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1.发明授权
公开(公告)号：EP1660475B1
公开(公告)日：2008-05-28
申请号：EP04763883.8
申请日：2004-08-06
申请人： Pfizer Italia S.r.l.
发明人： VANOTTI, Ermes , D'ALESSIO, Roberto , TIBOLLA, Marcellino , VARASI, Mario , MONTAGNOLI, Alessia , SANTOCANALE, Corrado , ORSINI, Paolo , PILLAN, Antonio
IPC分类号： C07D401/04 , C07D519/00 , A61K31/506 , A61K31/52 , A61P35/00 , A61P25/28 , A61P31/12 , A61P37/00 , A61P13/08 , A61P17/06 , A61P9/10 , A61P11/00 , A61P19/02 , A61P13/12 , A61K45/06
CPC分类号： C07D471/04 , A61K31/506 , A61K31/513 , A61K31/52 , A61K41/00 , A61K45/06 , A61K2300/00
摘要： Pyrimidylpyrrole derivatives of formula (1) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
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2.发明授权ARYLMETHYL-CARBONYLAMINO-THIAZOLE DERIVATIVES AND THEIR USE AS ANTITUMOR AGENTS 有权芳羰噻唑衍生物及其作为抗肿瘤药物使用
公开(公告)号：EP1204649B1
公开(公告)日：2007-10-17
申请号：EP00962760.5
申请日：2000-08-11
申请人： Pfizer Italia S.r.l.
发明人： PEVARELLO, Paolo , AMICI, Raffaella , VILLA, Manuela , SALOM, Barbara , VULPETTI, Anna , VARASI, Mario
IPC分类号： C07D277/46 , C07D417/12 , C07D417/14 , A61K31/426 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/497 , A61P35/00
CPC分类号： A61K31/426 , C07D277/46
摘要： 2-amino-1,3-thiazole derivatives represented by formula (I) or (II): where R, R1, R2 and R3 are as defined herein, or pharmaceutically acceptable salts thereof, are useful in, for example, the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenertive diseases.
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3.发明授权3(5)-UREIDO-PYRAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS 有权3（5） - 脲基 - 吡唑衍生物，它们的制备方法和用途作为抗癌药
公开(公告)号：EP1202734B1
公开(公告)日：2007-05-02
申请号：EP00955241.5
申请日：2000-08-11
发明人： PEVARELLO, Paolo , ORSINI, Paolo , TRAQUANDI, Gabriella , VARASI, Mario , FRITZEN, Edward, L. , WARPEHOSKI, Martha, A. , PIERCE, Betsy, S.
IPC分类号： A61K31/415 , A61K31/496 , C07D231/40 , C07D403/12
CPC分类号： C07D231/40 , A61K31/415 , A61K31/4155 , A61K31/4178 , A61K31/428 , A61K31/4439 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/498 , A61K31/5377
摘要： 3-ureido-pyrazole derivatives represented by formula (I): where R, R1 and R2 are as described herein, or pharmaceutically acceptable salts thereof; are useful, for example, for the treatment of cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases or neurodegenerative diseases.
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4.发明授权
公开(公告)号：EP1320531B1
公开(公告)日：2010-09-08
申请号：EP01967223.7
申请日：2001-07-25
申请人： Pfizer Italia S.r.l.
IPC分类号： C07D487/04 , C07D471/04 , A61K31/4162 , A61K31/437 , A61P35/00 , A61P25/00 , A61P31/12
CPC分类号： C07D487/04 , C07D471/04 , C40B40/00
摘要： Bicyclo-pyrazole compounds of formula (I), as herein defined, are useful for treating diseases linked to disregulated protein kinases.
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5.发明授权1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS 有权-1H-噻吩并-2,3--C - 吡唑衍生物作为激酶I-缝边
公开(公告)号：EP1711177B1
公开(公告)日：2008-05-28
申请号：EP05701307.0
申请日：2005-02-02
申请人： Pfizer Italia S.r.l.
发明人： FANCELLI, Daniele , BINDI, Simona , VARASI, Mario , VIANELLO, Paola , VIOGLIO, Sergio , TESEI, Dania
CPC分类号： C07D495/04 , A61K31/4162
摘要： Thieno[2,3-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comrising them are disclosed; the compounds of the invention may be useful in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
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6.发明授权AZAINDOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS ANTITUMOR AGENTS 有权氮杂吲哚衍生物，其制造方法及其作为抗肿瘤药
公开(公告)号：EP1309590B1
公开(公告)日：2007-09-19
申请号：EP01943522.1
申请日：2001-06-13
申请人： Pfizer Italia S.r.l.
发明人： LONGO, Antonio , BRASCA, Maria, Gabriella , ORSINI, Paolo , TRAQUANDI, Gabriella , PITTALA', Valeria , VULPETTI, Anna , VARASI, Mario , PEVARELLO, Paolo
IPC分类号： C07D471/04 , A61K31/437 , A61P35/04
CPC分类号： C07D471/04
摘要： Novel 1H-pyrrolo[2,3-b]pyridines which are represented by formula (I), as per the specification, and wherein R is a hydrogen or halogen atom or a group selected from -CN, -OH, -OCOR4, -(CH2)nNH2, -(CH2)nNHR4, -(CH2)nNHCOR4, -(CH2)nNHCONR4R5, -(CH2)nNHCOOR4, or -(CH2)nNHSO2R4, wherein n is either 0 or 1, R4 and R5 are as described in the specification; R1 is hydrogen or an optionally substituted alkyl group; R¿2? is an optionally substituted group selected from alkyl or aryl; R3 is hydrogen or a group selected from -CONR4R5, -COOR4, -CONHOR4, -SO2NHR4, alkylsulphonylaminocarbonyl or perfluorinated alkylsulphonylaminocarbonyl; or a pharmaceutically acceptable salt thereof, are disclosed; these compounds are useful for treating cell proliferative disorders associated with an altered cell cycle dependent kinase activity.
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7.发明授权PHENYLACETAMIDO-THIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS 有权苯乙酰胺基噻唑化合物，工艺作为生产，它们作为抗肿瘤药
公开(公告)号：EP1406899B1
公开(公告)日：2006-11-15
申请号：EP02760213.5
申请日：2002-07-02
申请人： Pfizer Italia S.r.l.
发明人： PEVARELLO, Paolo , AMICI, Raffaella , VILLA, Manuela , SALOM, Barbara , VULPETTI, Anna , VARASI, Mario , BRASCA, Maria, Gabriella , TRAQUANDI, Gabriella , NESI, Marcella
IPC分类号： C07D417/12 , C07D277/46 , A61K31/425 , A61P35/00
CPC分类号： C07D417/12 , C07D277/46
摘要： Compounds represented by formula (I), as defined in the description, wherein R is a hydrogen atom or a methyl group and R1 is a group as defined in the specification, or a pharmaceutically acceptable salt thereof, are disclosed; the said compounds are useful in the treatment of cell proliferative disorders, e.g. cancer, associated with an altered cell cycle dependent kinase activity.
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8.发明公开1H-THIENO 2,3-c PYRAZOLE DERIVATIVES USEFUL AS KINASE I INHIBITORS 有权2,3-C-PYRAZOL-DERIVATE ALS激酶I-HEMMER
公开(公告)号：EP1711177A1
公开(公告)日：2006-10-18
申请号：EP05701307.0
申请日：2005-02-02
申请人： Pfizer Italia S.r.l.
发明人： FANCELLI, Daniele , BINDI, Simona , VARASI, Mario , VIANELLO, Paola , VIOGLIO, Sergio , TESEI, Dania
CPC分类号： C07D495/04 , A61K31/4162
摘要： Thieno[2,3-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comrising them are disclosed; the compounds of the invention may be useful in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
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公开(公告)号：EP1660085B1
公开(公告)日：2008-10-15
申请号：EP04763848.1
申请日：2004-08-06
申请人： Pfizer Italia S.r.l.
发明人： VANOTTI, Ermes , D'ALESSIO, Roberto , TIBOLLA, Marcellino , VARASI, Mario , MONTAGNOLI, Alessia , SANTOCANALE, Corrado , MARTINA, Katia , MENICHINCHERI, Maria
IPC分类号： A61K31/444 , A61P35/00 , A61P25/28 , A61P31/12 , A61P37/00 , A61P13/08 , A61P17/06 , A61P9/10 , A61P11/00 , A61P19/02 , A61P13/12 , A61K45/06 , C07D519/00 , C07D471/04
CPC分类号： C07D471/04 , A61K31/444 , A61K31/4745 , A61K45/06 , A61K2300/00
摘要： Pyridylpyrrole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
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公开(公告)号：EP1530573B1
公开(公告)日：2008-03-19
申请号：EP03766152.7
申请日：2003-07-11
申请人： Pfizer Italia S.r.l.
IPC分类号： C07D495/04 , A61K31/4162
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04
摘要： Bicyclo-pyrazole compound of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, processes for their preparation, combinatorial libraries comprising a plurality of them and pharmaceutical compositions thereof, are herewith disclosed: the compounds of the invention are useful, in therapy, as protein kinase inhibitors, for instance in the treatment of cancer.
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