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公开(公告)号：EP2279202B1
公开(公告)日：2015-08-12
申请号：EP09734345.3
申请日：2009-04-21
发明人： BEUERMAN, Roger, W. , LIU, Shouping , LI, Jing , ZHOU, Lei , VERMA, Chandra, Shekhar , TAN, Donald
IPC分类号： C07K14/47 , C07K14/435 , C12N15/00 , A61K38/17 , A61P31/04
CPC分类号： C07K14/4723 , A61K38/00 , C07K2319/00
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公开(公告)号：EP2279202A1
公开(公告)日：2011-02-02
申请号：EP09734345.3
申请日：2009-04-21
发明人： BEUERMAN, Roger, W. , LIU, Shouping , LI, Jing , ZHOU, Lei , VERMA, Chandra, Shekhar , TAN, Donald
IPC分类号： C07K14/47 , C07K14/435 , C12N15/00 , A61K38/17 , A61P31/04
CPC分类号： C07K14/4723 , A61K38/00 , C07K2319/00
摘要： The invention relates to multimeric forms of antimicrobial peptides, for example, defensin peptides. The multimeric forms of defensin peptides possesses antimicrobial activity and may be formulated into antimicrobial compositions, pharmaceutical compositions, eyedrop composition, contact lens solution compositions for coating medical devices and the like. The invention also relates to the use of these multimeric forms of peptides, e.g. multimeric forms of defensin peptides for inhibiting and/or reducing the growth of microorganisms in general, including in a host. The invention further relates to a method of preparing multimers of peptides derived from defensins, for example hBD3.
摘要翻译： 本发明涉及多聚体形式的抗微生物肽，例如防卫素肽。 防卫素肽的多聚体形式具有抗微生物活性，并且可以配制成抗微生物组合物，药物组合物，眼药水组合物，用于涂覆医疗装置的隐形眼镜溶液组合物等。 本发明还涉及这些多聚体形式的肽的应用，例如， 通常包括在宿主中用于抑制和/或减少微生物生长的多聚体形式的防御素肽。 本发明进一步涉及制备衍生自防御素例如hBD3的肽的多聚体的方法。
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公开(公告)号：EP2010561A1
公开(公告)日：2009-01-07
申请号：EP07748666.0
申请日：2007-04-27
发明人： BEUERMAN, Roger , ZHOU, Lei , LIU, Shouping , LI, Jing , SURESH, Anita , VERMA, Chandra Shekhar , TAN, Donald
CPC分类号： A61K38/1729 , A61K38/00 , C07K14/4723 , Y02A50/473
摘要： There is provided at least one isolated antimicrobial peptide, wherein the peptide is a linear analog of hBD3 or a fragment thereof. In particular, there is provided a linear analog of hBD3 wherein the peptide has a reduced cytotoxicity to at least one cell compared to the wild type hBD3.
摘要翻译： 提供了至少一种分离的抗微生物肽，其中所述肽是hBD3或其片段的线性类似物。 具体而言，提供了hBD3的线性类似物，其中所述肽与野生型hBD3相比对至少一种细胞具有降低的细胞毒性。
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公开(公告)号：EP2013618B1
公开(公告)日：2013-04-10
申请号：EP07748663.7
申请日：2007-04-26
发明人： BEUERMAN, Roger , ZHOU, Lei , LIU, Shouping , YANG, He , TAN, Donald
CPC分类号： G01N33/6893 , C12Q1/527 , G01N33/6848 , G01N2800/16 , G01N2800/52 , Y10S424/811 , Y10T436/24
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公开(公告)号：EP2013618A1
公开(公告)日：2009-01-14
申请号：EP07748663.7
申请日：2007-04-26
发明人： BEUERMAN, Roger , ZHOU, Lei , LIU, Shouping , YANG, He , TAN, Donald
CPC分类号： G01N33/6893 , C12Q1/527 , G01N33/6848 , G01N2800/16 , G01N2800/52 , Y10S424/811 , Y10T436/24
摘要： The present invention relates to diagnosis and/or treatment of medical conditions. The present invention relates to new method of diagnosing dry mucosa condition in a subject. The condition may be dry eye. The present invention also provides a method to monitor the efficacy of a treatment of a dry mucosa condition, a method of treating a dry mucosa condition and/or a diagnostic kit for a dry mucosa condition.
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公开(公告)号：EP4112055A1
公开(公告)日：2023-01-04
申请号：EP22189717.6
申请日：2017-05-24
申请人： Singapore Health Services Pte Ltd , Nanyang Technological University , Santen Pharmaceutical Co., Ltd.
发明人： TAN, Donald , BEUERMAN, Roger , ASADA, Hiroyuki , SAKANAKA, Koji , MORIMOTO, Takashi , FUJISAWA, Toyomi , TAKAHASHI, Kyohei
IPC分类号： A61K31/46 , A61K9/08 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/26 , A61K47/38
摘要： Disclosed herein is an aqueous composition comprising 0.001 - 0.1 % (w/v) atropine or a salt thereof, and a phosphate buffer, which is at a pH range of 6 or lower.
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公开(公告)号：EP2875124A1
公开(公告)日：2015-05-27
申请号：EP13820042.3
申请日：2013-07-18
发明人： TAN, Donald , MEHTA, Jodhbir , PEH, Swee Lim Gary
CPC分类号： C12N5/0621 , C12N2500/24 , C12N2500/25 , C12N2500/30 , C12N2500/32 , C12N2500/34 , C12N2500/38 , C12N2500/62 , C12N2500/72 , C12N2500/80 , C12N2501/06 , C12N2501/10 , C12N2501/31 , C12N2501/33 , C12N2501/39
摘要： The invention relates to a dual-media approach for culturing isolated corneal endothelial cells. Isolated corneal endothelial cells are first contacted with a proliferative medium to propagate and/or expand the endothelial cells followed by a maintenance medium to preserve the morphology and/or characteristics of the corneal endothelial cells. The invention includes the proliferative medium and the maintenance medium and also a combination of the two medium.
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公开(公告)号：EP2875124B1
公开(公告)日：2019-03-27
申请号：EP13820042.3
申请日：2013-07-18
发明人： TAN, Donald , MEHTA, Jodhbir , PEH, Swee Lim Gary
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公开(公告)号：EP3463360A1
公开(公告)日：2019-04-10
申请号：EP17802848.6
申请日：2017-05-24
申请人： Singapore Health Services Pte Ltd , Nanyang Technological University , Santen Pharmaceutical Co., Ltd.
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公开(公告)号：EP2616025A1
公开(公告)日：2013-07-24
申请号：EP11824649.5
申请日：2011-09-13
发明人： TAN, Donald , MEHTA, Jodhbir
CPC分类号： A61F9/00834 , A01N1/0226 , A61F2/145 , A61F2/16 , A61F9/00831 , A61F9/013 , A61F2009/00872 , A61F2009/0088 , A61F2009/00895
摘要： The present invention is directed to a method for performing a reversible refractive procedure by reimplanting a refractive lenticule that has been obtained by a refractive procedure on the eye, the method comprising the steps of preparing the refractive lenticule for reimplantation, creating a corneal flap in an eye of an acceptor, transferring the refractive lenticule under the corneal flap, and repositioning and covering the acceptor's corneal flap; thereby reimplanting the refractive lenticule. The present invention is also directed to a refractive lenticule obtained by a refractive procedure on the eye of a donor for use in a method for subsequent reimplantation in a reversible refractive procedure on an acceptor, wherein the refractive lenticule is stored at a temperature below 0°C.
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