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1.发明公开PALLADIUM CATALYZED ALKYLATIVE CYCLIZATION USEFUL IN SYNTHESIS OF VITAMIN D AND ANALOGUES. 失效钯催化的烷基化环化使用含维生素D及其类似物的合成适用于您。
公开(公告)号：EP0630361A4
公开(公告)日：1995-08-23
申请号：EP93904940
申请日：1993-02-05
发明人： TROST BARRY M , DUMAS JACQUES
IPC分类号： B01J31/18 , B01J31/24 , C07B37/04 , C07B37/10 , C07B61/00 , C07C2/86 , C07C13/465 , C07C17/26 , C07C17/272 , C07C22/00 , C07C23/18 , C07C29/44 , C07C33/44 , C07C35/21 , C07C41/30 , C07C43/178 , C07C401/00 , C07F7/18 , C07C13/36 , C07C13/38 , C07C403/00 , C07C403/02
CPC分类号： C07F7/1892 , C07B37/10 , C07C17/2635 , C07C22/00 , C07C33/44 , C07C35/21 , C07C401/00 , Y02P20/55
摘要： An alkylative cycloaddition method is provided that is particularly useful for the synthesis of many of the Vitamin D analogues with differing side chains. Thus, a preferred synthesis is of Vitamin D analogues having a side chain R1 where a substantially geometrically pure first precursor having structure (I), and a second precursor are provided, the second precursor being a 1,7 enyne. These precursors are reacted in the presence of a palladium catalyst to form compounds having structure (II), where R2 is hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group, and R3 is hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group.
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2.发明公开ASYMMETRIC LIGANDS USEFUL FOR TRANSITION METAL CATALYZED BOND FORMING REACTIONS AND EPOXIDE REACTIONS THEREWITH 失效不对称配体的使用过渡金属，KATLYSIERTEN合成及相关EPOXIDREAKTIONEN
公开(公告)号：EP0782577A4
公开(公告)日：1998-01-07
申请号：EP95935015
申请日：1995-09-11
发明人： TROST BARRY M , BUNT RICHARD C
IPC分类号： C07D263/26 , B01J31/24 , C07C213/04 , C07C227/12 , C07D207/40 , C07D207/416 , C07D209/48 , C07F9/50 , C07F9/553 , C07F9/655 , C22B3/38
CPC分类号： C07F9/5537 , B01J31/189 , B01J31/2208 , B01J31/2409 , B01J31/2414 , B01J31/2452 , B01J31/2457 , B01J2531/0258 , B01J2531/824 , C07C213/04 , C07C227/12 , C07D207/416 , C07F9/5022 , C07F9/65515 , C07F9/6552 , C22B3/005 , Y02P10/234
摘要： A novel ligand having formula (1) structure has proved remarkably successful in the amination of butadiene monoepoxide, which is a potentially desirable substrate for an asymmetric synthesis providing access to each enantiomer of vinylglycinol. This and other ligands described are useful for chiral induction of bond forming reactions with an epoxide substrate.
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3.发明公开PALLADIUM CATALYZED ALKYLATIVE CYCLIZATION USEFUL IN SYNTHESES OF VITAMIN D AND ANALOGUES 失效钯催化的烷基化环化合成维生素D及其衍生物的
公开(公告)号：EP0738251A4
公开(公告)日：1997-05-14
申请号：EP95906663
申请日：1994-12-19
发明人： TROST BARRY M , DUMAS JACQUES
IPC分类号： B01J31/24 , C07B37/10 , C07C17/26 , C07C22/00 , C07C401/00 , C07C13/36 , C07C13/38 , C07C403/00
CPC分类号： C07C401/00 , C07B37/10 , C07C17/2635 , C07C22/00 , Y02P20/55
摘要： An alkylative cycloaddition method is provided that is particularly useful for the synthesis of many of the Vitamin D analogues with differing side chains. Thus, a preferred synthesis is of Vitamin D analogues having a side chain R1 where a first precursor having the structure (a), with X being a halide or a pseudo halide, and a second precursor are provided, the second precursor being a 1,7 enyne. These precursors are reacted in the presence of a palladium catalyst to form compounds having structure (1), where R2 is hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group, and R3 is hydrogen, hydroxyl, lower alkoxy, fluorine, or a protecting group.
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