公开(公告)号：EP2408761A1

公开(公告)日：2012-01-25

申请号：EP08795629.8

申请日：2008-08-27

申请人： Schering Corporation

发明人： ANILKUMAR, Gopinadhan, N. ,  BENNETT, Frank ,  CHAN, Tin-Yau ,  CHEN, Kevin, X. ,  SANNIGRAHI, Mousumi ,  VELAZQUEZ, Francisco ,  VENKATRAMAN, Srikanth ,  ZENG, Qingbei ,  DUCA, Jose, S. ,  LESBURG, Charles, A. ,  KOZLOWSKI, Joseph, A. ,  NJOROGE, F., George ,  ROSENBLUM, Stuart, B. ,  SHIH, Neng-Yang

IPC分类号： C07D401/04 ,  C07D403/04 ,  A61K31/513 ,  A61P31/12

CPC分类号： C07D403/04 ,  C07D401/04

摘要： The present invention relates to Substituted Indole Derivatives, compositions comprising at least one Substituted Indole Derivative, and methods of using these Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.

公开(公告)号：EP2376078A2

公开(公告)日：2011-10-19

申请号：EP09775047.5

申请日：2009-12-10

申请人： Schering Corporation

发明人： MACCOSS, Malcolm ,  NJOROGE, F., George ,  BENNETT, Frank ,  VENKATRAMAN, Srikanth ,  KOZLOWSKI, Joseph, A. ,  YU, Wensheng ,  McNAMARA, Paul, E. ,  ROYSTER, Pernilla, R.

IPC分类号： A61K31/403 ,  A61K31/7056 ,  A61K38/21 ,  A61P31/14 ,  A61K45/06 ,  A61K38/05 ,  C07K5/06

CPC分类号： A61K31/403 ,  A61K31/7056 ,  A61K38/21 ,  A61K38/212 ,  A61K45/06 ,  A61K47/64 ,  C07K5/06052 ,  A61K2300/00

摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as wet! as methods of using them to treat disorders associated with the HCV protease An illustrative inventsve compound is shown below: Formula (I).

公开(公告)号：EP2197884A2

公开(公告)日：2010-06-23

申请号：EP08795628.0

申请日：2008-08-27

申请人： Schering Corporation

发明人： BENNETT, Frank ,  ZENG, Qingbei ,  VENKATRAMAN, Srikanth ,  SANNIGRAHI, Mousumi ,  CHEN, Kevin, X. ,  ANILKUMAR, Gopinadhan, N. ,  ROSENBLUM, Stuart, B. ,  KOZLOWSKI, Joseph, A. ,  NJOROGE, F., George

IPC分类号： C07D491/052 ,  C07D498/04 ,  A61K31/436

CPC分类号： C07D498/04 ,  C07D491/052

摘要： The present invention relates to Tetracyclic Indole Derivatives, compositions comprising at least one Tetracyclic Indole Derivative, and methods of using the Tetracyclic Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.

公开(公告)号：EP1282632A1

公开(公告)日：2003-02-12

申请号：EP01928662.4

申请日：2001-04-18

申请人： SCHERING CORPORATION

发明人： GANGULY, Ashit, K. ,  MCCORMICK, Jinping ,  LOVEY, Raymond, G. ,  BENNETT, Frank ,  SAKSENA, Anil, K. ,  GIRIJAVALLABHAN, Viyyoor, M.

IPC分类号： C07H19/056 ,  A61K31/7056 ,  A61P31/12

CPC分类号： C07H19/056 ,  Y10S514/894

摘要： Ribavirin derivatives represented by the formula (II), pharmaceutical compositions containing them as well as the use of the ribavirin derivatives represented by the formula (II) for the preparation of a medicament for the treatment of susceptible viral infections, for example, chronic hepatitis C infections administrating, the ribavirin derivatives being represented by formula (II) are disclosed.

公开(公告)号：EP1730165A1

公开(公告)日：2006-12-13

申请号：EP05724112.7

申请日：2005-02-24

申请人： SCHERING CORPORATION

发明人： BOGEN, Stephane, L. ,  PAN, Weidong ,  RUAN, Sumei ,  CHEN, Kevin, X. ,  ARASAPPAN, Ashok ,  VENKATRAMAN, Srikanth ,  NAIR, Latha, G. ,  SANNIGRAHI, Mousumi ,  BENNETT, Frank ,  SAKSENA, Anil, K. ,  NJOROGE, F., George ,  GIRIJAVALLABHAN, Viyyoor, M.

IPC分类号： C07K5/02 ,  C07D209/52 ,  C07D417/12 ,  C07D401/12 ,  C07D409/12 ,  C07D403/12 ,  C07D407/12 ,  C07D413/12 ,  C07D491/04 ,  C07D209/70 ,  C07D495/10 ,  C07D207/10 ,  C07D295/16 ,  A61K31/403 ,  A61K31/427

CPC分类号： C07D209/52 ,  A61K38/00 ,  C07D209/02 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12 ,  C07K5/0205 ,  C07K5/0808 ,  C07K5/0812 ,  C07K5/0827

摘要： The present invention discloses novel compounds of formula (I) which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

公开(公告)号：EP1730142A1

公开(公告)日：2006-12-13

申请号：EP05723688.7

申请日：2005-02-24

申请人： SCHERING CORPORATION

发明人： CHEN, Kevin, X. ,  NJOROGE, F., George ,  SANNIGRAHI, Mousumi ,  NAIR, Latha, G. ,  YANG, Weiying ,  VIBULBHAN, Bancha ,  VENKATRAMAN, Srikanth ,  ARASAPPAN, Ashok ,  BOGEN, Stephane, L. ,  BENNETT, Frank ,  GIRIJAVALLABHAN, Viyyoor, M.

IPC分类号： C07D417/12 ,  C07D513/04 ,  C07D401/12 ,  C07D209/52 ,  C07K5/08 ,  A61K31/40 ,  A61P31/12

CPC分类号： C07K5/0202 ,  A61K31/40 ,  A61K38/00 ,  C07K5/0205 ,  C12Q1/707

摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

公开(公告)号：EP0736030B1

公开(公告)日：2001-08-29

申请号：EP95906620.0

申请日：1994-12-20

申请人： SCHERING CORPORATION

发明人： SAKSENA, Anil, K. ,  GIRIJAVALLABHAN, Viyyoor, M. ,  LOVEY, Raymond, G. ,  PIKE, Russell, E. ,  WANG, Haiyan ,  LIU, Yi-Tsung ,  GANGULY, Ashit, K. ,  BENNETT, Frank

IPC分类号： C07D521/00 ,  C07F9/6558 ,  A61K31/495 ,  A61K31/66

CPC分类号： C07D249/08 ,  C07D231/12 ,  C07D233/56 ,  C07F9/65586

摘要： A compound represented by formula (I) wherein X is independently both F or both Cl or one X is independently F and the other is independently Cl; R1 is a straight or branched chain (C3 to C8) alkyl group substituted by one or two hydroxy moieties, an ether or ester (e.g., a polyestherester or phosphate ester) thereof a pharmaceutically acceptable salt thereof and pharmaceutical compositions thereof useful for treating and/or preventing fungal infections are disclosed.

公开(公告)号：EP1121369A1

公开(公告)日：2001-08-08

申请号：EP99970662.5

申请日：1999-10-14

申请人： SCHERING CORPORATION

发明人： GANGULY, Ashit, K. ,  MCCORMICK, Jinping ,  LOVEY, Raymond, G. ,  BENNETT, Frank ,  SAKSENA, Anil, K. ,  GIRIJAVALLABHAN, Viyyoor, M.

IPC分类号： C07H19/056 ,  A61K31/70

CPC分类号： C07H19/056

摘要： A method for treating a patient having chronic hepatitis C infection to eradicate detectable HCV-RNA involving a combination therapy using a therapeutically effective amount of ribavirin derivative of formula (I) and a therapeutically effective amount of interferon-alpha for a time period of from 20 up to 80 weeks.

摘要翻译： 一种治疗患有慢性丙型肝炎感染的患者以根除可检测的HCV-RNA的方法，涉及组合疗法，使用治疗有效量的式（I）的利巴韦林衍生物和治疗有效量的干扰素-α，时间为20 长达80周。

公开(公告)号：EP2197842B1

公开(公告)日：2012-05-23

申请号：EP08795611.6

申请日：2008-08-27

申请人： Schering Corporation

发明人： ANILKUMAR, Gopinadhan, N. ,  BENNETT, Frank ,  CHAN, Tin-Yau ,  CHEN, Kevin, X. ,  SANNIGRAHI, Mousumi ,  VELAZQUEZ, Francisco ,  VENKATRAMAN, Srikanth ,  ZENG, Qingbei ,  DUCA, Jose, S. ,  LESBURG, Charles, A. ,  KOZLOWSKI, Joseph, A. ,  NJOROGE, F., George ,  ROSENBLUM, Stuart, B. ,  SHIH, Neng-Yang ,  GAVALAS, Stephen, J. ,  JIANG, Yueheng ,  PINTO, Patrick, A. ,  PU, Haiyan ,  SELYUTIN, Oleg, B. ,  VIBULBHAN, Bancha ,  WANG, Li ,  WU, Wanli ,  YANG, Weiying ,  HUANG, Yuhua ,  HUANG, Hsueh-Cheng ,  PALERMO, Robert ,  FELD, Boris

IPC分类号： C07D209/42 ,  C07D401/04 ,  C07D401/14 ,  A61K31/404 ,  A61P31/12

CPC分类号： C07D417/14 ,  C07D209/42 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

摘要： The present invention relates to 2,3-Substituted Indole Derivatives, compositions comprising at least one 2,3-Substituted Indole Derivative, and methods of using the 2,3-Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.

公开(公告)号：EP1730142B1

公开(公告)日：2011-06-29

申请号：EP05723688.7

申请日：2005-02-24

申请人： Schering Corporation

发明人： CHEN, Kevin, X. ,  NJOROGE, F., George ,  SANNIGRAHI, Mousumi ,  NAIR, Latha, G. ,  YANG, Weiying ,  VIBULBHAN, Bancha ,  VENKATRAMAN, Srikanth ,  ARASAPPAN, Ashok ,  BOGEN, Stephane, L. ,  BENNETT, Frank ,  GIRIJAVALLABHAN, Viyyoor, M.

IPC分类号： C07D417/12 ,  C07D513/04 ,  C07D401/12 ,  C07D209/52 ,  C07K5/08 ,  A61K31/40 ,  A61P31/12

CPC分类号： C07K5/0202 ,  A61K31/40 ,  A61K38/00 ,  C07K5/0205 ,  C12Q1/707

摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.