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1.发明授权PYRROLO[2,3-B]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 有权吡咯并[2,3-B]吡啶衍生物作为激酶抑制剂WORK，METHOD FOR THEIR和药物组合物含
公开(公告)号：EP1701956B1
公开(公告)日：2010-02-24
申请号：EP04816308.3
申请日：2004-12-23
申请人： Pfizer Italia S.r.l.
发明人： SALOM, Barbara , D'ANELLO, Matteo , BRASCA, Maria, Gabriella , GIORDANO, Patrizia , MARTINA, Katia , ANGELUCCI, Francesco , BROOKFIELD, Frederick, Arthur , TRIGG, William, John, Evotec OAI , BOYD, Edward, Andrew , LARARD, Jonathan, Anthony
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.
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2.发明授权PYRROLO[2,3-b] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING THEM 有权吡咯并[2,3-B]吡啶衍生物作为激酶抑制剂的行为; 这包括其制备方法及药物组合物，
公开(公告)号：EP1704147B1
公开(公告)日：2009-11-04
申请号：EP04804268.3
申请日：2004-12-23
申请人： Pfizer Italia S.r.l.
发明人： SALOM, Barbara , D'ANELLO, Matteo , BRASCA, Maria, Gabriella , GIORDANO, Patrizia , MARTINA, Katia , BROOKFIELD, Frederick, Arthur , TRIGG, William, John, Evotec OAI , BOYD, Edward, Andrew , LARARD, Jonathan, Anthony , TESEI, Dania
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenrative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.
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3.发明公开PYRROLO[2,3-b] PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITION COMPRISING THEM 有权吡咯并[2,3-B]吡啶衍生物作为激酶抑制剂的行为; 这包括其制备方法及药物组合物，
公开(公告)号：EP1704147A1
公开(公告)日：2006-09-27
申请号：EP04804268.3
申请日：2004-12-23
申请人： Pfizer Italia S.r.l.
发明人： SALOM, Barbara , D'ANELLO, Matteo , BRASCA, Maria, Gabriella , GIORDANO, Patrizia , MARTINA, Katia , BROOKFIELD, Frederick, Arthur , TRIGG, William, John , BOYD, Edward, Andrew , LARARD, Jonathan, Anthony , TESEI, Dania
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
CPC分类号： C07D471/04
摘要： Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenrative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.
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4.发明公开PYRROLO[2,3-B]PYRIDINE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM 有权吡咯并[2,3-B]吡啶衍生物作为激酶抑制剂WORK，METHOD FOR THEIR和药物组合物含
公开(公告)号：EP1701956A1
公开(公告)日：2006-09-20
申请号：EP04816308.3
申请日：2004-12-23
申请人： Pfizer Italia S.r.l.
发明人： SALOM, Barbara , D'ANELLO, Matteo , BRASCA, Maria, Gabriella , GIORDANO, Patrizia , MARTINA, Katia , ANGELUCCI, Francesco , BROOKFIELD, Frederick, Arthur , TRIGG, William, John , BOYD, Edward, Andrew , LARARD, Jonathan, Anthony
IPC分类号： C07D471/04 , A61K31/437
CPC分类号： C07D471/04
摘要： Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.
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5.发明授权AMINOINDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 有权AMINOINDAZOLDERIVATE与KINASEINHIBIERENDER的效果，制造方法相同，药物组合物含
公开(公告)号：EP1432416B1
公开(公告)日：2011-01-19
申请号：EP02774629.6
申请日：2002-09-19
申请人： Pfizer Italia S.r.l.
IPC分类号： A61K31/416 , C07D231/56 , C07D403/04 , A61P35/00
CPC分类号： C07D231/56 , C07D403/04 , C07D403/12
摘要： Compounds which are 3-aminoindazole derivatives or pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.
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6.发明授权PHENYLACETAMIDO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS 有权苯乙酰胺基噻唑化合物，工艺作为生产，它们作为抗肿瘤药
公开(公告)号：EP1406899B1
公开(公告)日：2006-11-15
申请号：EP02760213.5
申请日：2002-07-02
申请人： Pfizer Italia S.r.l.
发明人： PEVARELLO, Paolo , AMICI, Raffaella , VILLA, Manuela , SALOM, Barbara , VULPETTI, Anna , VARASI, Mario , BRASCA, Maria, Gabriella , TRAQUANDI, Gabriella , NESI, Marcella
IPC分类号： C07D417/12 , C07D277/46 , A61K31/425 , A61P35/00
CPC分类号： C07D417/12 , C07D277/46
摘要： Compounds represented by formula (I), as defined in the description, wherein R is a hydrogen atom or a methyl group and R1 is a group as defined in the specification, or a pharmaceutically acceptable salt thereof, are disclosed; the said compounds are useful in the treatment of cell proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
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7.发明授权ARYLMETHYL-CARBONYLAMINO-THIAZOLE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS 有权芳羰噻唑衍生物及其作为抗肿瘤药物使用
公开(公告)号：EP1204649B1
公开(公告)日：2007-10-17
申请号：EP00962760.5
申请日：2000-08-11
申请人： Pfizer Italia S.r.l.
发明人： PEVARELLO, Paolo , AMICI, Raffaella , VILLA, Manuela , SALOM, Barbara , VULPETTI, Anna , VARASI, Mario
IPC分类号： C07D277/46 , C07D417/12 , C07D417/14 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/497 , A61P35/00
CPC分类号： A61K31/426 , C07D277/46
摘要： 2-amino-1,3-thiazole derivatives represented by formula (I) or (II): where R, R1, R2 and R3 are as defined herein, or pharmaceutically acceptable salts thereof, are useful in, for example, the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenertive diseases.
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