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1.发明公开
公开(公告)号：EP2197842A1
公开(公告)日：2010-06-23
申请号：EP08795611.6
申请日：2008-08-27
申请人： Schering Corporation
发明人： ANILKUMAR, Gopinadhan, N. , BENNETT, Frank , CHAN, Tin-Yau , CHEN, Kevin, X. , SANNIGRAHI, Mousumi , VELAZQUEZ, Francisco , VENKATRAMAN, Srikanth , ZENG, Qingbei , DUCA, Jose, S. , LESBURG, Charles, A. , KOZLOWSKI, Joseph, A. , NJOROGE, F., George , ROSENBLUM, Stuart, B. , SHIH, Neng-Yang , GAVALAS, Stephen, J. , JIANG, Yueheng , PINTO, Patrick, A. , PU, Haiyan , SELYUTIN, Oleg, B. , VIBULBHAN, Bancha , WANG, Li , WU, Wanli , YANG, Weiying , HUANG, Yuhua , HUANG, Hsueh-Cheng , PALERMO, Robert , FELD, Boris
IPC分类号： C07D209/42 , C07D401/04 , C07D401/14 , A61K31/404 , A61P31/12
CPC分类号： C07D417/14 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to 2,3-Substituted Indole Derivatives, compositions comprising at least one 2,3-Substituted Indole Derivative, and methods of using the 2,3-Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
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2.发明公开NOVEL KETOAMIDES WITH CYCLIC P4'S AS INHIBITORS OF NS3 SERINE PROTEASE OF HEPATITIS C VIRUS 有权与来自丙型肝炎病毒NS3丝氨酸蛋白酶的抗循环P4作为抑制剂NEW酮酰胺
公开(公告)号：EP1730142A1
公开(公告)日：2006-12-13
申请号：EP05723688.7
申请日：2005-02-24
申请人： SCHERING CORPORATION
发明人： CHEN, Kevin, X. , NJOROGE, F., George , SANNIGRAHI, Mousumi , NAIR, Latha, G. , YANG, Weiying , VIBULBHAN, Bancha , VENKATRAMAN, Srikanth , ARASAPPAN, Ashok , BOGEN, Stephane, L. , BENNETT, Frank , GIRIJAVALLABHAN, Viyyoor, M.
IPC分类号： C07D417/12 , C07D513/04 , C07D401/12 , C07D209/52 , C07K5/08 , A61K31/40 , A61P31/12
CPC分类号： C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/0205 , C12Q1/707
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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3.发明授权
公开(公告)号：EP2197842B1
公开(公告)日：2012-05-23
申请号：EP08795611.6
申请日：2008-08-27
申请人： Schering Corporation
发明人： ANILKUMAR, Gopinadhan, N. , BENNETT, Frank , CHAN, Tin-Yau , CHEN, Kevin, X. , SANNIGRAHI, Mousumi , VELAZQUEZ, Francisco , VENKATRAMAN, Srikanth , ZENG, Qingbei , DUCA, Jose, S. , LESBURG, Charles, A. , KOZLOWSKI, Joseph, A. , NJOROGE, F., George , ROSENBLUM, Stuart, B. , SHIH, Neng-Yang , GAVALAS, Stephen, J. , JIANG, Yueheng , PINTO, Patrick, A. , PU, Haiyan , SELYUTIN, Oleg, B. , VIBULBHAN, Bancha , WANG, Li , WU, Wanli , YANG, Weiying , HUANG, Yuhua , HUANG, Hsueh-Cheng , PALERMO, Robert , FELD, Boris
IPC分类号： C07D209/42 , C07D401/04 , C07D401/14 , A61K31/404 , A61P31/12
CPC分类号： C07D417/14 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to 2,3-Substituted Indole Derivatives, compositions comprising at least one 2,3-Substituted Indole Derivative, and methods of using the 2,3-Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
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4.发明授权NOVEL KETOAMIDES WITH CYCLIC P4'S AS INHIBITORS OF NS3 SERINE PROTEASE OF HEPATITIS C VIRUS 有权与来自丙型肝炎病毒NS3丝氨酸蛋白酶的抗循环P4作为抑制剂NEW酮酰胺
公开(公告)号：EP1730142B1
公开(公告)日：2011-06-29
申请号：EP05723688.7
申请日：2005-02-24
申请人： Schering Corporation
发明人： CHEN, Kevin, X. , NJOROGE, F., George , SANNIGRAHI, Mousumi , NAIR, Latha, G. , YANG, Weiying , VIBULBHAN, Bancha , VENKATRAMAN, Srikanth , ARASAPPAN, Ashok , BOGEN, Stephane, L. , BENNETT, Frank , GIRIJAVALLABHAN, Viyyoor, M.
IPC分类号： C07D417/12 , C07D513/04 , C07D401/12 , C07D209/52 , C07K5/08 , A61K31/40 , A61P31/12
CPC分类号： C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/0205 , C12Q1/707
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
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5.发明公开NOVEL PEPTIDOMIMETIC NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS 审中-公开丙型肝炎病毒的新肽模拟抑制剂NS3丝氨酸蛋白酶
公开(公告)号：EP1664090A2
公开(公告)日：2006-06-07
申请号：EP04782000.6
申请日：2004-08-24
申请人： SCHERING CORPORATION
发明人： CHEN, Kevin, X. , NJOROGE, F. George , YANG, Weiying , VIBULBHAN, Bancha , GIRIJAVALLABHAN, Viyyoor, M. , VENKATRAMAN, Srikanth , VELAZQUEZ, Francisco
CPC分类号： C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/021 , C07K5/0827 , C07K7/06
摘要： The present application discloses a compound, or enantiomers, stereoisomers, rotamers, tautomers or racemates of said compound, or pharmaceutically acceptable salts or solvates of said compound, said compound having the general structure shown in Formula (1): useful in the treatment or prevention or amelioration of one or more symptoms of hepatitis C.
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