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公开(公告)号：EP4112055A1
公开(公告)日：2023-01-04
申请号：EP22189717.6
申请日：2017-05-24
申请人： Singapore Health Services Pte Ltd , Nanyang Technological University , Santen Pharmaceutical Co., Ltd.
发明人： TAN, Donald , BEUERMAN, Roger , ASADA, Hiroyuki , SAKANAKA, Koji , MORIMOTO, Takashi , FUJISAWA, Toyomi , TAKAHASHI, Kyohei
IPC分类号： A61K31/46 , A61K9/08 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/26 , A61K47/38
摘要： Disclosed herein is an aqueous composition comprising 0.001 - 0.1 % (w/v) atropine or a salt thereof, and a phosphate buffer, which is at a pH range of 6 or lower.
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公开(公告)号：EP3463360A1
公开(公告)日：2019-04-10
申请号：EP17802848.6
申请日：2017-05-24
申请人： Singapore Health Services Pte Ltd , Nanyang Technological University , Santen Pharmaceutical Co., Ltd.
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3.发明公开
公开(公告)号：EP3418294A1
公开(公告)日：2018-12-26
申请号：EP18173555.6
申请日：2013-09-09
CPC分类号： C07K7/06 , A61K38/00 , C07K14/001
摘要： The invention relates to an isolated peptide tetramer comprising the formula [(RGRKWRR) 2 K] 2 KK and its derivatives thereof. The derivatives may comprise at least one amino acid substitution, at least one amino acid deletion, a rearrangement of the peptide monomer and/or at least one non-proteogenic amino acid modification in at least one peptide monomer. The isolated peptide tetramer and derivatives thereof have antimicrobial (antibacterial, antifungal and/or anti-protozoan) properties.
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公开(公告)号：EP3969448A1
公开(公告)日：2022-03-23
申请号：EP20809100.9
申请日：2020-05-18
申请人： Singapore Health Services Pte. Ltd. , Agency for Science, Technology and Research , Tan Tock Seng Hospital Pte Ltd
发明人： AUNG, Thet Tun , LI, Jianguo , KOH, Jun Jie , RAJAMANI, Lakshminarayanan , BEUERMAN, Roger , TAN, Tiang Hwee Donald , PERIAYAH, Mercy Halleluyah , VERMA, Chandra Shekhar , CHEN, Swaine , BARKHAM, Timothy
IPC分类号： C07D401/14 , C07D405/14 , A61K31/4433 , A61K31/444 , A61P31/04
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公开(公告)号：EP3585386A1
公开(公告)日：2020-01-01
申请号：EP18756627.8
申请日：2018-02-20
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6.发明授权
公开(公告)号：EP2892914B1
公开(公告)日：2018-05-23
申请号：EP13834677.0
申请日：2013-09-09
CPC分类号： C07K7/06 , A61K38/00 , C07K14/001
摘要： An isolated peptide tetramer includes the formula [(RGRKVVRR)2K]2KK and its derivatives thereof. The derivatives may include at least one amino acid substitution, at least one amino acid deletion, a rearrangement of the peptide monomer and/or at least one non-proteogenic amino acid modification in at least one peptide monomer. The isolated peptide tetramer and derivatives thereof have antimicrobial (antibacterial, antifungal and/or anti-protozoan) properties.
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公开(公告)号：EP2010561A1
公开(公告)日：2009-01-07
申请号：EP07748666.0
申请日：2007-04-27
发明人： BEUERMAN, Roger , ZHOU, Lei , LIU, Shouping , LI, Jing , SURESH, Anita , VERMA, Chandra Shekhar , TAN, Donald
CPC分类号： A61K38/1729 , A61K38/00 , C07K14/4723 , Y02A50/473
摘要： There is provided at least one isolated antimicrobial peptide, wherein the peptide is a linear analog of hBD3 or a fragment thereof. In particular, there is provided a linear analog of hBD3 wherein the peptide has a reduced cytotoxicity to at least one cell compared to the wild type hBD3.
摘要翻译： 提供了至少一种分离的抗微生物肽，其中所述肽是hBD3或其片段的线性类似物。 具体而言，提供了hBD3的线性类似物，其中所述肽与野生型hBD3相比对至少一种细胞具有降低的细胞毒性。
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8.发明公开TETRABRANCHED PEPTIDES AND ANALOGUES AS A NEW CLASS OF ANTIMICROBIALS AND THEIR PREPARATION THEREOF 有权TETRA支化肽和类似物抗菌剂及其生产一类新
公开(公告)号：EP2892914A1
公开(公告)日：2015-07-15
申请号：EP13834677.0
申请日：2013-09-09
CPC分类号： C07K7/06 , A61K38/00 , C07K14/001
摘要： The invention relates to an isolated peptide tetramer comprising the formula [(RGRKWRR)2K]2KK and its derivatives thereof. The derivatives may comprise at least one amino acid substitution, at least one amino acid deletion, a rearrangement of the peptide monomer and/or at least one non-proteogenic amino acid modification in at least one peptide monomer. The isolated peptide tetramer and derivatives thereof have antimicrobial (antibacterial, antifungal and/or anti-protozoan) properties.
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公开(公告)号：EP2013618B1
公开(公告)日：2013-04-10
申请号：EP07748663.7
申请日：2007-04-26
发明人： BEUERMAN, Roger , ZHOU, Lei , LIU, Shouping , YANG, He , TAN, Donald
CPC分类号： G01N33/6893 , C12Q1/527 , G01N33/6848 , G01N2800/16 , G01N2800/52 , Y10S424/811 , Y10T436/24
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公开(公告)号：EP2013618A1
公开(公告)日：2009-01-14
申请号：EP07748663.7
申请日：2007-04-26
发明人： BEUERMAN, Roger , ZHOU, Lei , LIU, Shouping , YANG, He , TAN, Donald
CPC分类号： G01N33/6893 , C12Q1/527 , G01N33/6848 , G01N2800/16 , G01N2800/52 , Y10S424/811 , Y10T436/24
摘要： The present invention relates to diagnosis and/or treatment of medical conditions. The present invention relates to new method of diagnosing dry mucosa condition in a subject. The condition may be dry eye. The present invention also provides a method to monitor the efficacy of a treatment of a dry mucosa condition, a method of treating a dry mucosa condition and/or a diagnostic kit for a dry mucosa condition.
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