEZ OGALLA, Javier ,  ALONSO GORDILLO, Diana

IPC分类号： C07C235/60 ,  A61K31/166 ,  A61P25/28

CPC分类号： C07C235/60

摘要： The invention is directed to a compound of formula (I) Having VDCC blocking activity. These compounds are useful for the treatment of a series of human diseases and conditions, especially cognitive or neurodegenerative diseases or conditions.