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公开(公告)号：EP3297623B1
公开(公告)日：2020-10-28
申请号：EP16796931.0
申请日：2016-05-05
发明人： KELLEY, Mark R. , FISHEL, Melissa
IPC分类号： A61K31/192 , A61K31/519 , A61K31/63 , A61K45/06 , A61K31/00 , A61K31/122 , A61P35/00
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公开(公告)号：EP3696881A1
公开(公告)日：2020-08-19
申请号：EP20160559.9
申请日：2012-05-17
发明人： XIE, Jian
IPC分类号： H01M2/18 , H01M2/16 , H01M10/052 , B82Y30/00 , H01M4/1395 , H01M10/0566
摘要： A device for extending the life of a battery, including an electrode having a metal portion, wherein the metal portion is selected from the group including lithium, calcium, magnesium, sodium, potassium and combinations thereof, an electrolyte permeable membrane, and a metal dendrite seeding material disposed between the electrode and the membrane. The electrode, the membrane and the metal dendrite seeding material are positioned in an electrolyte matrix. At least one dendrite extends from the electrode toward the electrolyte permeable membrane combines with at least one dendrite extending from the dendrite seeding material.
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公开(公告)号：EP3367467B1
公开(公告)日：2020-03-04
申请号：EP17203731.9
申请日：2012-05-17
发明人： XIE, Jian
IPC分类号： H01M2/18 , H01M2/16 , H01M10/052 , B82Y30/00 , H01M4/1395 , H01M10/0566
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公开(公告)号：EP3520860A1
公开(公告)日：2019-08-07
申请号：EP19156166.1
申请日：2012-05-25
IPC分类号： A61P35/00 , C07D295/12 , A61K31/4412 , A61K31/496 , A61K31/5377 , C07D295/192 , C07D295/185
摘要： The invention described herein pertains to compounds and compositions for treating Ape1 mediated diseases. In particular, the invention described herein pertains to quinone compounds and pharmaceutical compositions containing them for treating Ape1 mediated diseases.
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公开(公告)号：EP3380194A1
公开(公告)日：2018-10-03
申请号：EP16869113.7
申请日：2016-11-18
CPC分类号： A61K31/353 , A61K31/335 , A61K31/343 , A61K39/39541 , A61K2039/505 , A61P27/02
摘要： Compositions including the combination of cremastranone analogs and anti-angiogenic agents and the use of the compositions for targeting ocular angiogenesis such as seen in neovascular eye diseases are disclosed.
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公开(公告)号：EP2672266B1
公开(公告)日：2018-08-01
申请号：EP13175642.1
申请日：2007-01-13
IPC分类号： G01N33/00 , G01N33/566 , G01N33/567 , G01N33/564 , G01N33/68
CPC分类号： G01N33/564 , G01N33/6887 , G01N2800/12
摘要： Various embodiments include methods for diagnosing and treating medical conditions that involve an autoimmune response to connective tissue such as collagen found in organs such as the lung. In one method pulmonary disease and disorders such as Idiopathic Pulmonary Fibrosis (IPF) are diagnosed by analyzing fluid or tissue samples obtained from a patient for evidence of an autoimmune response to various types of collagen including, for example, Type V. One type of assay for evidence of an autoimmune response to Type V collagen comprises the steps of obtaining a fluid or tissue sample from a patient, contacting at least a portion of the sample with antigen to anti-Type V collagen antibody and monitoring the mixture of sample and antigen for changes indicative of the presence of anti-Type V collagen in the sample. Another embodiment includes treating pulmonary diseases such as IPF by administering a therapeutically effective dose of epitopes of various collagens including Type V collagen.
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公开(公告)号：EP3313176A1
公开(公告)日：2018-05-02
申请号：EP16815387.2
申请日：2016-06-24
IPC分类号： A01K67/027 , A61K35/407 , C12N9/26 , C12N9/40 , C12N15/85 , C12N15/877
CPC分类号： A01K67/0275 , A01K2207/15 , A01K2217/075 , A01K2227/108 , A01K2267/025 , A61K35/407 , A61K35/44 , C07K14/705 , C12N15/8509 , C12N15/877
摘要： The application provides methods of improving a rejection related symptom, reducing premature separation and methods of producing a compound of interest with an altered epitope profile are provided. Transgenic pigs with a disrupted gene or genes, and porcine organs, tissues, and cells therefrom are provided.
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公开(公告)号：EP3206710A1
公开(公告)日：2017-08-23
申请号：EP15845481.9
申请日：2015-09-23
IPC分类号： A61K38/28
CPC分类号： A61K38/22 , A61K9/0019 , A61K9/0024 , A61K38/00 , A61K38/28 , A61K47/02 , A61K47/545 , A61K47/64 , C07K2/00 , C07K14/575 , C07K14/605 , C07K14/62
摘要： Disclosed herein are insulin agonist peptides conjugated to incretins wherein the incretin-insulin conjugate has agonist activity at the insulin receptor and the corresponding incretin receptor, and stimulates weight loss in an individual administered the compound.
摘要翻译： 本文公开了与肠降血糖素缀合的胰岛素激动剂肽，其中肠降血糖素 - 胰岛素缀合物对胰岛素受体和相应的肠降血糖素受体具有激动剂活性，并且刺激施用化合物的个体体重减轻。
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10.发明公开
公开(公告)号：EP3154441A1
公开(公告)日：2017-04-19
申请号：EP15807486.4
申请日：2015-06-10
IPC分类号： A61B10/02
CPC分类号： A61B10/0266 , A61B17/3205 , A61B17/3211 , A61B17/34 , A61B2017/00761 , A61B2017/320052 , A61B2017/320064 , A61B2090/036
摘要： A method and apparatus for extracting tissue samples are disclosed herein. An example apparatus disclosed herein includes a first sidewall and a second sidewall spaced apart from the first sidewall. The example apparatus also includes a track to receive a blade between the first sidewall and the second sidewall. The track is to guide the blade to penetrate skin of a patient to a predetermined depth of invasion.
摘要翻译： 本文公开了一种用于提取组织样本的方法和装置。 本文公开的示例性装置包括与第一侧壁间隔开的第一侧壁和第二侧壁。 示例性装置还包括用于在第一侧壁和第二侧壁之间接收叶片的轨道。 轨迹是引导刀片将患者的皮肤穿透到预定的入侵深度。
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