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公开(公告)号:EP4271709A1
公开(公告)日:2023-11-08
申请号:EP21840696.5
申请日:2021-12-30
申请人: Sanofi , Innate Pharma
发明人: GAUTHIER, Laurent , THIELENS, Ariane , ROSSI, Benjamin , AMARA, Céline , NICOLAZZI, Céline , CHIRON, Marielle , DUFFIEUX, Francis , VIRONE-ODDOS, Angela , BENINGA, Jochen
IPC分类号: C07K16/28 , A61P35/02 , A61K39/395 , A61P35/00
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公开(公告)号:EP3958898A1
公开(公告)日:2022-03-02
申请号:EP20726267.6
申请日:2020-04-23
申请人: SANOFI
发明人: CAMERON, Béatrice , CHIRON BLONDEL, Marielle , DUMAS, Jacques , FOURNIER, Alain , KINGSBURY, Jonathan , LEMOINE, Cendrine , MURRAY, Brian , OSTBERG, Nathan , PATKE, Sanket , VIRONE-ODDOS, Angela , ZHANG, Zichuan
IPC分类号: A61K39/395 , C07K16/28 , A61P35/00 , A61K39/00
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3.ANTI-TUMORAL COMPOSITION COMPRISING A PI3KBETA-SELECTIVE INHIBITOR AND A PI3KALPHA-SELECTIVE INHIBITOR 审中-公开
标题翻译: WITH A PI3KBETA选择性抑制剂AND A PI3KALPHA选择性抑制剂抗肿瘤药物组合物公开(公告)号:EP2981261A1
公开(公告)日:2016-02-10
申请号:EP14714736.7
申请日:2014-04-03
申请人: SANOFI
IPC分类号: A61K31/4439 , A61K31/513 , A61K45/06 , A61P35/00
CPC分类号: A61K31/5377 , A61K31/4439 , A61K31/513 , A61K45/06 , A61K2300/00
摘要: The present invention concerns a combination of a PI3Kβ selective inhibitor with a PI3Kα selective inhibitor for use in the treatment of cancer.
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4.ANTI-TUMORAL COMPOSITION COMPRISING A PI3KBETA INHIBITOR AND A RAF INHIBITOR, TO OVERCOME CANCER CELLS RESISTANCE 审中-公开
标题翻译: 与β抑制剂PI3K和RAF抑制剂克服癌细胞抵抗抗肿瘤药物组合物公开(公告)号:EP2968350A1
公开(公告)日:2016-01-20
申请号:EP14710274.3
申请日:2014-03-14
申请人: SANOFI
IPC分类号: A61K31/538 , A61K31/437 , A61P35/00
CPC分类号: A61K31/5377 , A61K31/437 , A61K31/5375 , A61K45/06 , G01N33/5011 , G01N33/5017 , G01N33/57496 , A61K2300/00
摘要: The present invention concerns a combination of a ΡΙ3Κβ inhibitor with a RAF inhibitor for its use for the treatment of a patient resistant to at least one RAF inhibitor, a kit comprising the same, its pharmaceutical uses thereof and a method of monitoring the efficiency of said combination when administered to a patient.
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5.COMPOSITIONS AND METHODS FOR TREATING CANCER USING PI3K BETA INHIBITOR AND MAPK PATHWAY INHIBITOR, INCLUDING MEK AND RAF INHIBITORS 审中-公开
标题翻译: 组合物和方法用于治疗癌症使用PI3K抑制剂和β-MAPK-线列车抑制剂,包括MEK和RAF抑制剂公开(公告)号:EP2755653A1
公开(公告)日:2014-07-23
申请号:EP12759137.8
申请日:2012-09-14
申请人: SANOFI
IPC分类号: A61K31/4184 , A61K31/437 , A61K31/5377 , A61K45/06 , A61P35/00
CPC分类号: A61K31/5377 , A61K31/4184 , A61K31/437 , A61K45/06 , A61K2300/00
摘要: The present invention relates to compositions comprising at least one MAPK pathway inhibitor including MEK and RAF inhibitors and at least one ΡΙ3Κβ inhibitor, and also to uses thereof for the treatment of cancer.
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