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1.发明授权TRICYCLIC COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES 失效TRYCYCLISCHE衍生物用于抑制G-蛋白质功能和用于治疗增生性疾病
公开(公告)号：EP0814807B1
公开(公告)日：2003-05-07
申请号：EP96909646.0
申请日：1996-03-20
申请人： SCHERING CORPORATION
IPC分类号： A61K31/445 , A61K31/44 , A61P35/00
CPC分类号： A61K31/4545 , A61K31/4439
摘要： A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a novel compound of formula (Ia), (Ib) or (Ic) wherein: R and R are H, alkyl, halogeno, OH, alkoxy, NH2, alkylamino, dialkylamino, CF3, SO3H, CO2R , NO2, SO2NH2, or CONHR ; n is 0 or 1; R is a group of the formula R C(O)-, R CH2C(O)-, R C(R )2C(O)-, R SO2-, R CH2SO2-, R SCH2C(O)-, R OC(O)-, R NHC(O)-, R C(O)C(O)- or R SC(O)-; R is alkyl, aryl, arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl or heterocycloalkyl; and R is alkyl or C(R )2 is a carboxyclic ring; or pharmaceutically acceptable salts thereof.
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公开(公告)号：EP1725235B1
公开(公告)日：2009-04-15
申请号：EP05712200.4
申请日：2005-02-02
申请人： Schering Corporation
发明人： TING, Pauline C. , CAO, Jianhua , DONG, Youhao , GILBERT, Eric J. , HUANG, Ying , KELLY, Joseph M. , MCCOMBIE, Stuart , SHIH, Neng-Yang
IPC分类号： A61K31/4709 , A61K31/444 , A61P11/06 , C07D401/04 , C07D401/14
CPC分类号： C07D401/14 , C07D211/18 , C07D211/58 , C07D401/04 , C07D471/04
摘要： The use of CCR3 antagonists of the formula (I) or a pharmaceutically acceptable salt thereof for the treatment of asthma is disclosed, as well as novel compounds of the formula (II), pharmaceutical compositions comprising them, and their use in the treatment of asthma, wherein R, Ra, X, Xa, R1, R2, R2a, R14, R14a, R16 and n are as defined in the specification.
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公开(公告)号：EP1725235A1
公开(公告)日：2006-11-29
申请号：EP05712200.4
申请日：2005-02-02
申请人： SCHERING CORPORATION
发明人： TING, Pauline C. , CAO, Jianhua , DONG, Youhao , GILBERT, Eric J. , HUANG, Ying , KELLY, Joseph M. , MCCOMBIE, Stuart , SHIH, Neng-Yang
IPC分类号： A61K31/4709 , A61K31/444 , A61P11/06 , C07D401/04 , C07D401/14
CPC分类号： C07D401/14 , C07D211/18 , C07D211/58 , C07D401/04 , C07D471/04
摘要： The use of CCR3 antagonists of the formula (I) or a pharmaceutically acceptable salt thereof for the treatment of asthma is disclosed, as well as novel compounds of the formula (II), pharmaceutical compositions comprising them, and their use in the treatment of asthma, wherein R, Ra, X, Xa, R1, R2, R2a, R14, R14a, R16 and n are as defined in the specification.
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4.发明公开TRICYCLIC COMPOUNDS USEFUL FOR INHIBITION OF G-PROTEIN FUNCTION AND FOR TREATMENT OF PROLIFERATIVE DISEASES 失效TRYCYCLISCHE衍生物用于抑制G-蛋白质功能和用于治疗增生性疾病
公开(公告)号：EP0814807A1
公开(公告)日：1998-01-07
申请号：EP96909646.0
申请日：1996-03-20
申请人： SCHERING CORPORATION
CPC分类号： A61K31/4545 , A61K31/4439
摘要： A method of inhibiting Ras function and therefore inhibiting cellular growth is disclosed. The method comprises the administration of a novel compound of formula (Ia), (Ib) or (Ic) wherein: R and R1 are H, alkyl, halogeno, OH, alkoxy, NH¿2?, alkylamino, dialkylamino, CF3, SO3H, CO2R?3, NO¿2, SO2NH2, or CONHR4; n is 0 or 1; R2 is a group of the formula R5C(O)-, R5CH2C(O)-, R5C(R6)2C(O)-, R5SO2-, R5CH2SO2-, R5SCH2C(O)-, R5OC(O)-, R5NHC(O)-, R5C(O)C(O)- or R5SC(O)-; R5 is alkyl, aryl, arylalkyl, arylalkenyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl or heterocycloalkyl; and R6 is alkyl or C(R6)2 is a carboxyclic ring; or pharmaceutically acceptable salts thereof.
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