公开(公告)号：EP3620472A1

公开(公告)日：2020-03-11

申请号：EP19201382.9

申请日：2014-08-13

申请人： Sanofi

发明人： PRITSKER, Alla ,  GRAILHE, Patrick ,  RAK, Alexey ,  MATHIEU, Magali ,  MORGAN, Christopher Ryan ,  BAURIN, Nicolas ,  POIRIER, Bruno ,  DAVEU, Cyril ,  DUFFIEUX, Francis ,  LI, Han ,  KOMINOS, Dorothea ,  JANIAK, Philip

IPC分类号： C07K16/38

摘要： The invention provides antibodies that specifically bind to Plasminogen Activator Inhibitor type-1 (PAI-1). The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-PAI-1 antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies to modulate PAI-1 activity or detect PAI-1, either in vitro or in vivo, are also provided. The disclosure further provides methods of making antibodies that specifically bind to PAI-1 in the active conformational state.

公开(公告)号：EP3033359B1

公开(公告)日：2019-11-06

申请号：EP14761451.5

申请日：2014-08-13

申请人： SANOFI

发明人： PRITSKER, Alla ,  GRAILHE, Patrick ,  RAK, Alexey ,  MATHIEU, Magali ,  MORGAN, Christopher Ryan ,  BAURIN, Nicolas ,  POIRIER, Bruno ,  DAVEU, Cyril ,  DUFFIEUX, Francis ,  LI, Han ,  KOMINOS, Dorothea ,  JANIAK, Philip

IPC分类号： C07K16/38

公开(公告)号：EP3033359A1

公开(公告)日：2016-06-22

申请号：EP14761451.5

申请日：2014-08-13

申请人： SANOFI

发明人： PRITSKER, Alla ,  GRAILHE, Patrick ,  RAK, Alexey ,  MATHIEU, Magali ,  MORGAN, Christopher Ryan ,  BAURIN, Nicolas ,  POIRIER, Bruno ,  DAVEU, Cyril ,  DUFFIEUX, Francis ,  LI, Han ,  KOMINOS, Dorothea ,  JANIAK, Philip

IPC分类号： C07K16/38

摘要： The invention provides antibodies that specifically bind to Plasminogen Activator inhibitor type-1 (PAI-1), The invention also provides pharmaceutical compositions, as well as nucleic acids encoding anti-PAI-1 antibodies, recombinant expression vectors and host cells for making such antibodies, or fragments thereof. Methods of using antibodies to modulate PAI-1 activity or detect PAI-1, either in vitro or in vivo, are also provided. The disclosure further provides methods of making antibodies that specifically bind to PAI-1 in the active conformational state.

摘要翻译： 本发明提供了特异性结合纤溶酶原激活物抑制剂1型（PAI-1）的抗体。本发明还提供了药物组合物，以及编码抗PAI-1抗体的核酸，用于制备这种抗体的重组表达载体和宿主细胞 ，或其片段。 还提供了在体外或体内使用抗体调节PAI-1活性或检测PAI-1的方法。 本公开进一步提供了制备特异性结合活性构象状态的PAI-1的抗体的方法。

公开(公告)号：EP4271709A1

公开(公告)日：2023-11-08

申请号：EP21840696.5

申请日：2021-12-30

申请人： Sanofi ,  Innate Pharma

发明人： GAUTHIER, Laurent ,  THIELENS, Ariane ,  ROSSI, Benjamin ,  AMARA, Céline ,  NICOLAZZI, Céline ,  CHIRON, Marielle ,  DUFFIEUX, Francis ,  VIRONE-ODDOS, Angela ,  BENINGA, Jochen

IPC分类号： C07K16/28 ,  A61P35/02 ,  A61K39/395 ,  A61P35/00