公开(公告)号：EP2337842A4

公开(公告)日：2013-09-11

申请号：EP09813375

申请日：2009-09-10

申请人： SEARETE LLC

发明人： BANGERA MAHALAXMI GITA ,  HARLOW ED ,  HYDE RODERICK A ,  ISHIKAWA MURIEL Y ,  JUNG EDWARD K Y ,  KARE JORDIN T ,  LEUTHARDT ERIC C ,  MYHRVOLD NATHAN P ,  RIVET DENNIS J ,  SWEENEY ELIZABETH A ,  TEGREENE CLARENCE T ,  WOOD LOWELL L JR ,  WOOD VICTORIA Y H

IPC分类号： C01B31/02 ,  B82Y30/00 ,  B82Y40/00

CPC分类号： A61K47/48776 ,  A61K38/1703 ,  A61K38/1732 ,  A61K47/48215 ,  A61K47/48646 ,  A61K47/60 ,  A61K47/6871 ,  A61K47/6901 ,  B82Y5/00 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01B21/0648 ,  C01B31/0253 ,  C01B31/0273 ,  C01B32/168 ,  C01B32/174 ,  C01B2202/02 ,  C01B2202/34 ,  C01B2202/36 ,  C01P2004/13 ,  C07K16/32 ,  Y10S977/743 ,  Y10S977/75 ,  Y10S977/762 ,  Y10S977/788 ,  Y10S977/795 ,  Y10S977/848 ,  Y10S977/896 ,  Y10S977/915

摘要： Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.