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公开(公告)号：EP3099678B1
公开(公告)日：2018-12-12
申请号：EP15705859.5
申请日：2015-01-29
发明人： FLEURY, Melissa , BEAUSOLIEL, Anne-Marie , HUGHES, Adam D. , LONG, Daniel D. , WILTON, Donna A.A.
IPC分类号： C07D405/14 , C07D309/40 , C07C271/22 , C07D319/06 , C07D231/20 , C07D233/70 , C07D233/90 , C07D401/04 , C07D235/08 , C07D403/06 , C07D237/14 , C07D239/34 , C07D405/12 , C07C229/34 , C07D249/12 , C07D249/18 , C07D471/04 , A61P9/04 , A61P13/12 , A61P9/12
CPC分类号： C07D249/04 , A61K31/415 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/437 , A61K31/44 , A61K31/4985 , A61K31/505 , A61K45/06 , A61P9/04 , A61P9/12 , A61P13/12 , C07C229/34 , C07C271/22 , C07D213/81 , C07D231/14 , C07D231/18 , C07D231/20 , C07D233/70 , C07D233/90 , C07D235/08 , C07D237/14 , C07D239/28 , C07D239/34 , C07D249/10 , C07D249/12 , C07D249/18 , C07D261/12 , C07D261/18 , C07D263/18 , C07D263/34 , C07D263/38 , C07D271/07 , C07D275/03 , C07D295/10 , C07D309/40 , C07D319/06 , C07D401/04 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04
摘要： In one aspect, the invention relates to compounds having the formula I: where R1-R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
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公开(公告)号：EP3099678A1
公开(公告)日：2016-12-07
申请号：EP15705859.5
申请日：2015-01-29
发明人： FLEURY, Melissa , BEAUSOLIEL, Anne-Marie , HUGHES, Adam D. , LONG, Daniel D. , WILTON, Donna A.A.
IPC分类号： C07D405/14 , C07D309/40 , C07C271/22 , C07D319/06 , C07D231/14 , C07D231/18 , C07D231/20 , C07D233/70 , C07D233/90 , C07D401/04 , C07D235/08 , C07D403/06 , C07D237/14 , C07D239/34 , C07D405/12 , C07C229/34 , C07D249/10 , C07D249/12 , C07D249/18 , C07D471/04
CPC分类号： C07D249/04 , A61K31/415 , A61K31/4192 , A61K31/4196 , A61K31/42 , A61K31/421 , A61K31/4245 , A61K31/425 , A61K31/437 , A61K31/44 , A61K31/4985 , A61K31/505 , A61K45/06 , A61P9/04 , A61P9/12 , A61P13/12 , C07C229/34 , C07C271/22 , C07D213/81 , C07D231/14 , C07D231/18 , C07D231/20 , C07D233/70 , C07D233/90 , C07D235/08 , C07D237/14 , C07D239/28 , C07D239/34 , C07D249/10 , C07D249/12 , C07D249/18 , C07D261/12 , C07D261/18 , C07D263/18 , C07D263/34 , C07D263/38 , C07D271/07 , C07D275/03 , C07D295/10 , C07D309/40 , C07D319/06 , C07D401/04 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D471/04
摘要： In one aspect, the invention relates to compounds having the formula I: where R1-R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
摘要翻译： 其中R 1 -R 6如说明书中所定义，或其药学上可接受的盐。 这些化合物具有尿丙氨酸抑制活性。 另一方面，本发明涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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3.发明公开5-BIPHENYL-4-HETEROARYLCARBONYLAMINO-PENTANOIC ACID DERIVATIVES AS NEPRILYSIN INHIBITORS 审中-公开5-联苯-4-邻苯二甲酰亚胺 - 戊二酸二乙酯NEPRILYSININHIBITOREN
公开(公告)号：EP3099668A1
公开(公告)日：2016-12-07
申请号：EP15705153.3
申请日：2015-01-29
发明人： FLEURY, Melissa , BEAUSOLIEL, Anne-Marie , HUGHES, Adam D. , LONG, Daniel D. , WILTON, Donna A.A.
IPC分类号： C07D249/04 , C07D231/14 , C07D271/07 , C07D261/10 , C07D213/56 , C07D239/42 , C07D249/14 , A61K31/4192 , A61K31/4196 , A61K31/415 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K31/505 , A61P9/00
CPC分类号： A61K31/505 , A61K31/415 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/4245 , A61K31/44 , A61K45/06 , C07C229/08 , C07C271/22 , C07D207/16 , C07D213/56 , C07D213/81 , C07D231/14 , C07D239/28 , C07D239/42 , C07D249/04 , C07D249/10 , C07D249/14 , C07D261/10 , C07D263/34 , C07D271/07 , C07D307/24 , C07D403/12 , C07D405/12
摘要： In one aspect, the invention relates to compounds having the formula I: where R1, R2a, R2b, and R3-R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
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