公开(公告)号：EP2601956A1

公开(公告)日：2013-06-12

申请号：EP11814752.9

申请日：2011-08-05

申请人： Osaka University

发明人： TANEMURA, Masahiro ,  OMURA, Yoshiaki ,  NAGANO, Hiroaki ,  MORI, Masaki ,  DOKI, Yuichiro ,  ITO, Toshinori

IPC分类号： A61K35/12 ,  A61P3/10 ,  A61P43/00 ,  C12N5/07

CPC分类号： A61K35/39 ,  A61K35/28 ,  C12N5/0676 ,  C12N2502/1382 ,  A61K2300/00

摘要： An object of the present invention is to provide a pancreatic islet transplantation technique that enables increase of graft survival rate of pancreatic islets after pancreatic islet transplantation, to maintain survival of pancreatic islets, and to reduce the number of transplanted pancreatic islets required for normalizing blood glucose level. When performing pancreatic islet transplantation, by transplanting pancreatic islets and adipose tissue-derived stem cells together, it is possible to significantly improve graft survival rate of transplanted pancreatic islets, and reduce by half the number of transplanted pancreatic islets required for normalizing blood glucose level.

摘要翻译： 本发明的一个目的是提供一种胰岛移植技术那样使胰岛移植后的胰岛移植物的存活率，以维持胰岛的存活，并减少用于标准化血糖需要移植的胰岛的数量的增加 水平。 当执行胰岛移植，通过移植胰岛和脂肪组织来源的干细胞一起，能够显着地提高移植的胰岛的移植物存活率，并通过用于标准化的血糖水平需要移植的胰岛的数目的一半减少。

公开(公告)号：EP2601956B1

公开(公告)日：2017-04-12

申请号：EP11814752.9

申请日：2011-08-05

申请人： Osaka University

发明人： TANEMURA, Masahiro ,  OMURA, Yoshiaki ,  NAGANO, Hiroaki ,  MORI, Masaki ,  DOKI, Yuichiro ,  ITO, Toshinori

IPC分类号： A61K35/39 ,  A61P3/10 ,  A61P43/00 ,  C12N5/07 ,  A61K35/28 ,  C12N5/0775 ,  C12N5/071

CPC分类号： A61K35/39 ,  A61K35/28 ,  C12N5/0676 ,  C12N2502/1382 ,  A61K2300/00

摘要： An object of the present invention is to provide a pancreatic islet transplantation technique that enables increase of graft survival rate of pancreatic islets after pancreatic islet transplantation, to maintain survival of pancreatic islets, and to reduce the number of transplanted pancreatic islets required for normalizing blood glucose level. When performing pancreatic islet transplantation, by transplanting pancreatic islets and adipose tissue-derived stem cells together, it is possible to significantly improve graft survival rate of transplanted pancreatic islets, and reduce by half the number of transplanted pancreatic islets required for normalizing blood glucose level.

公开(公告)号：EP2537930A1

公开(公告)日：2012-12-26

申请号：EP11744730.0

申请日：2011-02-18

申请人： Osaka University

发明人： MORI, Masaki ,  ISHII, Hideshi ,  MIYOSHI, Norikatsu ,  DOKI, Yuichiro ,  TANEMURA, Masahiro ,  NAGAI, Kenichi ,  HOSHINO, Hiromitsu ,  OMURA, Yoshiaki ,  HARAGUCHI, Naotsugu ,  MIYAZAKI, Susumu

IPC分类号： C12N15/09 ,  C12N5/10 ,  C12Q1/02 ,  C12Q1/68

CPC分类号： C12N5/0696 ,  C12N2501/65 ,  C12N2506/1307 ,  C12N2506/1384 ,  G01N33/5008

摘要： A major object of the present invention is to provide a method for producing induced pluripotent stem cells with low tumorigenesis potential and high induction efficiency.
The invention provides a method for producing induced pluripotent stem cells comprising the step of introducing one or more nucleic acids that facilitate expression of at least one gene selected from the group consisting of NANOG, SOX2, OCT3/4, KLF4, LIN28, and c-MYC into somatic cells.

摘要翻译： 本发明的主要目的是提供具有低致瘤潜力和诱导效率高的诱导多能干细胞的方法。 本发明提供一种产生诱导性多能干细胞的方法，包括引入一种或多种促进至少一种选自NANOG，SOX2，OCT3 / 4，KLF4，LIN28和c- MYC进入体细胞。