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10 条记录 (耗时 0.011 秒)

    PARTICULATE COMPOSITIONS
    1.
    发明公开
    PARTICULATE COMPOSITIONS 失效
    颗粒组合物

    公开(公告)号：EP1009445A2

    公开(公告)日：2000-06-21

    申请号：EP97945974.0

    申请日：1997-11-28

    申请人： NYCOMED IMAGING AS

    发明人： OEDEGAARSTUEN, Liv Ingrid ,  DYVIK, Kari ,  BJERKNES, Kathrin ,  FAHLVIK, Anne, Kjersti

    IPC分类号： A61K49/04

    CPC分类号： A61K49/0466

    摘要： The invention provides a contrast agent composition, preferably an X-ray contrast medium, comprising vesicles in suspension in an aqueous medium, said vesicles and optionally also said aqueous medium containing an iodinated X-ray contrast agent, characterised in that a dose of said composition containing 100 mgI entrapped in said vesicles contains no more than 8x1012 vesicles.

    PROCESS FOR PREPARING CONTRAST AGENTS
    2.
    发明公开
    PROCESS FOR PREPARING CONTRAST AGENTS 有权
    用于生产造影剂

    公开(公告)号：EP1007102A1

    公开(公告)日：2000-06-14

    申请号：EP98939753.4

    申请日：1998-08-19

    申请人： NYCOMED IMAGING AS

    发明人： HENRIKSEN, Ingrid ,  KASPARKOVA, Vera ,  ANDERSEN, Arnfinn ,  FAHLVIK, Anne, Kjersti ,  DEG RDSTUEN, Liv, Ingrid

    IPC分类号： A61K49/00

    CPC分类号： A61K49/223

    摘要： The invention provides a process for the preparation of a pharmaceutical composition comprising an aqueous dispersion of gas-containing vesicles the membranes whereof comprise an amphiphilic membrane-forming material, said process comprising: (i) generating a liquid dispersion of gas-containing vesicles from a mixture comprising an amphiphilic membrane forming material; (ii) lyophilizing a liquid dispersion of said gas-containing vesicles; (iii) reconstituting the lyophilized product of step (ii) with a sterile aqueous liquid to produce an aqueous dispersion of gas-containing vesicles; and (iv) treating the aqueous dispersion product of step (iii) or the lyophilized product of step (ii) to produce a substancially aggregate-free sterile aqueous dispersion of gas-containing vesicles.

    METHOD
    4.
    发明公开
    METHOD 失效
    用于生产

    公开(公告)号：EP0930897A2

    公开(公告)日：1999-07-28

    申请号：EP97934621.0

    申请日：1997-07-30

    申请人： NYCOMED IMAGING AS

    发明人： PETTERSSON, Göran ,  GOLMAN, Klaes ,  JACOBSEN, Anne ,  DEG RDSTUEN, Liv-Ingrid ,  FAHLVIK, Anne, Kjersti

    IPC分类号： A61K49

    CPC分类号： A61K49/18 ,  A61K49/06

    摘要： The invention provides the use of a physiologically tolerable manganese compound or a salt thereof, substantially free from hydrophilic polymer components containing a significant amount of a Mn2+- chelating unit, in the manufacture of an enterally, e.g. orally or rectally, administrable MRI contrast medium composition for use in a method of imaging of a human or non-human animal body which has fasted for a period of at least 6, preferably at least 10, more preferably at least 12 hours before enteral administration of said composition. It has been found that diagnostically effective levels of uptake of orally or rectally administered manganese may be achieved using this method.

    METHOD OF T1-WEIGHTED MAGNETIC RESONANCE IMAGING OF RES ORGANS
    5.
    发明公开
    METHOD OF T1-WEIGHTED MAGNETIC RESONANCE IMAGING OF RES ORGANS 失效
    RES器官的T1加权磁共振成像方法

    公开(公告)号：EP0896546A2

    公开(公告)日：1999-02-17

    申请号：EP97914482.0

    申请日：1997-03-27

    申请人： NYCOMED IMAGING AS

    发明人： FAHLVIK, Anne, Kjersti

    IPC分类号： A61K49

    CPC分类号： A61K49/186 ,  A61K49/1863

    摘要： The invention provides a method of contrast enhanced MR angiography of the human or non-human animal body, said method comprising administering into the vasculature thereof a contrast effective amount of a contrast agent composition comprising magnetic particles having an r2/r1 ratio of no more than 5, and, at a time when sufficient of said magnetic particles remain in the vasculature to provide positive contrast enhancement thereof in a T1-weighted image while sufficient magnetic particles have been taken up into an organ of the reticuloendothelial system to provide negative contrast enhancement thereof in said T1-weighted image, generating a T1-weighted image magnetic resonance image of at least said organ.

    摘要翻译： 本发明提供了一种人或非人动物体的造影增强MR血管造影的方法，所述方法包括向其血管中施用造影剂有效量的造影剂组合物，所述造影剂组合物包含r2 / r1比率不超过 如图5所示，并且在足够的所述磁性颗粒保留在脉管系统中以在T1加权图像中提供其正增强的对比度的同时，足够的磁性颗粒已被摄取到网状内皮系统的器官中以提供其负对比度增强 在所述T1加权图像中，生成至少所述器官的T1加权图像磁共振图像。

    METHOD
    9.
    发明公开
    METHOD 失效
    用于生产

    公开(公告)号：EP0941127A2

    公开(公告)日：1999-09-15

    申请号：EP97933806.0

    申请日：1997-07-30

    申请人： NYCOMED IMAGING AS

    发明人： PETTERSSON, Göran ,  GOLMAN, Klaes ,  JACOBSEN, Anne ,  OEDEGARDSTUEN, Liv-Ingrid ,  FAHLVIK, Anne, Kjersti

    IPC分类号： A61K49

    CPC分类号： A61K49/103 ,  A61K49/1818 ,  A61K49/1887 ,  Y10S514/836

    摘要： The invention provides the use of a physiologically tolerable manganese compound or a salt thereof, in combination with a second contrast agent, preferably one which is retained within the gut and there exhibits a negative contrast effect, in the manufacture of an enterally, e.g. orally or rectally, administrable MRI contrast medium composition for use in a method of functional imaging of the gastrointestinal tract of a human or non-human animal body. This imaging technique has surprisingly been found to provide clear delineation of those portions of the gut wall in which manganese uptake is occurring, thereby enabling not only the detection of tumors in the gut, but also the identification of regions of the gut which may be functioning abnormally.

    CONTRAST AGENT
    10.
    发明公开
    CONTRAST AGENT 失效
    对比剂

    公开(公告)号：EP0783325A1

    公开(公告)日：1997-07-16

    申请号：EP94927724.0

    申请日：1994-09-27

    申请人： NYCOMED IMAGING AS ,  COCKBAIN, Julian Roderick Michaelson

    发明人： FAHLVIK, Anne, Kjersti ,  NÄVESTAD, Anne ,  GUNDERSEN, Helge ,  STRANDE, Per ,  KLAVENESS, Jo ,  JACOBSEN, Anne

    IPC分类号： A61K ,  A61K49 ,  A61K51

    CPC分类号： A61K51/1258 ,  A61K49/1854 ,  A61K49/1863 ,  A61K49/1872

    摘要： The invention relates to particulate contrast agents, especially contrast agents for MR imaging, having a metal oxide, preferably superparamagnetic iron oxide core provided with a low coating density of a polyelectrolyte coating agent selected from structural polysaccharides and synthetic polymers, especially polyaminoacids. Unlike conventional coated particulates, the new particles have reduced or no effect on cardiovascular parameters, platelet depletion, complement activation and blood coagulation.

    摘要翻译： 本发明涉及颗粒造影剂，尤其是用于MR成像的造影剂，其具有金属氧化物，优选超顺磁性氧化铁芯，其具有低涂覆密度的选自结构多糖和合成聚合物，特别是聚氨基酸的聚电解质涂覆剂。 与传统的包衣颗粒不同，新颗粒对心血管参数，血小板减少，补体活化和血液凝固的影响降低或没有影响。