公开(公告)号：EP3473271A1

公开(公告)日：2019-04-24

申请号：EP18209632.1

申请日：2015-07-31

申请人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services ,  The Hong Kong University of Science and Technology

发明人： FU, Kit Yu ,  FU, Wing Yu ,  DIMITROV, Dimiter S. ,  YING, Tianlei ,  IP, Nancy Yuk-Yu

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61P25/28 ,  A61P35/00

摘要： The present invention provides new, fully human EphA4 monoclonal antibodies with distinct binding characteristics. Also disclosed are antigen binding fragments of these antibodies, bispecific forms of these antibodies, and conjugates of these antibodies. In addition, nucleic acids encoding these antibodies, antigen binding fragments, bispecific antibodies and conjugates are disclosed. These monoclonal antibodies, antigen binding fragments, bispecific antibodies, conjugates, nucleic acids and vectors are of use for identifying and treating a subject with a disease or condition involving abnormal EphA4-mediated signaling.

公开(公告)号：EP3177320A1

公开(公告)日：2017-06-14

申请号：EP15827008.2

申请日：2015-07-31

申请人： The Government of the United States of America as represented by the Secretary of the Department of Health and Human Services ,  The Hong Kong University of Science and Technology

发明人： IP, Nancy Yuk-Yu ,  FU, Kit Yu ,  FU, Wing Yu ,  DIMITROV, Dimiter S. ,  YING, Tianlei

IPC分类号： A61K39/395

CPC分类号： C07K16/2866 ,  A61K39/39558 ,  C07K14/71 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/76 ,  C07K2319/30 ,  G01N33/57492 ,  G01N33/6896 ,  G01N2800/52

摘要： The present invention provides new, fully human EphA4 monoclonal antibodies with distinct binding characteristics. Also disclosed are antigen binding fragments of these antibodies, bispecific forms of these antibodies, and conjugates of these antibodies. In addition, nucleic acids encoding these antibodies, antigen binding fragments, bispecific antibodies and conjugates are disclosed. These monoclonal antibodies, antigen binding fragments, bispecific antibodies, conjugates, nucleic acids and vectors are of use for identifying and treating a subject with a disease or condition involving abnormal EphA4-mediated signaling.

摘要翻译： 本发明提供具有不同结合特征的新的完全人EphA4单克隆抗体。 还公开了这些抗体的抗原结合片段，这些抗体的双特异性形式以及这些抗体的缀合物。 另外，公开了编码这些抗体，抗原结合片段，双特异性抗体和缀合物的核酸。 这些单克隆抗体，抗原结合片段，双特异性抗体，缀合物，核酸和载体可用于鉴定和治疗患有涉及异常EphA4介导的信号传导的疾病或病症的受试者。

公开(公告)号：EP3022206A1

公开(公告)日：2016-05-25

申请号：EP14826591.1

申请日：2014-07-17

申请人： The Hong Kong University of Science and Technology

发明人： IP, Nancy Yuk Yu ,  FU, Kit Yu ,  IP, Fanny Chui Fun ,  FU, Wing Yu ,  GU, Shuo ,  HUANG, Xuhui ,  HUNG, Kwok Wang

IPC分类号： C07D471/20 ,  A61K31/437 ,  A61P25/28

CPC分类号： A61K31/438 ,  A61K31/352 ,  A61K31/402 ,  A61K31/403 ,  A61K31/407 ,  A61K31/437 ,  C07D471/20

摘要： Provided is the discovery of the role of EphA4 signaling in neurodegenerative disorders involving β-amyloid induced neurotoxicity such as Alzheimer's Disease. New therapeutic methods, therapeutic agents, and kits for treating diseases caused or exacerbated by overactivated EphA4 signaling are provided. Also provided are methods for identifying additional compounds as therapeutic agents useful for treating conditions involving overly active EphA4 signaling.

摘要翻译： 提供EphA4信号在涉及淀粉样蛋白诱导的神经毒性如神经退行性疾病如阿尔茨海默病中的作用的发现。 提供了用于治疗由过度活化的EphA4信号传导引起或加剧的疾病的新的治疗方法，治疗剂和试剂盒。 还提供了用于鉴定另外的化合物作为治疗剂的方法，所述治疗剂可用于治疗涉及过度活跃的EphA4信号传导的病症。