利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

9 条记录 (耗时 0.014 秒)

    Novel cephalosporin compounds
    1.
    发明公开
    Novel cephalosporin compounds 失效
    新型头孢菌素化合物

    公开(公告)号：EP0335390A2

    公开(公告)日：1989-10-04

    申请号：EP89105616.0

    申请日：1989-03-30

    申请人： SAGAMI CHEMICAL RESEARCH CENTER

    发明人： Kobori, Takeo ,  Tunemoto, Daiei

    IPC分类号： C07D501/24 ,  C07D501/18 ,  A61K31/545

    CPC分类号： C07D501/24 ,  C07D501/18 ,  Y02P20/55

    摘要： Cephalosporin compounds represented by the general formula
    in which R¹ is a hydrogen atom or a protective group for the amino group,
    R² is a hydrogen atom or a protective group for the hydroxyl group,
    R³ is a hydrogen atom, a self-forming cation or a protective group for the carboxyl group, and
    R⁴ is a hydrogen atom, a halogen atom or a lower alkyl group,
    and their pharmacologically acceptable salts, process for their production and use of the same compounds as medica­ments, particularly as antibiotic agents.

    摘要翻译： 由通式表示的头孢菌素化合物，其中R 1是氢原子或氨基的保护基，R 2是氢原子或羟基的保护基，R 3是氢原子，自生阳离子或 羧基保护基，R 4是氢原子，卤素原子或低级烷基，及其药理学上可接受的盐，它们的制备方法及其与药物相同的化合物的用途，特别是作为抗生素剂。

    Novel cephalosporin compounds
    3.
    发明公开
    Novel cephalosporin compounds 失效
    新型CEPHOLOSPORIN化合物

    公开(公告)号：EP0335390A3

    公开(公告)日：1991-05-02

    申请号：EP89105616.0

    申请日：1989-03-30

    申请人： SAGAMI CHEMICAL RESEARCH CENTER

    发明人： Kobori, Takeo ,  Tunemoto, Daiei

    IPC分类号： C07D501/24 ,  C07D501/18 ,  A61K31/545

    CPC分类号： C07D501/24 ,  C07D501/18 ,  Y02P20/55

    摘要： Cephalosporin compounds represented by the general formula
    in which R¹ is a hydrogen atom or a protective group for the amino group,
    R² is a hydrogen atom or a protective group for the hydroxyl group,
    R³ is a hydrogen atom, a self-forming cation or a protective group for the carboxyl group, and
    R⁴ is a hydrogen atom, a halogen atom or a lower alkyl group,
    and their pharmacologically acceptable salts, process for their production and use of the same compounds as medica­ments, particularly as antibiotic agents.

    Beta-lactam compounds and process for the preparation thereof
    9.
    发明公开
    Beta-lactam compounds and process for the preparation thereof 失效
    Beta-Lactamderivate和Verfahren zu ihrer Herstellung。

    公开(公告)号：EP0082498A2

    公开(公告)日：1983-06-29

    申请号：EP82111732.2

    申请日：1982-12-17

    申请人： SAGAMI CHEMICAL RESEARCH CENTER

    发明人： Tunemoto, Daiei ,  Kobori, Takeo ,  Kondo, Kiyosi ,  Murakami, Yasuo ,  Toshioka, Tadashi ,  Sakuma, Osamu ,  Kojima, Etsuko

    IPC分类号： C07D501/20 ,  C07D499/50 ,  C07D277/38

    CPC分类号： C07D277/20 ,  C07C57/58 ,  C07D277/42 ,  C07D499/00 ,  Y02P20/55

    摘要： There are disclosed a compound having the following formula:
    in which R 1 denotes a substituted or unsubstituted thiazolyl radical, a substituted or unsubstituted thiazolylmercapto radical or a substituted or unsubstituted phenyl radical; R 2 denotes a halogen atom, a cyano radical, a carbamoyl radical, a lower-alkylmercapto radical or an 0-lower-alkylcarboxyimidoyl radical; and Y represents a group
    (wherein R 3 denotes hydrogen, a salt forming cation or a protective group for a carboxylic acid, and R denotes hydrogen or a residue of a nucleophilic compound); process for preparing the same; and an intermediate compound useful for preparing the same.
    The above mentioned compound has a broad antibacterial spectrum and shows strong antibacterial activities against not only gram-positive bacteria but also gram-negative bacteria, particularly the resistive gram-negative becteria.

    摘要翻译： 公开了具有下式的化合物：其中R 1表示取代或未取代的噻唑基，取代或未取代的噻唑基巯基或取代或未取代的苯基的 R 2表示卤素原子，氰基，氨基甲酰基，低级烷基巯基或O-低级烷基羧基亚氨基; Y表示（其中R 3表示氢，成盐阳离子或羧酸保护基，R 4表示氢或亲核化合物的残基）。 制备方法; 和可用于制备该中间体的中间体化合物。 上述化合物具有广泛的抗菌谱，并且对革兰氏阳性细菌，革兰氏阴性细菌，特别是抗性革兰氏阴性菌也表现出强烈的抗菌活性。