公开(公告)号：EP3587448A1

公开(公告)日：2020-01-01

申请号：EP19175124.7

申请日：2014-03-17

申请人： Xencor, Inc.

发明人： MOORE, Gregory ,  DESJARLAIS, John ,  RASHID, Rumana ,  BERNETT, Matthew J.

IPC分类号： C07K16/06 ,  C07K16/28 ,  C07K16/46

摘要： In one aspect, the present invention provides heterodimeric antibodies comprising a first monomer comprising a first heavy chain constant domain comprising a first variant Fc domain and a first antigen binding domain and a second monomer comprising a second heavy chain constant domain comprising a second variant Fc domain and a second antigen binding domain. In an additional aspect the heterodimeric antibody comprises a first monomer comprising a heavy chain comprising a first Fc domain and a single chain Fv region (scFv) that binds a first antigen, wherein the scFv comprises a charged scFv linker. The heterodimeric antibody further comprises a second monomer comprising a first heavy chain comprising a second Fc domain and a first variable heavy chain and a first light chain.

公开(公告)号：EP2943511A1

公开(公告)日：2015-11-18

申请号：EP14738267.5

申请日：2014-01-14

申请人： Xencor, Inc.

发明人： DESJARLAIS, John ,  MOORE, Gregory ,  RASHID, Rumana ,  BERNETT, Matthew J.

IPC分类号： C07K16/46

CPC分类号： C07K16/468 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/2896 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/528 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/94

摘要： The invention provides novel heterodimeric proteins including heterodimeric antibodies.

摘要翻译： 本发明提供了包括异二聚体抗体的新型异二聚体蛋白。

公开(公告)号：EP2125893A2

公开(公告)日：2009-12-02

申请号：EP08728147.3

申请日：2008-01-23

申请人： Xencor, Inc.

发明人： BERNETT, Matthew J. ,  CHU, Seung Yup ,  DESJARLAIS, John R. ,  KARKI, Sher Bahadur ,  LAZAR, Gregory Alan ,  PONG, Erik WeiKing ,  ZHUKOVSKY, Eugene Alexander

IPC分类号： C07K16/28

CPC分类号： C07K16/2878 ,  C07K2317/72 ,  C07K2317/73

摘要： The present invention describes antibodies that target CD40, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an FcyR or alters effector function as compared to the parent antibody. Also disclosed are methods of using the antibodies of the invention.

公开(公告)号：EP2064240A2

公开(公告)日：2009-06-03

申请号：EP07842719.2

申请日：2007-09-18

申请人： Xencor, Inc.

发明人： BERNETT, Matthew J. ,  DESJARLAIS, John R. ,  KARKI, Sher Bahadur ,  LAZAR, Gregory Alan ,  MUCHHAL, Umesh S. ,  NGUYEN, Duc-hanh Thi ,  RICHARDS, John O.

IPC分类号： C07K16/00

CPC分类号： C07K16/2896 ,  A61K31/454 ,  A61K31/573 ,  A61K31/69 ,  A61K39/3955 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/92

摘要： The present disclosure describes antibodies that target HM1.24. In various aspects, the antibodies have specific CDR, variable, or full length sequences, have modifications with the parent antibody, or include at least one one modification relative to a parent antibodythat alters affinity to an FcγR or alters effector function as compared to the parent antibody. Nucleic acids encoding the antibodies and methods of using the antibodies are also disclosed.

公开(公告)号：EP3620473A1

公开(公告)日：2020-03-11

申请号：EP19187150.8

申请日：2014-01-14

申请人： Xencor, Inc.

发明人： DESJARLAIS, John ,  MOORE, Gregory ,  RASHID, Rumana ,  BERNETT, Matthew J.

IPC分类号： C07K16/46

摘要： The invention provides novel heterodimeric proteins including heterodimeric antibodies. The present invention describes novel immunoglobulin compositions that simultaneously co-engage antigens, where both of the antigens are bound monovalently. The novel immunoglobulins described preferably utilize heterodimeric Fe regions. Methods of using the novel immunoglobulin compositions, particularly for therapeutic purposes, are also described herein.

公开(公告)号：EP3611187A1

公开(公告)日：2020-02-19

申请号：EP19186573.2

申请日：2012-10-10

申请人： Xencor, Inc.

发明人： BERNETT, Matthew J. ,  MOORE, Gregory, L. ,  DESJARLAIS, John ,  RASHID, Rumana

IPC分类号： C07K16/00 ,  C07K16/46

摘要： The invention relates generally to compositions and methods for purifying the desired species from a mixture of desired heterodimer and contaminating homodimer immunoglobulin variants by modifying the isoelectric point(s) of the individual chains.

公开(公告)号：EP2943511B1

公开(公告)日：2019-08-07

申请号：EP14738267.5

申请日：2014-01-14

申请人： Xencor, Inc.

发明人： DESJARLAIS, John ,  MOORE, Gregory ,  RASHID, Rumana ,  BERNETT, Matthew J.

IPC分类号： C07K16/46

公开(公告)号：EP4149632A1

公开(公告)日：2023-03-22

申请号：EP21730426.0

申请日：2021-05-14

申请人： Xencor, Inc.

发明人： DESJARLAIS, John R. ,  BERNETT, Matthew J. ,  HEDVAT, Michael ,  GUSTI ZENG, Veronica ,  FABER, Matthew S.

IPC分类号： A61P35/00 ,  C07K16/28 ,  C07K16/30

公开(公告)号：EP3645122A1

公开(公告)日：2020-05-06

申请号：EP18752320.4

申请日：2018-07-02

申请人： Xencor, Inc.

发明人： BERNETT, Matthew J. ,  DESJARLAIS, John ,  VARMA, Rajat ,  SCHUBBERT, Suzanne ,  DIAZ, Juan

IPC分类号： A61P35/00 ,  C07K14/54 ,  C07K14/715 ,  C07K16/28

公开(公告)号：EP2059536B1

公开(公告)日：2014-01-08

申请号：EP07840953.9

申请日：2007-08-14

申请人： Xencor, Inc.

发明人： BERNETT, Matthew J. ,  CHU, Seung Yup ,  DESJARLAIS, John R. ,  KARKI, Sher Bahadur ,  LAZAR, Gregory Alan ,  PONG, Erik WeiKing ,  RICHARDS, John O. ,  ZHUKOVSKY, Eugene Alexander

IPC分类号： C07K16/28 ,  C12N15/13

CPC分类号： C07K16/2896 ,  C07K16/2803 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/72 ,  C07K2317/732 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2317/94

摘要： The present disclosure describes antibodies that target CD19, wherein the antibodies comprise at least one modification relative to a parent antibody, wherein the modification alters affinity to an Fcg³R or alters effector function as compared to the parent antibody. Also disclosed are methods of using said antibodies.