公开(公告)号：EP1879859A2

公开(公告)日：2008-01-23

申请号：EP06770422.1

申请日：2006-05-12

申请人： Wyeth

发明人： GOPALSAMY, Ariamala ,  MOORE, William, Jay ,  KERN, Jeffery, Curtis ,  MOLINARI, Albert, John ,  SHI, Mengxiao ,  WELMAKER, Gregory, Scott ,  WILSON, Matthew, Allan ,  KRISHNAMURTHY, Girija ,  COMMONS, Thomas, Joseph ,  WEBB, Michael, Byron ,  WOODWORTH, Richard, P.

IPC分类号： C07C317/20 ,  C07C317/22 ,  C07C317/26 ,  C07C317/38 ,  A61K31/445

CPC分类号： C07F9/3882 ,  C07C317/14 ,  C07C317/22 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07D213/42 ,  C07D233/54 ,  C07D401/04 ,  C07F9/4056

摘要： Compounds of Formula (I), or pharmaceutically acceptable salts thereof, are provided, which are modulators of secreted frizzled related protein-1. The compounds, and compositions containing the compounds, can be used to treat a variety of disorders, including osteoporosis.

摘要翻译： 提供式1化合物或其药学上可接受的盐：其是分泌的卷曲相关蛋白-1的调节剂。 化合物和含有这些化合物的组合物可用于治疗多种疾病，包括骨质疏松症。

公开(公告)号：EP1242822B1

公开(公告)日：2008-06-25

申请号：EP00980905.4

申请日：2000-12-01

申请人： Wyeth Holdings Corporation

发明人： KRISHNAMURTHY, Girija

IPC分类号： G01N33/68

CPC分类号： G01N33/6896 ,  G01N2333/4709 ,  G01N2800/2821

摘要： A method/assay for detecting various aggregated forms of amyloid peptide using amyloid-specific spectroscopic probes, such as Congo red and related analogs, is described. Such an assay could be used to assess the aggregation state of the peptide in the presence of other potential inhibitors of fibrillogenesis, providing a useful model by which to test inhibitors of aggregation in in vitro models. Results of such an assay can be useful in determining the stage at which the process of aggregation can be intervened to reduce the toxicity of amyloid peptide to neuronal cells. In specific examples, circular dichroism, UV absorption, and fluorescence spectroscopy are each used to evaluate the aggregation form of beta -amyloid peptide.