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公开(公告)号：EP1753712B1
公开(公告)日：2009-05-13
申请号：EP05752742.6
申请日：2005-05-25
申请人： NOVARTIS AG , Novartis Pharma GmbH
IPC分类号： C07C217/64 , C07F9/09 , A61P17/00 , A61P31/00 , A61K31/137 , A61K31/661
CPC分类号： C07C217/64 , C07C271/16 , C07F9/094
摘要： A compound of formula (I) wherein R1, R2, R3, Ra and R5 are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.
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公开(公告)号：EP1487805A1
公开(公告)日：2004-12-22
申请号：EP03744366.0
申请日：2003-03-14
申请人： Novartis AG
发明人： BAENTELI, Rolf , ZENKE, Gerhard , COOKE, Nigel, Graham , DUTHALER, Rudolf , THOMA, Gebhard , VON MATT, Anette , HONDA, Toshiyuki , MATSUURA, Naoko , NONOMURA, Kazuhiko , OHMORI, Osamu , UMEMURA, Ichiro , HINTERDING, Klaus , PAPAGEORGIOU, Christos
IPC分类号： C07D239/48 , A61K31/505 , A61P35/04
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K45/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/12 , C07D401/14 , C07D403/12 , C07D417/12
摘要： There are provided compounds of formula (I), wherein X, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as indicated in claim 1, useful in disorders where ZAP-70 and/or Syk inhibition plays a role or caused by a malfunction of signal cascades connected with FAK.
摘要翻译： 提供式（I）化合物，其中X，R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9如权利要求1中所示，可用于ZAP-70和/ 一个角色或由FAK连接的信号级联发生故障引起。
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3.发明授权AMINO-PROPANOL DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATORs 有权氨基 - 丙醇衍生物作为天冬碱-1-磷酸受体调节剂
公开(公告)号：EP1622860B1
公开(公告)日：2012-02-29
申请号：EP04730206.2
申请日：2004-04-29
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： C07C217/64 , C07C217/72 , C07D317/64 , C07F9/09 , C07F9/6574 , A61K31/661 , A61K31/137 , A61P37/02
CPC分类号： C07D317/64 , C07C217/72 , C07F9/094 , C07F9/65744
摘要： Compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, X, Y and n are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.
摘要翻译： 其中R 1，R 2，R 3，R 4，R 5，R 6，R 7，X，Y和n如说明书中所定义的式（I）化合物，其制备方法，其用途和含有它们的药物组合物。
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公开(公告)号：EP1539674A1
公开(公告)日：2005-06-15
申请号：EP03757830.9
申请日：2003-09-12
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： C07C217/72 , C07C225/16 , C07C215/28 , C07F9/09 , A61K31/137 , A61K31/661 , A61P31/00 , A61P17/00
CPC分类号： C07C217/64 , C07C215/28 , C07C225/16 , C07F9/094
摘要： Compounds of formula (I) wherein R1, R2, R3, R4 and R5 are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.
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公开(公告)号：EP1377593A2
公开(公告)日：2004-01-07
申请号：EP02727484.4
申请日：2002-03-26
申请人： Novartis AG , Novartis Pharma GmbH
发明人： ALBERT, Rainer , BAUMRUKER, Thomas , BRINKMANN, Volker , COTTENS, Sylvain , PAPAGEORGIOU, Christos , PRIESCHL-STRASSMAYR, Eva, Erika , HINTERDING, Klaus
IPC分类号： C07F9/09 , A61K31/661 , A61K31/137 , A61P31/00 , A61P17/00 , C07C225/16 , C07C271/16 , C07C217/64 , A61P19/00
CPC分类号： C07F9/65744 , C07B2200/07 , C07C217/64 , C07C225/16 , C07C271/16 , C07C2601/14 , C07F9/094 , C07F9/113 , C07F9/12
摘要： Compounds of formula (I), wherein m, R, R1 and R3 to R6 are as defined in the specification, m, is 1, 2 or 3 and X is O or a direct bond, and the corresponding unphosporylated compounds have interesting properties, e.g. immunosuppressive properties.
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6.发明公开AMINO-PROPANOL DERIVATIVES AS SPHINGOSINE-1-PHOSPHATE RECEPTOR MODULATOR 有权AMINO-PROPANOLDERIVATIVE AS鞘氨醇-1-磷酸受体的调节剂
公开(公告)号：EP1636171A2
公开(公告)日：2006-03-22
申请号：EP04739810.2
申请日：2004-06-11
申请人： Novartis AG , Novartis Pharma GmbH
发明人： EHRHARDT, Claus , HINTERDING, Klaus
IPC分类号： C07C217/72 , C07F9/09 , A61K31/137 , A61K31/661 , A61P31/00 , A61P37/02
CPC分类号： C07F9/094 , C07C217/72 , C07F9/65744
摘要： Compounds of formula (I) wherein A, R1, R2, R3, R4 and R5 as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.
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7.发明公开
公开(公告)号：EP1622860A1
公开(公告)日：2006-02-08
申请号：EP04730206.2
申请日：2004-04-29
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： C07C217/64 , C07F9/09 , A61K31/137 , A61K31/661 , A61P37/02
CPC分类号： C07D317/64 , C07C217/72 , C07F9/094 , C07F9/65744
摘要： Compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, R7, X, Y and n are as defined in the specification, processes for their production, their uses and pharmaceutical compositions containing them.
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公开(公告)号：EP1511473A2
公开(公告)日：2005-03-09
申请号：EP03730117.3
申请日：2003-05-26
申请人： Novartis AG , Novartis Pharma GmbH , IRM LLC
发明人： FAN, Ying , GAO, Wenqi , GRAY, Nathanael, S. , HINTERDING, Klaus , LEFEBVRE, Sophie , MI, Yuan , NUSSBAUMER, Peter , PAN, Shifeng , WANG, Wei , ZECRI, Frédéric , PEREZ, Lawrence, Blas , LA MONTAGNE, Kenneth, Richard , ETTMAYER, Peter
IPC分类号： A61K31/133 , C07C215/28
CPC分类号： C07D263/57 , C07C215/28 , C07C215/46 , C07C217/54 , C07C237/30 , C07C251/48 , C07C255/13 , C07C255/43 , C07C255/58 , C07C311/08 , C07C2601/02 , C07C2601/08 , C07D261/08 , C07D317/58 , C07D333/20 , C07F9/094
摘要： The present invention relates to biphenylyl derivatives, processes for their production, their uses and pharmaceutical compositions containing them.
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公开(公告)号：EP1511473B8
公开(公告)日：2013-07-24
申请号：EP03730117.3
申请日：2003-05-26
申请人： Novartis AG , Novartis Pharma GmbH , IRM LLC
发明人： FAN, Yi , GAO, Wenqi , GRAY, Nathanael, S. , HINTERDING, Klaus , LEFEBVRE, Sophie , MI, Yuan , NUSSBAUMER, Peter , PAN, Shifeng , WANG, Wei , ZECRI, Frédéric , PEREZ, Lawrence, Blas , LA MONTAGNE, Kenneth, Richard , ETTMAYER, Peter
IPC分类号： C07C215/28 , C07C215/46 , C07C217/54 , C07C237/30 , C07C251/48 , C07C255/13 , C07C255/43 , C07C255/58 , C07C311/08 , C07D261/08 , C07D317/58 , C07C333/20 , C07F9/09 , C07D263/57 , C07D333/20
CPC分类号： C07D263/57 , C07C215/28 , C07C215/46 , C07C217/54 , C07C237/30 , C07C251/48 , C07C255/13 , C07C255/43 , C07C255/58 , C07C311/08 , C07C2601/02 , C07C2601/08 , C07D261/08 , C07D317/58 , C07D333/20 , C07F9/094
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公开(公告)号：EP1511473B1
公开(公告)日：2013-04-17
申请号：EP03730117.3
申请日：2003-05-26
申请人： Novartis AG , Novartis Pharma GmbH , IRM LLC
发明人： FAN, Ying , GAO, Wenqi , GRAY, Nathanael, S. , HINTERDING, Klaus , LEFEBVRE, Sophie , MI, Yuan , NUSSBAUMER, Peter , PAN, Shifeng , WANG, Wei , ZECRI, Frédéric , PEREZ, Lawrence, Blas , LA MONTAGNE, Kenneth, Richard , ETTMAYER, Peter
IPC分类号： C07C215/28 , C07C215/46 , C07C217/54 , C07C237/30 , C07C251/48 , C07C255/13 , C07C255/43 , C07C255/58 , C07C311/08 , C07D261/08 , C07D317/58 , C07C333/20 , C07F9/09 , C07D263/57 , C07D333/20
CPC分类号： C07D263/57 , C07C215/28 , C07C215/46 , C07C217/54 , C07C237/30 , C07C251/48 , C07C255/13 , C07C255/43 , C07C255/58 , C07C311/08 , C07C2601/02 , C07C2601/08 , C07D261/08 , C07D317/58 , C07D333/20 , C07F9/094
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