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公开(公告)号：EP4065699A1
公开(公告)日：2022-10-05
申请号：EP20834006.7
申请日：2020-11-27
申请人： PROMEGA CORPORATION
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公开(公告)号：EP3783011A1
公开(公告)日：2021-02-24
申请号：EP20197758.4
申请日：2014-03-13
申请人： Promega Corporation
发明人： DIXON, Andrew S. , ENCELL, Lance P. , HALL, Mary P. , WOOD, Keith V. , WOOD, Monika G. , SCHWINN, Marie , BINKOWSKI, Brock , ZEGZOUTI, Hicham , NATH, Nidhi , MONDAL, Subhanjan , GOUELI, Said , MEISENHEIMER, Poncho , KIRKLAND, Thomas , UNCH, James , PULUKKUNAT, Dileep K. , ROBERS, Matthew B. , DART, Melanie , MACHLEIDT, Thomas
IPC分类号： C07K14/435 , G01N33/50
摘要： Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide.
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公开(公告)号：EP3953374A1
公开(公告)日：2022-02-16
申请号：EP20788198.8
申请日：2020-04-10
申请人： Promega Corporation
发明人： KIRKLAND, Thomas , DART, Melanie , ZENG, Zhiyang , SMITH, Thomas , WOOD, Keith , MACHLEIDT, Thomas , JOST, Emily , KINCAID, Virginia , WANG, Hui , ZHOU, Wenhui , ENCELL, Lance , HALL, Mary , HURST, Robin
IPC分类号： C07K14/435 , C12N9/02 , C07K7/08 , G01N33/542 , C12Q1/66 , A61J1/20
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4.发明公开
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公开(公告)号：EP3887830A2
公开(公告)日：2021-10-06
申请号：EP19824222.4
申请日：2019-11-27
申请人： Promega Corporation
发明人： WANG, Hu , NATH, Nidhi , FLEMMING, Rod , GODAT, Becky , ZHOU, Wenhui , KINCAID, Virginia , DART, Melanie
IPC分类号： G01N33/58 , C07K14/37 , C07K14/54 , C07K14/735 , C07K16/24 , C07D207/46
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公开(公告)号：EP3807419A2
公开(公告)日：2021-04-21
申请号：EP19820498.4
申请日：2019-06-12
申请人： Promega Corporation
发明人： HALL, Mary , ENCELL, Lance P. , KILLORAN, Michael , WOOD, Keith , SMITH, Thomas , KINCAID, Virginia , KIRKLAND, Thomas , DART, Melanie
IPC分类号： C12Q1/68
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公开(公告)号：EP2970412A1
公开(公告)日：2016-01-20
申请号：EP14769752.8
申请日：2014-03-13
申请人： Promega Corporation
发明人： DIXON, Andrew, S. , ENCELL, Lance , HALL, Mary , WOOD, Keith , WOOD, Monika , SCHWINN, Marie , BINKOWSKI, Brock, F. , ZEGZOUTI, Hicham , NATH, Nidhi , MONDAL, Subhanjan , GOUELI, Said , MEISENHEIMER, Poncho , KIRKLAND, Thomas , UNCH, James , PULUKKUNAT, Dileep, K. , ROBERS, Matthew , DART, Melanie , MACHLEIDT, Thomas
IPC分类号： C07K14/435
CPC分类号： G01N33/533 , A61K51/08 , C07K7/08 , C07K14/43509 , C12N9/0069 , C12Q1/66 , G01N33/542 , G01N33/581
摘要： Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide.
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公开(公告)号：EP4455668A2
公开(公告)日：2024-10-30
申请号：EP24198006.9
申请日：2016-02-05
申请人： Promega Corporation
发明人： DART, Melanie , ENCELL, Lance P. , KIRKLAND, Thomas , MACHLEIDT, Thomas , ROBERS, Matthew , BINKOWSKI, Brock F. , WOOD, Keith , SHI, Ce
IPC分类号： G01N33/566
摘要： Provided herein are systems and methods for characterizing target/ligand engagement. In particular, luciferase-labeled polypeptide targets are used to detect or quantify target/ligand engagement (e.g., within a cell or cell lysate).
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公开(公告)号：EP3254113A1
公开(公告)日：2017-12-13
申请号：EP16747366.9
申请日：2016-02-05
申请人： Promega Corporation
发明人： DART, Melanie , ENCELL, Lance P. , KIRKLAND, Thomas , MACHLEIDT, Thomas , ROBERS, Matthew , BINKOWSKI, Brock F. , WOOD, Keith , SHI, Ce
IPC分类号： G01N33/58 , G01N33/566
CPC分类号： G01N33/6845 , C12Y113/12007 , G01N21/6428 , G01N33/56916 , G01N33/581 , G01N33/582 , G01N2021/6432 , G01N2021/6439 , G01N2333/90241 , G01N2500/04 , G01N2500/10
摘要： Provided herein are systems and methods for characterizing target/ligand engagement. In particular, luciferase-labeled polypeptide targets are used to detect or quantify target/ligand engagement (e.g., within a cell or cell lysate).
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