公开(公告)号：EP1077730A1

公开(公告)日：2001-02-28

申请号：EP99921017.2

申请日：1999-05-11

申请人： NYCOMED IMAGING AS

发明人： HENRIKSEN, Ingrid ,  DEG RSTUEN, Liv-Ingrid ,  JACOBSEN, Tove

IPC分类号： A61K49/00

CPC分类号： A61K49/222

摘要： The invention relates to a process for the preparation of a contrast medium which process comprises: i) obtaining a composition comprising a lipid membrane in a high axial ratio conformation; ii) contacting said composition with an agent serving to release the lipid membrane from the high axial ratio conformation; and iii) agitating said composition in the presence of a biotolerable contrast generator or precursor whereby to form contrast generator or precursor containing lipid-membraned vesicles and to contrast media obtained thereby and to methods of imaging utilising said media.

公开(公告)号：EP1007102A1

公开(公告)日：2000-06-14

申请号：EP98939753.4

申请日：1998-08-19

申请人： NYCOMED IMAGING AS

发明人： HENRIKSEN, Ingrid ,  KASPARKOVA, Vera ,  ANDERSEN, Arnfinn ,  FAHLVIK, Anne, Kjersti ,  DEG RDSTUEN, Liv, Ingrid

IPC分类号： A61K49/00

CPC分类号： A61K49/223

摘要： The invention provides a process for the preparation of a pharmaceutical composition comprising an aqueous dispersion of gas-containing vesicles the membranes whereof comprise an amphiphilic membrane-forming material, said process comprising: (i) generating a liquid dispersion of gas-containing vesicles from a mixture comprising an amphiphilic membrane forming material; (ii) lyophilizing a liquid dispersion of said gas-containing vesicles; (iii) reconstituting the lyophilized product of step (ii) with a sterile aqueous liquid to produce an aqueous dispersion of gas-containing vesicles; and (iv) treating the aqueous dispersion product of step (iii) or the lyophilized product of step (ii) to produce a substancially aggregate-free sterile aqueous dispersion of gas-containing vesicles.

公开(公告)号：EP1206286A1

公开(公告)日：2002-05-22

申请号：EP00956668.8

申请日：2000-08-25

申请人： Marsden, John Christopher ,  NYCOMED IMAGING AS

发明人： HENRIKSEN, Ingrid ,  OMTVEIT, Tore ,  KASPARKOVA, Vera ,  FAHLVIK, Anne Kjersti

IPC分类号： A61K49/00 ,  A61M31/00

CPC分类号： A61K49/223

摘要： Method and apparatus for continuous infusion to a subject of dispersions in which the dispersed phase is susceptible to flotation or sedimentation. The dispersion is controllably delivered from an upper or lower extremity of an essentially vertically positioned delivery vessel, e.g. syringe (2), and is then admixed with flushing medium, e.g. from infusion minibag (8), prior to administration to the subject. Vertical positioning of the delivery device maximises the distance through which flotation or sedimentation may occur, thereby substantially reducing the effects of separation over a given period of time compared to use of a corresponding horizontal delivery vessel such as a syringe placed in a conventional syringe driver.