公开(公告)号：EP1879859A2

公开(公告)日：2008-01-23

申请号：EP06770422.1

申请日：2006-05-12

申请人： Wyeth

发明人： GOPALSAMY, Ariamala ,  MOORE, William, Jay ,  KERN, Jeffery, Curtis ,  MOLINARI, Albert, John ,  SHI, Mengxiao ,  WELMAKER, Gregory, Scott ,  WILSON, Matthew, Allan ,  KRISHNAMURTHY, Girija ,  COMMONS, Thomas, Joseph ,  WEBB, Michael, Byron ,  WOODWORTH, Richard, P.

IPC分类号： C07C317/20 ,  C07C317/22 ,  C07C317/26 ,  C07C317/38 ,  A61K31/445

CPC分类号： C07F9/3882 ,  C07C317/14 ,  C07C317/22 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07D213/42 ,  C07D233/54 ,  C07D401/04 ,  C07F9/4056

摘要： Compounds of Formula (I), or pharmaceutically acceptable salts thereof, are provided, which are modulators of secreted frizzled related protein-1. The compounds, and compositions containing the compounds, can be used to treat a variety of disorders, including osteoporosis.

摘要翻译： 提供式1化合物或其药学上可接受的盐：其是分泌的卷曲相关蛋白-1的调节剂。 化合物和含有这些化合物的组合物可用于治疗多种疾病，包括骨质疏松症。

公开(公告)号：EP2054410A2

公开(公告)日：2009-05-06

申请号：EP07836789.3

申请日：2007-08-13

申请人： Wyeth

发明人： COMMONS, Thomas, Joseph ,  FENSOME, Andrew ,  HEFFERNAN, Gavin, David ,  MCCOMAS, Casey, Cameron ,  WOODWORTH, Richard, Page, Jr. ,  WEBB, Michael, Byron ,  MARELLA, Michael, Anthony ,  MELENSKI, Edward, George ,  BERNOTAS, Ronald, Charles

IPC分类号： C07D417/04

CPC分类号： C07D417/04 ,  C07D263/48 ,  C07D413/04 ,  C07D417/14 ,  C07D453/06

摘要： Compounds of the structure (I) are described, wherein R1, R2, R5, R6, V, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compounds are useful for treating a variety of hormone-related conditions including contraception, treating or preventing fibroids, endometriosis, dysfunctional bleeding, uterine leiomyomata, polycystic ovary syndrome, or hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake or synchronizing estrus.

公开(公告)号：EP1537122A1

公开(公告)日：2005-06-08

申请号：EP03754498.8

申请日：2003-09-11

申请人： Wyeth

发明人： STACK, Gary, Paul ,  WEBB, Michael, Byron ,  EVRARD, Deborah, Ann ,  ZHOU, Dahui

IPC分类号： C07D491/04 ,  C07D498/04 ,  A61K31/436 ,  A61P25/00

CPC分类号： C07D491/04

摘要： Compounds of the Formula: are useful for the treatment of depression ( including but not limited to major depressive disorder, childhood depression and dysthymia). Anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder ( with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

摘要翻译： 式的化合物可用于治疗抑郁症（包括但不限于重度抑郁症，儿童期抑郁症和精神抑郁症）。 焦虑症，恐慌症，创伤后应激障碍，经前烦躁症（也称为经前期综合征），注意力缺陷障碍（有和没有过度活跃），强迫症，社交焦虑症，广泛性焦虑症，肥胖症， 神经性厌食症，神经性贪食症，血管舒缩潮红，可卡因和酒精成瘾，性功能障碍和相关疾病。

公开(公告)号：EP1537122B9

公开(公告)日：2007-10-31

申请号：EP03754498.8

申请日：2003-09-11

申请人： Wyeth

发明人： STACK, Gary, Paul ,  WEBB, Michael, Byron ,  EVRARD, Deborah, Ann ,  ZHOU, Dahui

IPC分类号： C07D491/04 ,  C07D498/04 ,  A61K31/436 ,  A61P25/00

CPC分类号： C07D491/04

摘要： Compounds of the Formula: are useful for the treatment of depression ( including but not limited to major depressive disorder, childhood depression and dysthymia). Anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder ( with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.

公开(公告)号：EP1537122B1

公开(公告)日：2007-08-22

申请号：EP03754498.8

申请日：2003-09-11

申请人： Wyeth

发明人： STACK, Gary, Paul ,  WEBB, Michael, Byron ,  EVRARD, Deborah, Ann ,  ZHOU, Dahui

IPC分类号： C07D491/04 ,  C07D498/04 ,  A61K31/436 ,  A61P25/00

CPC分类号： C07D491/04

摘要： Compounds of the Formula: are useful for the treatment of depression ( including but not limited to major depressive disorder, childhood depression and dysthymia). Anxiety, panic disorder, post-traumatic stress disorder, premenstrual dysphoric disorder (also known as premenstrual syndrome), attention deficit disorder ( with and without hyperactivity), obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, obesity, eating disorders such as anorexia nervosa, bulimia nervosa, vasomotor flushing, cocaine and alcohol addiction, sexual dysfunction and related illnesses.