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公开(公告)号：EP2066663B1
公开(公告)日：2011-07-06
申请号：EP07801977.5
申请日：2007-08-29
IPC分类号： C07D413/12 , A61K31/4155 , A61P3/10 , A61P29/00 , A61P25/30
CPC分类号： C07D413/12
摘要： The present invention relates to compounds of formula (I) which bind to the NRl H4 receptor (FXR) and act as agonists or partial agonists of the NRl H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds, and an enantiomer, diasterecmer, tautomer, solvate or pharmaceutically acceptable salt thereof, wherein X is (a) or (b) or (c) or (d), and the rest of the variables are as specified in claim 1.
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公开(公告)号：EP2084147A1
公开(公告)日：2009-08-05
申请号：EP07801978.3
申请日：2007-08-29
IPC分类号： C07D401/06 , C07D401/12 , C07D413/12 , C07D413/14 , A61K31/4427 , A61K31/501 , A61K31/506 , A61P35/00
CPC分类号： C07D413/12 , C07D401/06 , C07D401/12 , C07D413/14
摘要： The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists or partial agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.
摘要翻译： 本发明涉及与NR1H4受体（FXR）结合并用作NR1H4受体（FXR）的激动剂或部分激动剂的化合物。 本发明进一步涉及所述化合物在制备用于通过所述化合物结合所述核受体来治疗疾病和/或病症的药物中的应用，以及所述化合物的合成方法。
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公开(公告)号：EP2467366A1
公开(公告)日：2012-06-27
申请号：EP10747171.6
申请日：2010-08-19
IPC分类号： C07D249/06 , C07D261/08 , C07D413/04 , C07D413/12 , C07D413/14 , A61K31/4192 , A61K31/42 , A61K31/443 , A61K31/4439 , A61P1/16 , A61P3/10 , A61P35/00
CPC分类号： C07D261/08 , A61K31/4192 , A61K31/42 , A61K31/422 , A61K31/423 , A61K31/4439 , C07D249/06 , C07D413/04 , C07D413/12 , C07D413/14 , Y02A50/409 , Y02A50/414 , Y02A50/415
摘要： The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.
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公开(公告)号：EP2066663A1
公开(公告)日：2009-06-10
申请号：EP07801977.5
申请日：2007-08-29
IPC分类号： C07D413/12 , A61K31/4155 , A61P3/10 , A61P29/00 , A61P25/30
CPC分类号： C07D413/12
摘要： The present invention relates to compounds of formula (I) which bind to the NRl H4 receptor (FXR) and act as agonists or partial agonists of the NRl H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds, and an enantiomer, diasterecmer, tautomer, solvate or pharmaceutically acceptable salt thereof, wherein X is (a) or (b) or (c) or (d), and the rest of the variables are as specified in claim 1.
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公开(公告)号：EP2467366B1
公开(公告)日：2014-11-12
申请号：EP10747171.6
申请日：2010-08-19
IPC分类号： C07D249/06 , C07D261/08 , C07D413/04 , C07D413/12 , C07D413/14 , A61K31/4192 , A61K31/42 , A61K31/443 , A61K31/4439 , A61P1/16 , A61P3/10 , A61P35/00
CPC分类号： C07D261/08 , A61K31/4192 , A61K31/42 , A61K31/422 , A61K31/423 , A61K31/4439 , C07D249/06 , C07D413/04 , C07D413/12 , C07D413/14 , Y02A50/409 , Y02A50/414 , Y02A50/415
摘要： The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.
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6.发明公开METHODS OF IDENTIFICATION OF NOVEL LIGANDS FOR MODULATION OF ORPHAN NUCLEAR RECEPTOR RAR-RELATED ORPHAN RECEPTOR-GAMMA (NR1F3) ACTIVITY 审中-公开用于新配体的的活性NR1F3（孤儿核受体RAR相关孤儿受体-GAMMA）的调制识别方法
公开(公告)号：EP2349277A2
公开(公告)日：2011-08-03
申请号：EP09740864.5
申请日：2009-10-28
发明人： DEUSCHLE, Ulrich , ABEL, Ulrich , KREMOSER, Claus , SCHLUETER, Thomas , HOFFMANN, Thomas , PEROVIC-OTTSTADT, Sanja
IPC分类号： A61K31/575 , A61P17/06 , A61P37/06 , A61P1/00 , A61P17/00 , A61P29/00 , G01N33/50 , A61K31/551 , A61K31/192
CPC分类号： A61K31/575 , A61K31/192 , A61K31/551 , G01N33/542 , G01N33/6875 , G01N2333/70567 , G01N2500/00
摘要： The invention relates to modulators for the orphan nuclear receptor RORgamma and methods for identification and screening of novel modulators for RORgamma activity as well as methods for treating RORgamma mediated diseases with novel RORgamma modulators identified by such methods.
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公开(公告)号：EP2084147B1
公开(公告)日：2012-04-25
申请号：EP07801978.3
申请日：2007-08-29
IPC分类号： C07D401/06 , C07D401/12 , C07D413/12 , C07D413/14 , A61K31/4427 , A61K31/501 , A61K31/506 , A61P35/00
CPC分类号： C07D413/12 , C07D401/06 , C07D401/12 , C07D413/14
摘要： The present invention relates to compounds which bind to the NR1H4 receptor (FXR) and act as agonists or partial agonists of the NR1H4 receptor (FXR). The invention further relates to the use of the compounds for the preparation of a medicament for the treatment of diseases and/or conditions through binding of said nuclear receptor by said compounds, and to a process for the synthesis of said compounds.
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