公开(公告)号：EP1524974A4

公开(公告)日：2007-12-05

申请号：EP02807554

申请日：2002-05-06

申请人： PARATEK PHARM INNC

发明人： LEVY STUART B ,  ALEKSHUN MICHEAL N ,  PODLOGAR BRENT ,  OHEMENG KWASI ,  VERMA ATUL ,  WARCHOL TADEUSZ ,  BHATIA BEENA

IPC分类号： G01N33/50 ,  A61K31/341 ,  A61K31/352 ,  A61K31/40 ,  A61K31/407 ,  A61K31/409 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/4196 ,  A61K31/42 ,  A61K31/4245 ,  A61K31/429 ,  A61K31/436 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/505 ,  A61K31/506 ,  A61K31/519 ,  A61K31/53 ,  A61K31/551 ,  A61K31/553 ,  A61K31/555 ,  A61K31/7088 ,  A61K45/00 ,  A61K47/18 ,  A61K47/20 ,  A61K47/22 ,  A61K47/34 ,  A61K48/00 ,  A61P1/02 ,  A61P9/00 ,  A61P11/00 ,  A61P13/08 ,  A61P17/00 ,  A61P19/00 ,  A61P27/16 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  C07D235/08 ,  C07D235/22 ,  C07D243/10 ,  C07D253/06 ,  C07D261/20 ,  C07D307/60 ,  C07D311/30 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D413/04 ,  C07D471/04 ,  C07D487/04 ,  C07D487/14 ,  C07D491/052 ,  C07D498/04 ,  C07D498/14 ,  C07D513/04 ,  C12N15/09 ,  C12Q1/02 ,  G01N33/15 ,  A61K31/33 ,  A61K31/34 ,  A61K31/35 ,  A61K31/38 ,  A61K31/41 ,  A61K31/54

CPC分类号： A61K31/47 ,  A61K31/40 ,  A61K31/407 ,  A61K31/415 ,  A61K31/4745 ,  A61K31/505 ,  A61K31/555

摘要： Methods for identifying compound useful as anti-infectives that decrease resistance, virulence, or growth of microbes are provided. In one embodiment, the method comprises contacting a microbial cell comprising: 1) a selectable marker under the control of a transcription factor responsive element and 2) a transcription factor, with a compound under conditions which allow interaction of the compound with the microbial cell; and measuring the ability of the compound to affect the growth or survival of the microbial cell as an indication of whether the test compound modulates the activity of a transcription factor.