公开(公告)号：EP2417165A1

公开(公告)日：2012-02-15

申请号：EP10761153.5

申请日：2010-04-06

申请人： UNIVERSITY OF SASKATCHEWAN ,  Bioniche Life Sciences Inc.

发明人： POTTER, Andrew, A. ,  ASPER, David ,  ROGAN, Dragan

IPC分类号： C07K19/00 ,  A61K39/108 ,  A61K39/385 ,  A61P31/04 ,  A61P37/04 ,  C07K14/245

CPC分类号： A61K39/0258 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/6037 ,  C07K16/1232 ,  Y02A50/474

摘要： Compositions and methods for stimulating an immune response against Shiga toxin-producing Escherichia coli (STEC) antigens are disclosed. The compositions include a multiple epitope fusion protein comprising more than one epitope of an immunogenic STEC protein from more than one STEC serotype. Additional compositions include at least two purified STEC proteins, wherein the STEC proteins are selected from a full-length STEC protein, an immunogenic fragment or variant thereof, wherein at least one of the STEC proteins generates antibodies that react with STEC O157 and at least one other STEC serotype.

公开(公告)号：EP1292327B1

公开(公告)日：2007-03-21

申请号：EP01944804.2

申请日：2001-06-11

申请人： UNIVERSITY OF SASKATCHEWAN

发明人： POTTER, Andrew, A. ,  BOLTON, Alexandra, J. ,  SONG, Xin, Ming

IPC分类号： A61K39/09 ,  A61K48/00

CPC分类号： C07K14/315 ,  A61K39/00

摘要： The Mig protein gene of Streptococcus dysgalactiae, and the corresponding amino acid sequence, is described, as is the use of the Mig protein in vaccine compositions to prevent and treat bacterial infections in general, and mastitis in particular.

公开(公告)号：EP1332155A2

公开(公告)日：2003-08-06

申请号：EP01949115.8

申请日：2001-06-11

申请人： UNIVERSITY OF SASKATCHEWAN

发明人： BOLTON, Alexandra, J. ,  PEREZ-CASAL, Jose ,  FONTAINE, Michael ,  POTTER, Andrew, A.

IPC分类号： C07K14/315 ,  C12N15/31 ,  C12N15/70 ,  C12N1/21 ,  A61K39/09 ,  C07K16/12 ,  A61P31/04 ,  A61K31/7088 ,  G01N33/569 ,  G01N33/577 ,  G01N33/68

CPC分类号： C07K14/315 ,  A61K39/00 ,  A61K2039/53

摘要： The GapC plasmin binding protein genes of Streptococcus dysgalactiae (S. dysgalactiae), Streptococcus agalactiae (S. agalactiae), Streptococcus uberis (S. uberis), Streptococcus parauberis (S. parauberis), and Streptococcus iniae (S.iniae) are described, as well as the recombinant production of the GapC proteins therefrom. Also described is the use of the GapC proteins from those species in vaccine compositions to prevent or treat bacterial infections in general, and mastitis in particular.

公开(公告)号：EP1037909A2

公开(公告)日：2000-09-27

申请号：EP98959682.0

申请日：1998-12-11

申请人： The University of Saskatchewan

发明人： WANG, Li ,  BABIUK, Lorne, A. ,  POTTER, Andrew, A. ,  WILLSON, Philip

IPC分类号： C07K14/00

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/552 ,  C12N7/00 ,  C12N15/86 ,  C12N2750/10022 ,  C12N2750/10043 ,  C12Q1/701

摘要： The cloning of a novel PCVII viral genome is described as is expression of proteins derived from the PCVII genome. These proteins can be used in vaccine compositions for the prevention and treatment of PCVII infections, as well as in diagnostic methods for determining the presence of PCVII infections in a vertebrate subject. Polynucleotides derived from the viral genome can be used as diagnostic primers and probes.

公开(公告)号：EP0527724B1

公开(公告)日：1997-08-27

申请号：EP90906831.4

申请日：1990-05-25

申请人： The University of Saskatchewan

发明人： ACRES, Stephen, D. ,  BARIUK, Lorne, A. ,  POTTER, Andrew, A. ,  LAWMAN, Michael, J., P.

IPC分类号： A61K39/102 ,  C12N15/31

CPC分类号： A61K39/102 ,  A61K39/00 ,  C07K14/285

摘要： New proteins and subunit antigens from P. haemolytica for use in stimulating immunity against respiratory diseases such as pneumonia, including shipping fever pneumonia, are disclosed. The subunit antigens include immunogenic amino acid sequences of P. haemolytica fimbrial protein, P. haemolytica plasmin receptor protein, and P. haemolytica 50 K outer membrane protein and P. haemolytica leukotoxin. The antigens can be used in a vaccine composition, either alone or in combination. Also disclosed are methods of vaccination as well as methods of making the subunit antigens employed in the vaccines.

公开(公告)号：EP0920510B1

公开(公告)日：2005-07-27

申请号：EP97935395.0

申请日：1997-08-08

申请人： University of Saskatchewan

发明人： POTTER, Andrew, A. ,  MANNS, John, G.

IPC分类号： C12N15/16 ,  C12N15/31 ,  C12N15/62 ,  C12N1/21 ,  C07K14/285 ,  C07K7/23 ,  A61K38/09 ,  A61K39/385

CPC分类号： A61K39/0006 ,  A61K39/00 ,  A61K47/62 ,  A61K47/646 ,  A61K47/6829 ,  A61K47/6833 ,  A61K2039/6037 ,  C07K5/1008 ,  C07K5/1019 ,  C07K5/1021 ,  C07K5/1024 ,  C07K7/23 ,  C07K14/005 ,  C07K14/285 ,  C07K14/655 ,  C07K16/26 ,  C07K2319/00 ,  C12N2720/12322

摘要： New immunological carrier systems, DNA encoding the same, and the use of these systems, are disclosed. The carrier systems include chimeric proteins which include a leukotoxin polypeptide fused to one or more selected GnRH multimers which comprise at least one repeating GnRH decapeptide sequence, or at least one repeating unit of a sequence corresponding to at least one epitope of a selected GnRH molecule. Under the invention, the selected GnRH sequences may all be the same, or may correspond to different derivatives, analogues, variants or epitopes of GnRH so long as the GnRH sequences are capable of eliciting an immune response. The leukotoxin functions to increase the immunogenicity of the GnRH multimers fused thereto.

公开(公告)号：EP1292327A2

公开(公告)日：2003-03-19

申请号：EP01944804.2

申请日：2001-06-11

申请人： UNIVERSITY OF SASKATCHEWAN

发明人： POTTER, Andrew, A. ,  BOLTON, Alexandra, J. ,  SONG, Xin, Ming

IPC分类号： A61K39/09 ,  A61K48/00

CPC分类号： C07K14/315 ,  A61K39/00

摘要： The Mig protein gene of Streptococcus dysgalactiae, and the corresponding amino acid sequence, is described, as is the use of the Mig protein in vaccine compositions to prevent and treat bacterial infections in general, and mastitis in particular.

公开(公告)号：EP1159426A1

公开(公告)日：2001-12-05

申请号：EP00908866.7

申请日：2000-03-10

申请人： The University of Saskatchewan

发明人： POTTER, Andrew, A. ,  RIOUX, Clement ,  SCHRYVERS, Anthony, B.

IPC分类号： C12N15/31 ,  C07K14/285 ,  A61K39/102 ,  G01N33/68

CPC分类号： C07K14/285 ,  A61K39/00

摘要： Cloning and expression of genes encoding H. somnus transferring-binding proteins are described. The transferrin-binding proteins can be used in vaccine compositions for the prevention and treatment of H. somnus infections, as well as in diagnostic methods for determining the presence of H. Somnus infections.

公开(公告)号：EP0527724A1

公开(公告)日：1993-02-24

申请号：EP90906831.0

申请日：1990-05-25

申请人： The University of Saskatchewan

发明人： ACRES, Stephen, D. ,  BARIUK, Lorne, A. ,  POTTER, Andrew, A. ,  LAWMAN, Michael, J., P.

IPC分类号： A61K39 ,  A61P31 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N15 ,  C12P21 ,  C12R1

CPC分类号： A61K39/102 ,  A61K39/00 ,  C07K14/285

摘要： L'invention a pour objet de nouvelles protéines et des antigènes de sous-groupes provenant de P. haemolytica, s'utilisant pour stimuler l'immunité contre des maladies respiratoires comme la pneumonie, y compris la pneumonie causée par le transport. Les antigènes de sous-groupes comprennent des séquences immunogènes amino-acides de la protéine periphérifine de P. haemolytica, de la proteine réceptrice de plasmine de P. haemolytica et de la protéine de membrane extérieure 50 K de P. haemolytica ainsi que de la leucotoxine de P. haemolytica. Les antigènes peuvent s'utiliser dans une composition de vaccin, soit seuls soit en combinaison. L'invention se rapporte également à des procédés de vaccination ainsi qu'à des procédés de production des antigènes de sous-groupes

公开(公告)号：EP1349570B1

公开(公告)日：2013-11-20

申请号：EP02726978.6

申请日：2002-01-03

申请人： UNIVERSITY OF SASKATCHEWAN ,  THE UNIVERSITY OF BRITISH COLUMBIA

发明人： FINLAY, Brett ,  POTTER, Andrew, A.

IPC分类号： A61K39/108 ,  C07K14/245 ,  C12N1/20 ,  A61P31/04 ,  A61K39/39 ,  C07K1/02 ,  C07K1/34

CPC分类号： A61K39/0258 ,  A61K2039/55566 ,  C07K14/245 ,  Y02A50/474

摘要： Compositions and methods for stimulating an immune response against a secreted enterohemorragic Escherichia coli (EHEC) antigen are disclosed. The compositions comprise EHEC cell culture supernatants.