公开(公告)号：EP2857830A1

公开(公告)日：2015-04-08

申请号：EP13797296.4

申请日：2013-05-29

申请人： The University of Tokyo

发明人： URANO, Yasuteru ,  SAKABE, Masayo ,  NAGANO, Tetsuo ,  ISHIZAWA, Takeaki ,  YAMASHITA, Suguru ,  KOKUDO, Norihiro ,  KAMIYA, Mako

IPC分类号： G01N21/78 ,  C07D493/10 ,  C09K11/06 ,  C12M1/00 ,  C12M1/34 ,  C12Q1/37 ,  C12Q1/48 ,  G01N21/64 ,  C09B11/28

CPC分类号： C12Q1/37 ,  A61K49/0041 ,  A61K49/006 ,  C07D493/10 ,  C09B11/24 ,  C09K11/06 ,  C09K2211/1007 ,  C09K2211/1011 ,  C09K2211/1088 ,  C12Q1/48

摘要： [Problem]
To provide a fluorescent probe capable of rapidly detecting and imaging with high sensitivity the presence of leakage of pancreatic fluid during or after surgery, and to furthermore provide a detection method and detection kit that use the fluorescent probe.
[Solution]
A fluorescent probe for detecting pancreatic fluid containing a compound or salt thereof represented by formula (I) below.

(In the formula, A represents an amino acid residue or N-substituted amino acid residue, with A forming an amide bond with the adjacent NH in the formula; R 1 represents a hydrogen atom or 1 to 4 same or different substituent groups that bond with a benzene ring; R 2 , R 3 , R 4 , R 5 , R 6 , and R 7 each independently represent a hydrogen atom, a hydroxyl group, an alkyl group, or a halogen atom; R 8 and R 9 each independently represent a hydrogen atom or an alkyl group; and X represents a C 1 -C 3 alkylene group.)

摘要翻译： 本发明的目的在于提供一种能够高灵敏度地快速检测手术期间或手术后的胰液的泄漏的荧光探针，并且还提供使用荧光探针的检测方法和检测试剂盒。 用于检测含有由下式（I）表示的化合物或其盐的胰液的荧光探针。 （式中，A表示氨基酸残基或N-取代氨基酸残基，其中A与式中相邻的NH形成酰胺键; R 1表示氢原子或1至4个相同或不同的与 苯环; R 2，R 3，R 4，R 5，R 6和R 7各自独立地表示氢原子，羟基，烷基或卤素原子; R 8和R 9各自独立地表示氢原子或烷基; X表示碳原子数1〜3的亚烷基。）