公开(公告)号：EP1007102A1

公开(公告)日：2000-06-14

申请号：EP98939753.4

申请日：1998-08-19

申请人： NYCOMED IMAGING AS

发明人： HENRIKSEN, Ingrid ,  KASPARKOVA, Vera ,  ANDERSEN, Arnfinn ,  FAHLVIK, Anne, Kjersti ,  DEG RDSTUEN, Liv, Ingrid

IPC分类号： A61K49/00

CPC分类号： A61K49/223

摘要： The invention provides a process for the preparation of a pharmaceutical composition comprising an aqueous dispersion of gas-containing vesicles the membranes whereof comprise an amphiphilic membrane-forming material, said process comprising: (i) generating a liquid dispersion of gas-containing vesicles from a mixture comprising an amphiphilic membrane forming material; (ii) lyophilizing a liquid dispersion of said gas-containing vesicles; (iii) reconstituting the lyophilized product of step (ii) with a sterile aqueous liquid to produce an aqueous dispersion of gas-containing vesicles; and (iv) treating the aqueous dispersion product of step (iii) or the lyophilized product of step (ii) to produce a substancially aggregate-free sterile aqueous dispersion of gas-containing vesicles.