-
公开(公告)号：EP2066663B1
公开(公告)日：2011-07-06
申请号：EP07801977.5
申请日：2007-08-29
IPC分类号： C07D413/12 , A61K31/4155 , A61P3/10 , A61P29/00 , A61P25/30
CPC分类号： C07D413/12
摘要： The present invention relates to compounds of formula (I) which bind to the NRl H4 receptor (FXR) and act as agonists or partial agonists of the NRl H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds, and an enantiomer, diasterecmer, tautomer, solvate or pharmaceutically acceptable salt thereof, wherein X is (a) or (b) or (c) or (d), and the rest of the variables are as specified in claim 1.
-
公开(公告)号：EP2084147A1
公开(公告)日：2009-08-05
申请号：EP07801978.3
申请日：2007-08-29
IPC分类号： C07D401/06 , C07D401/12 , C07D413/12 , C07D413/14 , A61K31/4427 , A61K31/501 , A61K31/506 , A61P35/00
CPC分类号： C07D413/12 , C07D401/06 , C07D401/12 , C07D413/14
摘要： The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists or partial agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.
摘要翻译： 本发明涉及与NR1H4受体（FXR）结合并用作NR1H4受体（FXR）的激动剂或部分激动剂的化合物。 本发明进一步涉及所述化合物在制备用于通过所述化合物结合所述核受体来治疗疾病和/或病症的药物中的应用，以及所述化合物的合成方法。
-
3.发明公开
公开(公告)号：EP4093739A1
公开(公告)日：2022-11-30
申请号：EP21702195.5
申请日：2021-01-22
发明人： KINZEL, Olaf , STEENECK, Christoph , CZEKANSKA, Marta , PINTO, Sheena , SEKTIOGLU, Ibrahim Murathan , DEUSCHLE, Ulrich
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
-
公开(公告)号：EP3577115A1
公开(公告)日：2019-12-11
申请号：EP18707242.6
申请日：2018-02-01
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
-
公开(公告)号：EP2066663A1
公开(公告)日：2009-06-10
申请号：EP07801977.5
申请日：2007-08-29
IPC分类号： C07D413/12 , A61K31/4155 , A61P3/10 , A61P29/00 , A61P25/30
CPC分类号： C07D413/12
摘要： The present invention relates to compounds of formula (I) which bind to the NRl H4 receptor (FXR) and act as agonists or partial agonists of the NRl H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds, and an enantiomer, diasterecmer, tautomer, solvate or pharmaceutically acceptable salt thereof, wherein X is (a) or (b) or (c) or (d), and the rest of the variables are as specified in claim 1.
-
6.发明授权NOVEL 2-AMINO-4-OXOQUINAZOLONES AS LXR NUCLEAR RECEPTOR BINDING COMPOUNDS WITH PARTIAL AGONISTIC PROPERTIES 有权NEW 2-氨基-4- OXOCHINAZOLONE为部分LXR核受体激动剂
公开(公告)号：EP1536799B1
公开(公告)日：2006-05-10
申请号：EP03753402.1
申请日：2003-09-10
IPC分类号： A61K31/517 , C07D403/04 , A61P3/06
CPC分类号： C07D401/12 , C07D239/95 , C07D405/12
摘要： The present invention relates to compounds according to the general formula (I) which bind to the Liver X receptors (LXR receptors, LXRalpha/NR1H3 and LXRbeta/NR1H2) and act as selective agonists of the LXR receptors. The invention further relates to the treatment of diseases and/or conditions through binding of said nuclear receptors and selective agonistic effects by said compounds and the production of medicaments using said compounds. In particular the compounds are useful in the treatment of hypercholesterolemia, obesity or other diseases associated with elevated lipoprotein (LDL) levels.
-
公开(公告)号：EP3577115B1
公开(公告)日：2020-12-02
申请号：EP18707242.6
申请日：2018-02-01
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
-
公开(公告)号：EP2084147B1
公开(公告)日：2012-04-25
申请号：EP07801978.3
申请日：2007-08-29
IPC分类号： C07D401/06 , C07D401/12 , C07D413/12 , C07D413/14 , A61K31/4427 , A61K31/501 , A61K31/506 , A61P35/00
CPC分类号： C07D413/12 , C07D401/06 , C07D401/12 , C07D413/14
摘要： The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists or partial agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.
-
公开(公告)号：EP3577112A1
公开(公告)日：2019-12-11
申请号：EP18701774.4
申请日：2018-02-01
IPC分类号： C07D471/04 , A61K31/437 , A61P35/00
-
10.发明公开METHODS OF IDENTIFICATION OF NOVEL LIGANDS FOR MODULATION OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (NR1F3) ACTIVITY 审中-公开用于新配体的的活性NR1F3（孤儿核受体RAR相关孤儿受体-GAMMA）的调制识别方法
公开(公告)号：EP2349277A2
公开(公告)日：2011-08-03
申请号：EP09740864.5
申请日：2009-10-28
发明人： DEUSCHLE, Ulrich , ABEL, Ulrich , KREMOSER, Claus , SCHLUETER, Thomas , HOFFMANN, Thomas , PEROVIC-OTTSTADT, Sanja
IPC分类号： A61K31/575 , A61P17/06 , A61P37/06 , A61P1/00 , A61P17/00 , A61P29/00 , G01N33/50 , A61K31/551 , A61K31/192
CPC分类号： A61K31/575 , A61K31/192 , A61K31/551 , G01N33/542 , G01N33/6875 , G01N2333/70567 , G01N2500/00
摘要： The invention relates to modulators for the orphan nuclear receptor RORgamma and methods for identification and screening of novel modulators for RORgamma activity as well as methods for treating RORgamma mediated diseases with novel RORgamma modulators identified by such methods.
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.018 秒)
