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1.发明公开
公开(公告)号：EP2619238A1
公开(公告)日：2013-07-31
申请号：EP11827074.3
申请日：2011-08-11
发明人： GAO, Jinming , BOOTHMAN, David , ZHOU, Kejin , HUANG, Xiaonan , WANG, Yiguang
IPC分类号： C08F220/34 , C08F226/10 , C08F287/00 , A61K31/79 , C08F271/02 , C08F293/00 , A61K47/32 , C08F283/06 , G01N21/64
CPC分类号： C08F293/005 , A61K9/1075 , A61K9/1273 , A61K9/5031 , A61K31/337 , A61K31/352 , A61K31/704 , A61K47/58 , A61K47/62 , A61K47/6811 , A61K47/6845 , A61K49/0032 , A61K49/005 , A61K49/0054 , A61K49/0056 , A61K49/0082 , C07D311/92 , C08F220/34 , C08F2438/01
摘要： Provided herein are block copolymers comprising a hydrophilic polymer segment and a hydrophobic polymer segment, wherein the hydrophilic polymer segment comprises a polymer selected from the group consisting of: poly(ethylene oxide) (PEO), poly(methacrylate phosphatidyl choline) (MPC), and polyvinylpyrrolidone (PVP), wherein the hydrophobic polymer segment comprises wherein R' is -H or -CH
3 , wherein R is -NR
1 R
2 , wherein R
1 and R
2 are alkyl groups, wherein R
1 and R
2 are the same or different, wherein R
1 and R
2 together have from 5 to 16 carbons, wherein R
1 and R
2 may optionally join to form a ring, wherein n is 1 to about 10, and wherein x is about 20 to about 200 in total. Also provided are pH-sensitive micelle compositions for therapeutic and diagnostic applications.摘要翻译： 本文提供了包含亲水性聚合物链段和疏水性聚合物链段的嵌段共聚物，其中所述亲水聚合物链段包含选自以下的聚合物：聚（环氧乙烷）（PEO），聚（甲基丙烯酸酯磷脂酰胆碱）（MPC） 和聚乙烯吡咯烷酮（PVP），其中疏水性聚合物链段包含其中R'是-H或-CH 3，其中R是-NR 1 R 2，其中R 1和R 2是烷基，其中R 1和R 2是 相同或不同，其中R 1和R 2一起具有5至16个碳，其中R 1和R 2可任选地连接形成环，其中n为1至约10，并且其中x为约20至约200 总。 还提供了用于治疗和诊断应用的pH敏感性胶束组合物。
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公开(公告)号：EP3942061A1
公开(公告)日：2022-01-26
申请号：EP20773832.9
申请日：2020-03-18
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , Indiana University Research & Technology Corporation , THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
发明人： FU, Yang-Xin , HUANG, Xiumei , BOOTHMAN, David , HERGENROTHER, Paul, J. , LI, Xiaoguang , JIANG, Lingxiang
IPC分类号： C12Q1/68
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3.发明授权
公开(公告)号：EP2619238B1
公开(公告)日：2017-03-08
申请号：EP11827074.3
申请日：2011-08-11
发明人： GAO, Jinming , BOOTHMAN, David , ZHOU, Kejin , HUANG, Xiaonan , WANG, Yiguang
IPC分类号： C08F293/00 , A61K31/79 , A61K47/62 , A61K49/00 , G01N21/64
CPC分类号： C08F293/005 , A61K9/1075 , A61K9/1273 , A61K9/5031 , A61K31/337 , A61K31/352 , A61K31/704 , A61K47/58 , A61K47/62 , A61K47/6811 , A61K47/6845 , A61K49/0032 , A61K49/005 , A61K49/0054 , A61K49/0056 , A61K49/0082 , C07D311/92 , C08F220/34 , C08F2438/01
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公开(公告)号：EP2619331B1
公开(公告)日：2018-02-28
申请号：EP11827555.1
申请日：2011-09-22
发明人： BOOTHMAN, David , GAO, Jinming , BEY, Erik , DONG, Ying
CPC分类号： C12Q1/6886 , A61K31/00 , A61K31/352 , A61K31/357 , A61K31/4025 , A61K31/423 , A61K31/538 , A61K45/06 , A61N5/10 , C12Q1/26 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , A61K2300/00
摘要： Disclosed herein are methods for determining whether an individual with cancer is suitable for a treatment with an NQO1 bioactivatable drug, predicting responsiveness of an individual with cancer to a treatment with an NQO1 bioactivatable drug, and treating an individual with cancer with an NQO1 bioactivatable drug composition.
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公开(公告)号：EP2619331A1
公开(公告)日：2013-07-31
申请号：EP11827555.1
申请日：2011-09-22
发明人： BOOTHMAN, David , GAO, Jinming , BEY, Erik , DONG, Ying
CPC分类号： C12Q1/6886 , A61K31/00 , A61K31/352 , A61K31/357 , A61K31/4025 , A61K31/423 , A61K31/538 , A61K45/06 , A61N5/10 , C12Q1/26 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , A61K2300/00
摘要： Disclosed herein are methods for determining whether an individual with cancer is suitable for a treatment with an NQOl bioactivatable drug, predicting responsiveness of an individual with cancer to a treatment with an NQOl bioactivatable drug, and treating an individual with cancer with an NQOl bioactivatable drug composition.
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