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公开(公告)号：EP2498788B1
公开(公告)日：2019-01-09
申请号：EP10817754.4
申请日：2010-09-15
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公开(公告)号：EP3359968A1
公开(公告)日：2018-08-15
申请号：EP16854163.9
申请日：2016-10-04
CPC分类号： G01N33/5438 , G01N27/327 , G01N33/6887 , G01N2800/32
摘要： The invention relates to ex-situ biosensors that impedimetrically detect cardiac biomarkers of interest in a bodily fluid sample derived from a patient. The biosensors include a multi-array of vertically aligned platinum wires having immobilized thereon an aptamer that is selected to specifically and selectively bind to the cardiac markers of interest. The biosensors are contacted with a portion of the bodily fluid sample, and the aptamer binds to the cardiac markers of interest in the bodily fluid sample. As a result, an electrochemical impedance signal is generated and therefore, a change in electrochemical impedance is indicative of the presence of the cardiac markers of interest in the bodily fluid sample. The biosensors are point-of-care, on-demand devices that can be used in a medical environment, as well as in domestic settings.
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公开(公告)号：EP2764130B1
公开(公告)日：2019-03-06
申请号：EP12838640.6
申请日：2012-10-05
发明人： KUMTA, Prashant N. , CHOU, Da-Tren , HONG, Daeho , SAHA, Partha
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5.发明公开
公开(公告)号：EP2498788A2
公开(公告)日：2012-09-19
申请号：EP10817754.4
申请日：2010-09-15
CPC分类号： A61L24/02 , A61K33/06 , A61K33/08 , A61K33/42 , A61K45/06 , A61L24/0036 , A61L2400/06 , A61L2430/02 , B33Y70/00 , B33Y80/00 , A61K2300/00
摘要： The present invention relates to bone substitute compositions and methods of their preparation, and their use in a wide variety of clinical applications. The compositions include calcium phosphate, acidic calcium salt, basic calcium salt, sodium hydrogen phosphate and porogen. The compositions further include a mixing liquid. The compositions can optionally include biological signaling molecules and/or a growth compound. Further, the compositions can optionally include a plasticizer.
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公开(公告)号：EP4328343A3
公开(公告)日：2024-08-21
申请号：EP24150562.7
申请日：2018-04-12
发明人： KUMTA, Prashant N.
CPC分类号： A61L27/047 , A61L27/58 , C22C23/04 , A61L31/148 , A61L31/022 , C22C23/06
摘要： The invention relates to biodegradable, metal alloys, methods for their preparation and applications for their use. The alloys include magnesium and other components, such as, yttrium, calcium, zirconium, and zinc. These elements are alloyed together in specific combinations and amounts in order to achieve an alloy having desired properties and characteristics. In certain embodiments, strontium or cerium may be included as an additive. The resulting alloys are particularly suitable for forming various medical devices for implantation into the body of a patient.
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公开(公告)号：EP3736563A1
公开(公告)日：2020-11-11
申请号：EP20183546.9
申请日：2016-10-04
IPC分类号： G01N27/04 , G01N33/543 , C12Q1/68 , G01N33/68 , G01N33/558
摘要： The invention relates to a portable handheld device for detecting the presence of cardiac biomarkers in a sample of bodily fluid, comprising a test strip comprising an aptamer capable of binding to a cardiac biomarker when the test strip is contacted with a sample of bodily fluid from a patient;
wherein the test strip is configured to provide a visual change based on its contact with the sample of bodily fluid; wherein the presence of a visual change is indicative of binding of the aptamer in the test strip with a cardiac biomarker in the sample of bodily fluid from the patient; and wherein the device further comprises a standard chart or key for interpreting a visual change on the test strip. The cardiac biomarkers can be selected from C-reactive protein, Creatinine Kinase, TroponinT, Myoglobin, IL-6, IL-18, Brain Natriuretic Peptide, and D-Dimer.-
公开(公告)号：EP3359968B1
公开(公告)日：2020-08-19
申请号：EP16854163.9
申请日：2016-10-04
IPC分类号： G01N27/04 , G01N33/543 , C12Q1/68 , G01N33/68
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公开(公告)号：EP2764130A2
公开(公告)日：2014-08-13
申请号：EP12838640.6
申请日：2012-10-05
发明人： KUMTA, Prashant N. , CHOU, Da-Tren , HONG, Daeho , SAHA, Partha
CPC分类号： A61F2/02 , A61K31/397 , A61K31/7036 , A61L27/047 , A61L27/58 , C22C1/02 , C22C23/00 , C22C23/04 , C22C23/06 , C22F1/06
摘要： The invention relates to biodegradable, metal alloy-containing compositions, methods for their preparation and applications for their use. The compositions include magnesium and other components, such as yttrium, calcium, silver, cerium, and zirconium; or zinc, silver, cerium, and zirconium; or aluminum, zinc, calcium, manganese, silver, yttrium; or strontium, calcium, zinc. The compositions are prepared by vacuum induction/crucible melting together the components and casting the melted mixture in a preheated mild steel/copper mold. In certain embodiments, the compositions of the invention are particularly useful for forming medical devices for implantation into a body of a patient.
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公开(公告)号：EP4328343A2
公开(公告)日：2024-02-28
申请号：EP24150562.7
申请日：2018-04-12
发明人： KUMTA, Prashant N.
IPC分类号： C22C23/00
摘要： The invention relates to biodegradable, metal alloys, methods for their preparation and applications for their use. The alloys include magnesium and other components, such as, yttrium, calcium, zirconium, and zinc. These elements are alloyed together in specific combinations and amounts in order to achieve an alloy having desired properties and characteristics. In certain embodiments, strontium or cerium may be included as an additive. The resulting alloys are particularly suitable for forming various medical devices for implantation into the body of a patient.
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