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12 条记录 (耗时 0.012 秒)

    Substituted benzoate derivatives
    6.
    发明公开
    Substituted benzoate derivatives 失效
    取代苯甲酸衍生物。

    公开(公告)号：EP0580378A1

    公开(公告)日：1994-01-26

    申请号：EP93305630.1

    申请日：1993-07-19

    申请人： SHIONOGI & CO., LTD.

    发明人： Matsutani, Shigeru ,  Yoshida, Tadashi ,  Sakazaki, Ryuji ,  Fujii, Yasuhiko ,  Tanaka, Kazushige

    IPC分类号： C07C69/92 ,  C07C229/38 ,  C07C271/20 ,  A61K31/235

    CPC分类号： C07C271/22 ,  C07C69/92 ,  C07C229/38

    摘要： The present invention relates to the compounds of the formula:

    in which R¹, R², R³, R⁴, R⁵, R⁶, R⁷, and R⁸ are independently hydrogen, lower alkyl which is optionally substituted, lower alkoxy which is optionally substituted, hydroxy, acyloxy, or halogen; R⁹ is hydrogen, hydroxy, acyloxy, lower alkyl which is optionally substituted, lower alkoxy which is optionally substituted, or lower alkylamino which is optionally substituted; E¹ is hydrogen, or an ester residue; m is an integer of from 1 to 4;
    or a pharmaceutically acceptable salt thereof. The compounds of the present invention exhibit phospholipase A₂ inhibitory activity, and can be used in treating inflammatory conditions.

    摘要翻译： 本发明涉及下式的化合物：其中R 1，R 2，R 3，R 4，R 5，R 6，R 7， R 8独立地为氢，任选取代的低级烷基，任选取代的低级烷氧基，羟基，酰氧基或卤素; R 9是氢，羟基，酰氧基，任选被取代的低级烷基，任选被取代的低级烷氧基或任选取代的低级烷基氨基; E 1是氢或酯残基; m为1〜4的整数， 或其药学上可接受的盐。 本发明化合物表现出磷脂酶A2抑制活性，可用于治疗炎性病症。

    9-(Substituted thio)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives, their manufacture and use
    7.
    发明公开
    9-(Substituted thio)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives, their manufacture and use 失效
    9-（取代的噻吩基）-4H-吡咯并[1,2-a]嘧啶-4-酮衍生物及其制备和使用

    公开(公告)号：EP0218423A3

    公开(公告)日：1988-01-20

    申请号：EP86307404

    申请日：1986-09-25

    申请人： SHIONOGI & CO., LTD.

    发明人： Matsutani, Shigeru ,  Mizushima, Yukio ,  Doteuchi, Masami

    IPC分类号： C07D471/04 ,  A61K31/505 ,  C07D235/00 ,  C07D221/00

    CPC分类号： C07D471/04

    摘要： 9-(Substituted thio)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives of the formula:
    wherein n is 0 or 1, R is -COR 1 , -CONR 4 R 5 or -CH 2 R 6 , R 1 is C 1 -C 5 alkyl, C 3 -C 7 cycloalkyl, allylthio, styryl, phenoxymethyl, thienylmethyl, C 6 -C 10 aryl optionally substituted, benzyl optionally substituted or 5- or 6-membered heterocyclic group optionally substituted, R 2 and R 3 each is hydrogen, C l -C 5 alkyl, carboxy, C 2 -C 5 alkoxycarbonyl or benzyloxycarbonyl optionally substituted, R 4 and R 5 each is hydrogen, C l -C 5 alkyl, C 3 -C 7 cycloalkyl or phenyl optionally substituted, and R 6 is pyridyl or phenyl optionally substituted are useful as antiulcer agents and may be provided by several routes.

    9-(Substituted thio)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives, their manufacture and use
    8.
    发明公开
    9-(Substituted thio)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives, their manufacture and use 失效
    （9-取代硫基）-4H-吡啶并[1,2-a]嘧啶-4-酮衍生物，它们的制备和用途。

    公开(公告)号：EP0218423A2

    公开(公告)日：1987-04-15

    申请号：EP86307404.3

    申请日：1986-09-25

    申请人： SHIONOGI & CO., LTD.

    发明人： Matsutani, Shigeru ,  Mizushima, Yukio ,  Doteuchi, Masami

    IPC分类号： C07D471/04 ,  A61K31/505

    CPC分类号： C07D471/04

    摘要： 9-(Substituted thio)-4H-pyrido[1,2-a]pyrimidin-4-one derivatives of the formula:
    wherein n is 0 or 1, R is -COR 1 , -CONR 4 R 5 or -CH 2 R 6 , R 1 is C 1 -C 5 alkyl, C 3 -C 7 cycloalkyl, allylthio, styryl, phenoxymethyl, thienylmethyl, C 6 -C 10 aryl optionally substituted, benzyl optionally substituted or 5- or 6-membered heterocyclic group optionally substituted, R 2 and R 3 each is hydrogen, C l -C 5 alkyl, carboxy, C 2 -C 5 alkoxycarbonyl or benzyloxycarbonyl optionally substituted, R 4 and R 5 each is hydrogen, C l -C 5 alkyl, C 3 -C 7 cycloalkyl or phenyl optionally substituted, and R 6 is pyridyl or phenyl optionally substituted are useful as antiulcer agents and may be provided by several routes.